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Note: This document contains side effect information about phentermine / topiramate. Some of the dosage forms listed on this page may not apply to the brand name Qsymia.
In SummaryCommon side effects of Qsymia include: constipation, insomnia, nasopharyngitis, paresthesia, mood disorder, sleep disorder, and xerostomia. Other side effects include: urinary tract infection, anxiety, blurred vision, depression, dizziness, fatigue, influenza, nausea, increased serum creatinine, and dysgeusia. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to phentermine / topiramate: oral capsule extended release
Along with its needed effects, phentermine/topiramate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking phentermine / topiramate:
Less common
Rare
Incidence not known
Some side effects of phentermine / topiramate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Incidence not known
For Healthcare Professionals
Applies to phentermine / topiramate: oral capsule extended release
Nervous systemVery common (10% or more): Paraesthesia (up to 19.9%), headache (up to 10.6%)
Common (1% to 10%): Dysgeusia, dizziness, hypoesthesia, disturbance in attention, cognitive impairment
Phentermine:
Postmarketing reports: Euphoria, psychosis, tremor
PsychiatricCommon (1% to 10%): Insomnia, anxiety, depression/mood problems, irritability
Postmarketing reports: Suicidal ideation, suicidal behavior
Phentermine:
Postmarketing reports: Libido changes, impotence
MetabolicVery common (10% or more): Decreased serum bicarbonate (up to 12.8%)
Common (1% to 10%): Hypokalemia, decreased serum potassium, decreased appetite
Topiramate:
Postmarketing reports: Hyperammonemia
RenalCommon (1% to 10%): Elevated serum creatinine, nephrolithiasis
CardiovascularVery common (10% or more): Elevated resting heart rate (up to 77.7%)
Common (1% to 10%): Palpitations
Phentermine:
Postmarketing reports: Elevated blood pressure, ischemic events
OcularCommon (1% to 10%): Blurred vision, dry eye, eye pain
Postmarketing reports: Acute angle closure glaucoma, increased intraocular pressure
Topiramate:
Postmarketing reports: Maculopathy
OtherCommon (1% to 10%): Fatigue, thirst, chest discomfort, procedural pain
Topiramate:
Postmarketing reports: Hypothermia
GeneralCommon adverse reactions occurring at a rate of 5% or more and at a rate of at least 1.5 times placebo include paraesthesia, dizziness, dysgeusia, insomnia, constipation, and dry mouth.
DermatologicCommon (1% to 10%): Alopecia, rash
Topiramate:
Postmarketing reports: Bullous skin reactions (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), pemphigus
GastrointestinalVery common (10% or more): Dry mouth (up to 19.1%), constipation (up to 16.1%)
Common (1% to 10%): Nausea, diarrhea, gastroesophageal reflux disease, dyspepsia, oral paraesthesia, gastroenteritis
Topiramate:
Postmarketing reports: Pancreatitis
GenitourinaryCommon (1% to 10%): Dysmenorrhea, urinary tract infection
HepaticTopiramate:
Postmarketing reports: Hepatic failure (including fatalities), hepatitis
HypersensitivityPhentermine:
Postmarketing reports: Urticaria
ImmunologicCommon (1% to 10%): Influenza
MusculoskeletalCommon (1% to 10%): Back pain, extremity pain, muscle spasms, musculoskeletal pain, neck pain
RespiratoryVery common (10% or more): Upper respiratory tract infection (up to 15.8%), nasopharyngitis (up to 12.5%)
Common (1% to 10%): Sinusitis, bronchitis, cough, sinus congestion, pharyngolaryngeal pain, nasal congestion
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Qsymia (www.drugs.com/qsymia.html).
September 30, 2020
September 30, 2020
March 3, 2021
June 23, 2016
May 17, 2022
May 17, 2022