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Commonly reported side effects of rabeprazole include: atrophic gastritis. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to rabeprazole: oral capsule delayed release, oral tablet enteric coated
Along with its needed effects, rabeprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking rabeprazole:
Less common
Rare
Incidence not known
Some side effects of rabeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to rabeprazole: oral delayed release capsule, oral delayed release tablet, oral tablet extended release
GeneralThe most commonly reported side effects are headache, diarrhea, and abdominal pain.
GastrointestinalVery common (10% or more): Diarrhea (up to 21%), abdominal pain (up to 16%), vomiting (up to 14%)
Common (1% to 10%): Benign fundic gland polyps, constipation, flatulence, nausea
Uncommon (0.1% to 1%): Dry mouth, dyspepsia, eructation
Rare (0.01% to 0.1%): Gastritis, stomatitis
Frequency not reported: Microscopic colitis
Postmarketing reports: Clostridium difficile-associated diarrhea
OtherCommon (1% to 10%): Asthenia, non-specific pain, pain
Uncommon (0.1% to 1%): Chills, pyrexia/fever
Postmarketing reports: Sudden death
RespiratoryCommon (1% to 10%): Cough, pharyngitis, rhinitis
Uncommon (0.1% to 1%): Bronchitis, sinusitis
Postmarketing reports: Dyspnea, interstitial pneumonia
Nervous systemCommon (1% to 10%): Dizziness, headache, taste disturbance/perversion
Uncommon (0.1% to 1%): Somnolence
Rare (0.01% to 0.1%): Hepatic encephalopathy
Postmarketing reports: Coma, vertigo
Hepatic encephalopathy occurred in patients with underlying cirrhosis.
ImmunologicCommon (1% to 10%): Flu-like syndrome/ influenza-like illness, infection
MusculoskeletalCommon (1% to 10%): Back pain, myalgia
Uncommon (0.1% to 1%): Arthralgia, fracture of hip/wrist/spine, leg cramps
Postmarketing reports: Bone fractures, rhabdomyolysis
DermatologicCommon (1% to 10%): Rash
Uncommon (0.1% to 1%): Erythema
Rare (0.01% to 0.1%): Bullous reactions, pruritus, sweating
Very rare (less than 0.01%): Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)
Frequency not reported: Facial swelling, subacute cutaneous lupus erythematosus
Postmarketing reports: fatal TEN, other drug eruptions, severe dermatological reactions, systemic lupus erythematosus, urticarial skin eruptions
Erythema and bullous reactions usually resolved after discontinuation.
PsychiatricCommon (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Nervousness
Rare (0.01% to 0.1%): Depression
Frequency not reported: Confusion
Postmarketing reports: Delirium, disorientation
CardiovascularCommon (1% to 10%): Chest pain
Uncommon (0.1% to 1%): Peripheral edema
Postmarketing reports: Hypotension
HepaticUncommon (0.1% to 1%): Increased hepatic enzymes
Rare (0.01% to 0.1%): Hepatitis, jaundice, serious hepatic dysfunction
Increased hepatic enzymes occurred in patients with underlying cirrhosis.
GenitourinaryUncommon (0.1% to 1%): Urinary tract infection
HematologicRare (0.01% to 0.1%): Leukocytosis, leukopenia, neutropenia, thrombocytopenia
Postmarketing reports: Agranulocytosis, bicytopenia, blood dyscrasias, hemolytic anemia, increase in prothrombin time/INR, pancytopenia
Increased prothrombin time/INR occurred in patients taking warfarin concomitantly.
MetabolicRare (0.01% to 0.1%): Anorexia, weight gain
Frequency not reported: Cyanocobalamin (Vitamin B-12) deficiency, hypomagnesemia, hyponatremia
Postmarketing reports: Hyperammonemia
RenalRare (0.01% to 0.1%): Interstitial nephritis
OcularRare (0.01% to 0.1%): Visual disturbance
Postmarketing reports: Blurred vision
EndocrineFrequency not reported: Gynecomastia
Postmarketing reports: Thyroid stimulating hormone (TSH) elevations
HypersensitivityHypersensitivity reactions included facial swelling, hypotension, dyspnea, erythema, and bullous reactions; these reactions typically resolved after discontinuation.
Rare (0.01% to 0.1%): Hypersensitivity
Postmarketing reports: Acute systemic allergic reactions, anaphylaxis/anaphylactic reactions, angioedema, potential allergic reactions
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Rabeprazole Sodium (www.drugs.com/rabeprazole.html).
August 31, 2020
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