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Generic Name: becaplermin topical (be KAP ler min TOP ik al)
Brand Name: Regranex
Physician reviewed Regranex patient information - includes Regranex description, dosage and directions.
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Drug Information:
Regranex (for the skin) is used to treat diabetic foot ulcers in people with normal blood flow in the legs and feet. Regranex is not for use in treating pressure ulcers (bed sores) or ulcers caused by poor circulation. Regranex may also be used for purposes not listed in this medication guide. You should not use Regranex if you have cancer affecting the skin where you will apply this medicine. Some people using becaplermin have developed cancer. However, it is not known whether this medicine actually causes cancer. Learn more

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Regranex Side Effects

Note: This document contains side effect information about becaplermin topical. Some of the dosage forms listed on this page may not apply to the brand name Regranex.

For the Consumer

Applies to becaplermin topical: topical gel/jelly


Topical application route (Gel/Jelly)

An increased rate of mortality secondary to malignancy was observed in patients treated with 3 or more tubes of becaplermin gel in a postmarketing retrospective cohort study. Becaplermin gel should only be used when the benefits can be expected to outweigh the risks and should be used with caution in patients with known malignancy.

Along with its needed effects, becaplermin topical (the active ingredient contained in Regranex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking becaplermin topical:

Less common

  • Reddened skin near the skin ulcer
  • skin rash near the skin ulcer

Incidence not known

  • Burning sensation at the application site
  • unusually warm skin

For Healthcare Professionals

Applies to becaplermin topical: topical gel


Eight of 291 patients (2.7%) on this drug versus 2 of 200 placebo patients (1%) in 20 month clinical trial follow up studies developed cancer; types of cancer varied and all were remote from the treatment site.

Three retrospective postmarketing studies showed an increased death rate from systemic malignancies in patients who had used 3 or more tubes of becaplermin.

Common (1% to 10%): Cancer

Postmarketing reports: Increased death rate from systemic malignancies


Common (1% to 10%): Erythematous rash


Postmarketing reports: Burning sensation at application site, erythema at application site

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Regranex (www.drugs.com/mtm/regranex.html).