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Qsymia Prescription
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Generic Name: phentermine and topiramate (FEN ter meen and toe PIR a mate)
Brand Names: Qsymia
Qsymia (phentermine and topiramate) is used together with diet and exercise to treat obesity. Qsymia information includes news, clinical trial results and side effects.
Generic Name: phentermine and topiramate (FEN ter meen and toe PIR a mate)
Brand Names: Qsymia
Qsymia (phentermine and topiramate) is used together with diet and exercise to treat obesity. Qsymia information includes news, clinical trial results and side effects.
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30 tablets of Qsymia 40 mg
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Qsymia Drug Information:

Qsymia contains a combination of phentermine and Topiramate in an extended-release capsule. Phentermine is an appetite suppressant similar to an amphetamine. Topiramate is typically used as a seizure medication, also called an anticonvulsant. Qsymia is used together with diet and exercise to treat obesity. This medicine is sometimes used to treat obesity that may be related to Diabetes, high cholesterol, or high blood pressure. Qsymia will not treat any these underlying conditions. Keep using any other medicines your doctor has prescribed to treat these conditions. Learn more

Qsymia Medicare Coverage

Qsymia Medicare Overview

Does Medicare cover Qsymia?


In general, Medicare plans do not cover this drug. This drug will likely be quite expensive and you may want to consider using a USARx discount instead of Medicare to find the best price for this prescription.
How much is my Qsymia co-pay with Medicare?

It depends. Which coverage stage are you in? Click on a tab below…



In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.

Ways to Save on Qsymia

Here are some ways that may lower the cost of your qsymia prescription.

  • Instead of Medicare, Use a USA Rx Coupon

    If your Medicare co-pay is higher, you can save money by using a USARx coupon instead.

Qsymia Side Effects

Note: This document contains side effect information about phentermine / topiramate. Some of the dosage forms listed on this page may not apply to the brand name Qsymia.

In Summary

Common side effects of Qsymia include: constipation, insomnia, nasopharyngitis, paresthesia, mood disorder, sleep disorder, and xerostomia. Other side effects include: urinary tract infection, anxiety, blurred vision, depression, dizziness, fatigue, influenza, nausea, increased serum creatinine, and dysgeusia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to phentermine / topiramate: oral capsule extended release

Along with its needed effects, phentermine/topiramate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking phentermine / topiramate:

Less common

  • Chest discomfort
  • convulsions
  • decreased urine
  • fast, irregular, pounding, or racing heartbeat or pulse
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • unusual tiredness or weakness


  • Blood in the urine
  • pain in the groin or genitals
  • sharp back pain just below the ribs

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • blisters on the mouth, trunk, scalp, or other areas
  • blurred or decreased vision
  • chest pain
  • chills or shivering
  • clumsiness
  • continuing nausea or vomiting
  • cough or sore throat
  • dark urine
  • diarrhea or light-colored stools
  • dizziness
  • headache
  • increase in the frequency of seizures
  • irregular heartbeat
  • itching
  • joint or muscle pain
  • loss of appetite
  • low body temperature
  • muscle aches or weakness
  • pain in the shoulders, arms, jaw, or neck
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • shakiness in the legs, arms, hands, or feet
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling of the face
  • tiredness and weakness
  • trouble thinking, speaking, or walking
  • upper right abdominal or stomach pain
  • weak or feeble pulse
  • weight gain
  • yellow eyes or skin

Some side effects of phentermine / topiramate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • change in taste
  • difficulty having a bowel movement (stool)
  • ear congestion
  • fear or nervousness
  • loss of taste
  • loss of voice
  • memory problems
  • pain or tenderness around the eyes and cheekbones
  • sneezing
  • stuffy or runny nose
  • trouble sleeping

Less common

  • Belching
  • cramps
  • decreased appetite
  • dry eyes
  • eye pain
  • hair loss
  • heartburn or indigestion
  • heavy bleeding
  • irritability
  • rash
  • stomach discomfort, upset, or pain

Incidence not known

  • Bloating
  • false or unusual sense of well-being
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • feeling, seeing, or hearing things that are not there
  • hives or welts
  • change in sexual ability, desire, drive, or performance
  • severe mood or mental changes
  • unusual behavior

For Healthcare Professionals

Applies to phentermine / topiramate: oral capsule extended release

Nervous system

Very common (10% or more): Paraesthesia (up to 19.9%), headache (up to 10.6%)

Common (1% to 10%): Dysgeusia, dizziness, hypoesthesia, disturbance in attention, cognitive impairment


Postmarketing reports: Euphoria, psychosis, tremor


Common (1% to 10%): Insomnia, anxiety, depression/mood problems, irritability

Postmarketing reports: Suicidal ideation, suicidal behavior


Postmarketing reports: Libido changes, impotence


Very common (10% or more): Decreased serum bicarbonate (up to 12.8%)

Common (1% to 10%): Hypokalemia, decreased serum potassium, decreased appetite


Postmarketing reports: Hyperammonemia


Common (1% to 10%): Elevated serum creatinine, nephrolithiasis


Very common (10% or more): Elevated resting heart rate (up to 77.7%)

Common (1% to 10%): Palpitations


Postmarketing reports: Elevated blood pressure, ischemic events


Common (1% to 10%): Blurred vision, dry eye, eye pain

Postmarketing reports: Acute angle closure glaucoma, increased intraocular pressure


Postmarketing reports: Maculopathy


Common (1% to 10%): Fatigue, thirst, chest discomfort, procedural pain


Postmarketing reports: Hypothermia


Common adverse reactions occurring at a rate of 5% or more and at a rate of at least 1.5 times placebo include paraesthesia, dizziness, dysgeusia, insomnia, constipation, and dry mouth.


Common (1% to 10%): Alopecia, rash


Postmarketing reports: Bullous skin reactions (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), pemphigus


Very common (10% or more): Dry mouth (up to 19.1%), constipation (up to 16.1%)

Common (1% to 10%): Nausea, diarrhea, gastroesophageal reflux disease, dyspepsia, oral paraesthesia, gastroenteritis


Postmarketing reports: Pancreatitis


Common (1% to 10%): Dysmenorrhea, urinary tract infection



Postmarketing reports: Hepatic failure (including fatalities), hepatitis



Postmarketing reports: Urticaria


Common (1% to 10%): Influenza


Common (1% to 10%): Back pain, extremity pain, muscle spasms, musculoskeletal pain, neck pain


Very common (10% or more): Upper respiratory tract infection (up to 15.8%), nasopharyngitis (up to 12.5%)

Common (1% to 10%): Sinusitis, bronchitis, cough, sinus congestion, pharyngolaryngeal pain, nasal congestion

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Qsymia (www.drugs.com/qsymia.html).