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Rabeprazole Sodium

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Rabeprazole sodium Prescription
Rabeprazole Sodium reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).
Average Savings for rabeprazole sodium (generic): 54.86%
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Rabeprazole Sodium Drug Information:

Acid- or proton-pump inhibitor; gastric antisecretory agent. Short-term treatment of symptomatic GERD (e.g., heartburn) in patients without erosive esophagitis. Short-term treatment of erosive esophagitis in patients with GERD. Maintain healing and decrease recurrence of erosive esophagitis. Short-term treatment of active duodenal ulcer. Treatment of Helicobacter pylori infection and duodenal ulcer disease. Used in conjunction with Amoxicillin and Clarithromycin (triple therapy). Long-term treatment of pathologic GI hypersecretory conditions (e.g., Zollinger-Ellison syndrome). Learn more

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Rabeprazole Sodium Side Effects

In Summary

Commonly reported side effects of rabeprazole include: atrophic gastritis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rabeprazole: oral capsule delayed release, oral tablet enteric coated

Along with its needed effects, rabeprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rabeprazole:

Less common


Incidence not known

Some side effects of rabeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to rabeprazole: oral delayed release capsule, oral delayed release tablet, oral tablet extended release


The most commonly reported side effects are headache, diarrhea, and abdominal pain.


Very common (10% or more): Diarrhea (up to 21%), abdominal pain (up to 16%), vomiting (up to 14%)

Common (1% to 10%): Benign fundic gland polyps, constipation, flatulence, nausea

Uncommon (0.1% to 1%): Dry mouth, dyspepsia, eructation

Rare (0.01% to 0.1%): Gastritis, stomatitis

Frequency not reported: Microscopic colitis

Postmarketing reports: Clostridium difficile-associated diarrhea


Common (1% to 10%): Asthenia, non-specific pain, pain

Uncommon (0.1% to 1%): Chills, pyrexia/fever

Postmarketing reports: Sudden death


Common (1% to 10%): Cough, pharyngitis, rhinitis

Uncommon (0.1% to 1%): Bronchitis, sinusitis

Postmarketing reports: Dyspnea, interstitial pneumonia

Nervous system

Common (1% to 10%): Dizziness, headache, taste disturbance/perversion

Uncommon (0.1% to 1%): Somnolence

Rare (0.01% to 0.1%): Hepatic encephalopathy

Postmarketing reports: Coma, vertigo

Hepatic encephalopathy occurred in patients with underlying cirrhosis.


Common (1% to 10%): Flu-like syndrome/ influenza-like illness, infection


Common (1% to 10%): Back pain, myalgia

Uncommon (0.1% to 1%): Arthralgia, fracture of hip/wrist/spine, leg cramps

Postmarketing reports: Bone fractures, rhabdomyolysis


Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Erythema

Rare (0.01% to 0.1%): Bullous reactions, pruritus, sweating

Very rare (less than 0.01%): Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)

Frequency not reported: Facial swelling, subacute cutaneous lupus erythematosus

Postmarketing reports: fatal TEN, other drug eruptions, severe dermatological reactions, systemic lupus erythematosus, urticarial skin eruptions

Erythema and bullous reactions usually resolved after discontinuation.


Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Nervousness

Rare (0.01% to 0.1%): Depression

Frequency not reported: Confusion

Postmarketing reports: Delirium, disorientation


Common (1% to 10%): Chest pain

Uncommon (0.1% to 1%): Peripheral edema

Postmarketing reports: Hypotension


Uncommon (0.1% to 1%): Increased hepatic enzymes

Rare (0.01% to 0.1%): Hepatitis, jaundice, serious hepatic dysfunction

Increased hepatic enzymes occurred in patients with underlying cirrhosis.


Uncommon (0.1% to 1%): Urinary tract infection


Rare (0.01% to 0.1%): Leukocytosis, leukopenia, neutropenia, thrombocytopenia

Postmarketing reports: Agranulocytosis, bicytopenia, blood dyscrasias, hemolytic anemia, increase in prothrombin time/INR, pancytopenia

Increased prothrombin time/INR occurred in patients taking warfarin concomitantly.


Rare (0.01% to 0.1%): Anorexia, weight gain

Frequency not reported: Cyanocobalamin (Vitamin B-12) deficiency, hypomagnesemia, hyponatremia

Postmarketing reports: Hyperammonemia


Rare (0.01% to 0.1%): Interstitial nephritis


Rare (0.01% to 0.1%): Visual disturbance

Postmarketing reports: Blurred vision


Frequency not reported: Gynecomastia

Postmarketing reports: Thyroid stimulating hormone (TSH) elevations


Hypersensitivity reactions included facial swelling, hypotension, dyspnea, erythema, and bullous reactions; these reactions typically resolved after discontinuation.

Rare (0.01% to 0.1%): Hypersensitivity

Postmarketing reports: Acute systemic allergic reactions, anaphylaxis/anaphylactic reactions, angioedema, potential allergic reactions

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Rabeprazole Sodium (www.drugs.com/rabeprazole.html).

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