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$518 – $1202
In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.
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Repatha (evolocumab) is a human monoclonal antibody. It works by helping the liver reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) circulating in your blood.
Repatha is used together with a low-fat diet and other cholesterol-lowering medications in people with homozygous or heterozygous familial hypercholesterolemia (inherited types of high cholesterol). These conditions can cause high blood levels of LDL cholesterol, and can also cause plaque to build up inside your arteries.
Repatha is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis).
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
You should not use Repatha if you are allergic to evolocumab.
To make sure Repatha is safe for you, tell your doctor if you have ever had:
liver or kidney disease; or
a latex allergy.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of evolocumab on the baby.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
Do not give Repatha to a child without medical advice. Evolocumab is not approved for use by anyone younger than 13 years old. For certain conditions, Repatha should not be given to a child of any age.
Use Repatha exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Repatha is injected under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes.
Repatha is usually given once a month, or once every 2 weeks. Depending on your dose amount, you may need to use up to 3 separate injections at one time. Follow your doctor's dosing instructions very carefully.
Repatha is available in a prefilled syringe, a SureClick prefilled autoinjector, or a Pushtronex on-body infusor with prefilled cartridge. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions about your injection device, or call the manufacturer at 1-844-737-2842.
It may take up to 15 seconds to inject this medicine using a prefilled syringe or a SureClick autoinjector. If you use more than one injection at a time, be sure to finish all injections within 30 minutes.
The Pushtronex on-body infusor is a special hands-free device placed on the skin that delivers your evolocumab dose slowly. Read and carefully follow all instructions for using this product. You will need to wear the device for about 9 minutes to get the full dose. While wearing the on-body infusor, you may perform moderate activities such as walking, bending, or reaching.
Your care provider will show you the best places on your body to inject Repatha or place the on-body infusor. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
Each single-use prefilled syringe, cartridge, or injection device is for one use only. Throw away after one use, even if there is still some medicine left inside. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
Store Repatha in the refrigerator in its original carton and protect from light and heat. Do not freeze. Throw away any medicine that has been frozen.
Take the medicine out of the refrigerator and allow it to reach room temperature for 30 to 45 minutes before injecting your dose. Do not heat a syringe or injection device.
You may also store Repatha in the original carton at cool room temperature, away from light and heat. Use the medicine within 30 days if it is kept at room temperature.
Handle this medicine carefully. Dropping an injection device can cause it to break. Do not use an injection device that has been dropped onto a hard surface, even if you cannot see a break in it. Call your pharmacist for new medicine.
Do not shake this medicine. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.
You should not stop using Repatha without your doctor's advice, or your LDL cholesterol levels may increase.
Repatha is only part of a complete treatment program that also includes diet, statin medication, and regular blood testing. Follow your doctor's instructions very closely.
Usual Adult Dose of Repatha for Hyperlipidemia:
-140 mg subcutaneously every 2 weeks, or
-420 mg subcutaneously once a month
Comments:
-When switching dosage regimens, administer the first dose of the new regimen on the next scheduled date of prior regimen.
-This drug should not be used in patients without familial hypercholesterolemia or atherosclerotic cardio vascular disease.
Uses: Adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease requiring additional lowering of low density lipoprotein cholesterol (LDL-C)
Usual Adult Dose of Repatha for Homozygous Familial Hypercholesterolemia:
-420 mg subcutaneously once a month
Comments:
-Measure LDL-C levels every 4 to 8 weeks after starting this drug.
-Response to therapy depends on the degree of LDL-receptor function.
Uses: Adjunct to diet and other LDL-lowering therapies (e.g., statins, ezetimibe, LDL apheresis) for the treatment of patients with homozygous familial hypercholesterolemia (HoFH) requiring additional lowering of LDL-C
Use the missed dose within 7 days after that injection was due. Skip the missed dose if you are more than 7 days late for the injection. After a missed dose, go back to your original schedule and use the medicine again when your next scheduled dose is due.
Do not use extra medicine to make up a missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Do not inject Repatha into skin that is bruised, sore, scarred, or hardened.
Get emergency medical help if you have signs of an allergic reaction to Repatha: hives, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor.
Common Repatha side effects may include:
redness, pain, or bruising where an injection was given;
back pain;
flu symptoms; or
cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Other drugs may interact with evolocumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Repatha only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Repatha (www.drugs.com/repatha.html).
Note: This document contains side effect information about evolocumab. Some of the dosage forms listed on this page may not apply to the brand name Repatha.
Applies to evolocumab: subcutaneous solution
Along with its needed effects, evolocumab (the active ingredient contained in Repatha) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking evolocumab:
Incidence not known
Some side effects of evolocumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Applies to evolocumab: subcutaneous solution
The more commonly reported adverse reactions have included nasopharyngitis, upper respiratory tract infection, back pain, and injection site reactions.
Common (1% to 10%): Hypersensitivity reactions (including rash, eczema, erythema, urticaria)
Postmarketing reports: Angioedema
Common (1% to 10%): Hypertension
Common (1% to 10%): Diarrhea, gastroenteritis, nausea (1.8%)
Common (1% to 10%): Urinary tract infection
Common (1% to 10%): Injection site reaction (including erythema, pain, bruising)
Common (1% to 10%): Back pain, myalgia, musculoskeletal pain, arthralgia (1.8%)
Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Neurocognitive events (0.2%)
Common (1% to 10%): Influenza, fatigue (1.6%)
Uncommon (0.1% to 1%): Contusion
Common (1% to 10%): Influenza, fatigue (1.6%)
Uncommon (0.1% to 1%): Contusion
Rare (less than 0.1%): Development anti-drug antibody
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Repatha (www.drugs.com/repatha.html).
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