Please wait...
Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:
USARx offers multiple ways to purchase this medication. Choose the Best option for you!
Propylthiouracil is used to treat hyperthyroidism (overactive thyroid), Graves' disease, or toxic goiter (enlarged thyroid). propylthiouracil is sometimes given to control symptoms just before you undergo thyroid surgery or treatment with radioactive iodine.
Propylthiouracil is for use only if your condition cannot be treated with another thyroid medication, or when surgery or radioactive iodine are not good treatment options.
Propylthiouracil may also be used for purposes not listed in this medication guide.
Propylthiouracil can cause liver problems that can be fatal or may require a liver transplant. Stop taking this medicine and call your doctor right away if you have signs of liver damage: fever, itching, tiredness, nausea, vomiting, upper stomach pain, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
Do not use propylthiouracil if you are pregnant.
You should not use propylthiouracil if you are allergic to it.
Tell your doctor if you have ever had liver problems.
Do not use propylthiouracil if you are pregnant, and tell your doctor right away if you become pregnant. Propylthiouracil can harm an unborn baby, or cause serious liver problems or death of the baby or the mother. You may need to use another medication during late pregnancy.
It may not be safe to breast-feed while using propylthiouracil. Ask your doctor about any risk.
In most cases, propylthiouracil should not be used by anyone younger than 18 years old. Do not give propylthiouracil to a child without your doctor's advice.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Propylthiouracil is usually taken 3 times per day.
You will need frequent blood tests to check your thyroid function.
Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, sore throat).
If you need surgery, tell your surgeon you currently use propylthiouracil.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Get your prescription refilled before you run out of medicine completely.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include fever, chills, itching, upset stomach, nausea, vomiting, swelling, headache, or joint pain.
Avoid driving or hazardous activity until you know how propylthiouracil will affect you. Your reactions could be impaired.
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Propylthiouracil can cause liver damage (especially during the first 6 months of treatment). Liver failure can be fatal or may require a liver transplant. Stop taking propylthiouracil and call your doctor right away if you have signs of liver damage:
nausea, vomiting, upper stomach pain;
itching;
fever, tiredness;
loss of appetite;
dark urine, clay-colored stools; or
jaundice (yellowing of the skin or eyes).
Also call your doctor at once if you have:
fever, chills, sore throat, mouth sores, feeling light-headed;
unusual bleeding;
purple or red discoloration of your skin;
skin rash, skin pain or swelling;
pink or dark urine, foamy urine, little or no urination;
shortness of breath, or if you cough up blood; or
new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.
Common side effects may include:
nausea, vomiting, stomach pain;
itching or tingling;
joint or muscle pain;
swollen glands;
headache, drowsiness, dizziness;
swelling in your hands or feet;
decreased sense of taste; or
hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all your other medicines, especially:
digoxin (digitalis);
theophylline;
heart or blood pressure medication; or
a blood thinner--warfarin, Coumadin, Jantoven.
This list is not complete. Other drugs may affect propylthiouracil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Propylthiouracil (www.drugs.com/mtm/propylthiouracil.html).
Applies to propylthiouracil: oral tablet
Oral route (Tablet)
Severe liver injury and acute liver failure, including fatalities, have been reported with propylthiouracil. Liver transplantation was required in some cases. Reserve propylthiouracil for patients who can not tolerate methimazole when radioactive iodine therapy or surgery are not appropriate treatment options. Propylthiouracil may be the preferred treatment when an antithyroid drug is indicated during or just prior to the first trimester of pregnancy, because of the risk of fetal abnormalities associated with methimazole.
Along with its needed effects, propylthiouracil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking propylthiouracil:
More common
Less common
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking propylthiouracil:
Symptoms of overdose
Some side effects of propylthiouracil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to propylthiouracil: oral tablet
The more commonly reported adverse events have included nausea, taste perversion, and itching.
Liver injury resulting in liver failure presenting as hepatitis, liver failure necessitating liver transplantation or resulting in death, has been reported. Cases of liver injury and death were reported in women during pregnancy; two reports of liver failure and death have been received in newborns exposed to this drug in utero.
Common (1% to 10%): Asymptomatic liver function test abnormalities (increased serum bilirubin, alanine transaminase and/or alkaline phosphatase concentrations), which are reversible on dose reduction or discontinuation of treatment
Frequency not reported: Liver injury presenting as hepatitis, liver failure necessitating liver transplantation jaundice (usually cholestatic), hepatic necrosis, hepatic failure
Vasculitis resulting in severe complications and death have been reported. These cases have included glomerulonephritis, leukocytoclastic cutaneous vasculitis, alveolar/pulmonary hemorrhage, cerebral angiitis, and ischemic colitis. Most were associated with anti-neutrophilic cytoplasmic antibodies (ANCA)-positive vasculitis.
Frequency not reported: Vasculitis syndrome, lupus-like syndrome (including splenomegaly and vasculitis), sialadenopathy
Rare (Less than 0.1%): Agranulocytosis, thrombocytopenia, leucopenia, aplastic anemia, pancytopenia, hemorrhage, granulocytopenia
Frequency not reported: Hypoprothrombinemia, lymphadenopathy
Rare (0.01% to 0.1%): Stevens Johnson syndrome, toxic epidermal necrolysis
Very rare (less than 0.01%): Skin rash, urticaria
Frequency not reported: Exfoliative dermatitis, erythema nodosum, abnormal loss of hair, pruritus, skin pigmentation, lightening of hair color, lymphadenopathy, mild papular skin rashes, leukocytoclastic cutaneous vasculitis
Rare (Less than 0.1%): Vomiting
Frequency not reported: Nausea, vomiting, epigastric distress
Frequency not reported: Increase of decrease in urination
Frequency not reported: Edema
Frequency not reported: Periarteritis, arthralgia, myalgia, arthritis, myopathy, backache
Frequency not reported: Paresthesias, loss of taste, taste perversion, headache, drowsiness, neuritis, vertigo, encephalopathy, numbness or tingling of fingers, toes, or face, cerebral angiitis
Frequency not reported: Fever
Frequency not reported: Sore, red, watery eyes (recurrent keratitis, conjunctival disorders)
Frequency not reported: Acute glomerulonephritis, nephritis, glomerulonephritis
Frequency not reported: Interstitial pneumonitis, alveolar/pulmonary hemorrhage
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Propylthiouracil (www.drugs.com/mtm/propylthiouracil.html).
June 26, 2020
June 25, 2020
June 27, 2020
July 10, 2020
July 9, 2020
July 1, 2020
