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Ranexa

Generic Name: ranolazine (ra NOE la zeen)
Brand Names: Ranexa
Ranexa (ranolazine) is used to chronic treat angina (chest pain). Learn about side effects, interactions and indications.
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Drug Information:
Ranexa (ranolazine) is used to treat chronic angina (chest pain). It works by improving blood flow to help the heart work more efficiently. Ranexa is not for use during an acute (emergency) attack of angina. Ranexa may also be used for purposes not listed in this medication guide. You should not take Ranexa if you have cirrhosis of the liver. Serious drug interactions can occur when certain medicines are used together with ranolazine. Tell each of your healthcare prOviders about all medicines you use now, and any medicine you start or stop using. Learn more

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Ranexa Side Effects

Note: This document contains side effect information about ranolazine. Some of the dosage forms listed on this page may not apply to the brand name Ranexa.

In Summary

More frequent side effects include: constipation, dizziness, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ranolazine: oral tablet extended release

Along with its needed effects, ranolazine (the active ingredient contained in Ranexa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ranolazine:

More common

  • Dizziness

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • continuous ringing or buzzing or other unexplained noise in the ears
  • difficult or labored breathing
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of constant movement of self or surroundings
  • hearing loss
  • lightheadedness
  • rapid weight gain
  • sensation of spinning
  • tightness in the chest
  • tingling of the hands or feet
  • unusual weight gain or loss

Rare

  • Abnormal or decreased touch sensation
  • agitation
  • blood in the urine
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chills
  • cold sweats
  • coma
  • confusion
  • decreased urine output
  • depression
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • headache
  • hostility
  • irritability
  • lethargy
  • muscle twitching
  • nausea
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • slow or irregular heartbeat
  • stupor
  • sweating
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness

Some side effects of ranolazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement (stool)

Less common

  • Dry mouth
  • stomach pain

Rare

  • Lack or loss of strength

For Healthcare Professionals

Applies to ranolazine: oral tablet extended release

General

The most common adverse reactions were dizziness, headache, constipation, and nausea.

Gastrointestinal

Common (1% to 10%): Constipation, nausea, vomiting

Uncommon (0.1% to 1%): Abdominal pain, dry mouth, dyspepsia, flatulence, stomach discomfort

Rare (less than 0.1%): Pancreatitis, erosive duodenitis, oral hypoesthesia

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Lethargy, syncope, hypoesthesia, somnolence, tremor, postural dizziness, paresthesia, vertigo, tinnitus

Rare (less than 0.1%): Amnesia, depressed level of consciousness, loss of consciousness, coordination abnormal, gait disturbance, parosmia

Postmarketing reports: Myoclonus

Other

Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Fatigue, peripheral edema

Rare (less than 0.1%): Impaired hearing

Metabolic

Uncommon (0.1% to 1%): Anorexia, appetite decreased, dehydration, weight decreased

Rare (less than 0.1%): Hyponatremia

Postmarketing reports: Hypoglycemia

Psychiatric

Uncommon (0.1% to 1%): Anxiety, insomnia, confusional state, hallucination

Rare (less than 0.1%): Disorientation

Musculoskeletal

Uncommon (0.1% to 1%): Pain in extremity, muscle cramp, joint swelling, muscular weakness

Cardiovascular

Uncommon (0.1% to 1%): Hot flush, hypotension, prolonged QT corrected interval

Rare (less than 0.1%): Peripheral coldness, orthostatic hypotension

Frequency not reported: Bradycardia, palpitations

Genitourinary

Uncommon (0.1% to 1%): Dysuria, hematuria, chromaturia

Rare (less than 0.1%): Urinary retention, erectile dysfunction

Respiratory

Uncommon (0.1% to 1%): Dyspnea, cough, epistaxis

Rare (less than 0.1%): Throat tightness

Frequency not reported: Pulmonary fibrosis

Ocular

Uncommon (0.1% to 1%): Blurred vision, visual disturbance, diplopia

Renal

Uncommon (0.1% to 1%): Serum creatinine increased, blood urea increased

Rare (less than 0.1%): Acute renal failure

Frequency not reported: Blood urea increased

Dermatologic

Uncommon (0.1% to 1%): Pruritus, hyperhidrosis

Rare (less than 0.1%): Angioedema, urticaria, cold sweat, rash

Hematologic

Uncommon (0.1% to 1%): Platelet or white blood cell count increased

Frequency not reported: Eosinophilia, thrombocytopenia, leukopenia, pancytopenia

Hepatic

Rare (less than 0.1%): Hepatic enzyme levels elevated

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Ranexa (www.drugs.com/ranexa.html).