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Renvela Prescription
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Generic Name: sevelamer (se VEL a mer)
Brand Names: Renagel, Renvela
Renvela (sevelamer) reduces blood levels of phosphorus in people with chronic kidney disease who are on dialysis. Includes Renvela side effects, interactions and indications.
Generic Name: sevelamer (se VEL a mer)
Brand Names: Renagel, Renvela
Renvela (sevelamer) reduces blood levels of phosphorus in people with chronic kidney disease who are on dialysis. Includes Renvela side effects, interactions and indications.
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30 tablets of Renvela 40 mg
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Renvela Drug Information:

Renvela (sevelamer) is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus. Renvela is used to control phosphorus levels in people with chronic kidney disease who are on dialysis. Renvela may also be used for purposes not listed in this medication guide. You should not take Renvela if you have a bowel obstruction. Before taking Renvela, tell your doctor if you have severe constipation, a blockage in your intestines, a stomach or intestinal disorder, trouble swallowing, or if you have recently had stomach or intestinal surgery. Learn more

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Renvela Side Effects

Note: This document contains side effect information about sevelamer. Some of the dosage forms listed on this page may not apply to the brand name Renvela.

For the Consumer

Applies to sevelamer: oral powder for suspension, oral tablet

Along with its needed effects, sevelamer (the active ingredient contained in Renvela) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sevelamer:

Incidence not known

  • Bloody, black, or tarry stools
  • heartburn
  • indigestion
  • nausea
  • severe abdominal or stomach pain, cramping, or burning
  • severe constipation
  • severe vomiting
  • trouble with breathing
  • vomiting
  • vomiting of material that looks like coffee grounds, severe and continuing

Some side effects of sevelamer may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • bloating
  • constipation
  • diarrhea
  • excess air or gas in the stomach or intestines
  • full feeling
  • passing gas
  • stomach discomfort or upset

Incidence not known

  • Itching skin
  • rash

For Healthcare Professionals

Applies to sevelamer: oral capsule, oral powder for reconstitution, oral tablet


The most frequently occurring adverse reactions included nausea, vomiting, diarrhea, dyspepsia, abdominal pain, flatulence, and constipation.


Gastrointestinal events are the most common adverse reactions reported with this drug. Based on studies of 8 to 52 weeks, the most common reason for drug withdrawal are gastrointestinal adverse reactions (3% to 16%).

Very common (10% or more): Vomiting (22%), nausea (20%), diarrhea (19%), dyspepsia (16%)

Common (1% to 10%): Abdominal pain, flatulence, constipation, gastrointestinal reflux disease

Frequency not reported: Dysphagia, diverticulitis

Postmarketing reports: Fecal impaction, ileus, intestinal obstruction, intestinal perforation


Common (1% to 10%): Peritonitis

A clinical study in patients receiving peritoneal dialysis (n=143) found the most frequently occurring treatment emergent serious adverse reaction was peritonitis. Peritonitis occurred in 8 patients receiving sevelamer and 2 patients on active control.


Common (1% to 10%): Anorexia

Uncommon (0.1% to 1%): Acidosis, increased serum chloride levels, decreased carbon dioxide


Postmarketing reports: Hypersensitivity


Very common (10% or more): Nasopharyngitis, bronchitis

Common (1% to 10%): Cough, upper respiratory tract infection, dyspnea


Postmarketing reports: Pruritus, rash


Common (1% to 10%): Urinary tract infection


Common (1% to 10%): Hypertension


Common (1% to 10%): Arteriovenous fistula site complication, arteriovenous fistula site hemorrhage, arteriovenous fistula thrombosis

Nervous system

Common (1% to 10%): Dizziness, headache


Common (1% to 10%): Fatigue, fever


Common (1% to 10%): Arthralgia, muscle spasms, extremity pain

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Renvela (www.drugs.com/renvela.html).