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Raloxifene Hydrochloride

Raloxifene hydrochloride Prescription
Generic Name: raloxifene (ra LOX i feen)
Brand Name: Evista
Physician reviewed raloxifene patient information - includes raloxifene description, dosage and directions.
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Raloxifene Hydrochloride Drug Information:

RAloxifene is used to treat osteoporosis in postmenopausal women. RAloxifene is not for use in men. RAloxifene may also be used for purposes not listed in this medication guide. rAloxifene may increase your risk of a blood clot in your leg, your lung, or your eye. You should not take rAloxifene if you have ever had this type of blood clot. RAloxifene can also increase your risk of a stroke, which can be fatal. This risk is highest if you have certain risk factors (such as smoking, having heart problems or high blood pressure, or if you have ever had a heart attack or a stroke). Learn more

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Raloxifene Hydrochloride Side Effects

In Summary

Commonly reported side effects of raloxifene include: infection, flu-like symptoms, hot flash, and sinusitis. Other side effects include: lower limb cramp. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to raloxifene: oral tablet

Warning

Oral route (Tablet)

Increased risk of deep vein thrombosis and pulmonary embolism have been reported. Women with active or past history of venous thromboembolism should not take raloxifene hydrochloride. Increased risk of death due to stroke occurred in a trial in postmenopausal women with documented coronary heart disease or at increased risk for major coronary events. Consider risk-benefit balance in women at risk for stroke.

Side effects requiring immediate medical attention

Along with its needed effects, raloxifene may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking raloxifene and get emergency help immediately if any of the following effects occur:

Rare

  • Coughing blood
  • headache or migraine headache
  • loss of or change in speech, coordination, or vision
  • pain or numbness in chest, arm, or leg
  • shortness of breath (unexplained)

Check with your doctor as soon as possible if any of the following side effects occur while taking raloxifene:

More common

  • Bloody or cloudy urine
  • chest pain
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • infection, including body aches or pain, congestion in throat, cough, dryness or soreness of throat, runny nose, and loss of voice
  • leg cramping
  • skin rash
  • swelling of hands, ankles, or feet
  • vaginal itching

Less common

  • Abdominal pain (severe)
  • aching body pains
  • congestion in lungs
  • decreased vision or other changes in vision
  • diarrhea
  • difficulty in breathing
  • hoarseness
  • loss of appetite
  • nausea
  • trouble in swallowing
  • weakness
Side effects not requiring immediate medical attention

Some side effects of raloxifene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Hot flashes, including sudden sweating and feelings of warmth (especially common during the first 6 months of treatment)
  • increased white vaginal discharge
  • joint or muscle pain
  • mental depression
  • problems of stomach or intestines, including passing of gas, upset stomach, or vomiting
  • swollen joints
  • trouble in sleeping
  • weight gain (unexplained)

For Healthcare Professionals

Applies to raloxifene: oral tablet

Cardiovascular

Very common (10% or more): Hot flashes/hot flushes/vasodilation (28.7%), increased blood pressure

Common (1% to 10%): Varicose vein, venous thromboembolism (VTE)

Postmarketing reports: Death related to VTE

Other

Very common (10% or more): Flu syndrome (16.2%), infection (15.1%), peripheral edema (14.1%)

Common (1% to 10%): Chest pain, fever

Musculoskeletal

Very common (10% or more): Arthralgia (15.5%), muscle spasms/leg cramps (12.1%)

Common (1% to 10%): Myalgia, arthritis, tendon disorder

Respiratory

Very common (10% or more): Sinusitis (10.3%), rhinitis (10.2%)

Common (1% to 10%): Bronchitis, pharyngitis, increased cough, pneumonia, laryngitis

Dermatologic

Common (1% to 10%): Rash, sweating

Endocrine

Common (1% to 10%): Breast pain/tenderness/enlargement

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, dyspepsia, vomiting, flatulence, gastrointestinal disorder, gastroenteritis, abdominal pain

Genitourinary

Common (1% to 10%): Vaginitis, urinary tract infection, cystitis, leukorrhea, uterine disorder, vaginal bleeding, endometrial disorder, vaginal hemorrhage, urinary tract disorder

Hepatic

Common (1% to 10%): Cholelithiasis, cholecystectomy

Frequency not reported: Slightly decreased platelet counts, moderate increases in AST and/or ALT

Metabolic

Common (1% to 10%): Weight gain

Nervous system

Common (1% to 10%): Headache/migraine, syncope, vertigo, neuralgia, hypesthesia, stroke, death related to stroke

Ocular

Common (1% to 10%): Conjunctivitis

Postmarketing reports: Retinal vein occlusion

Psychiatric

Common (1% to 10%): Depression, insomnia

Hematologic

Uncommon (0.1% to 1%): Thrombocytopenia

Oncologic

Uncommon (0.1% to 1%): Benign endometrial polyps

Frequency not reported: Endometrial cancer, ovarian cancer, endometrial atrophy

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Raloxifene Hydrochloride (www.drugs.com/mtm/raloxifene.html).