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Propafenone Hydrochloride

Propafenone hydrochloride Prescription
Generic Name: propafenone (proe PAF e none)
Brand Name: Rythmol, Rythmol SR
Physician reviewed propafenone patient information - includes propafenone description, dosage and directions.
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Propafenone Hydrochloride Drug Information:

Propafenone is a Class IC anti-arrhythmic that affects the way your heart beats. Propafenone is used in certain situations to prevent serious heart rhythm disorders. Propafenone may also be used for purposes not listed in this medication guide. You should not use propafenone if you have heart failure, Brugada syndrome, sick sinus syndrome, AV block (without a pacemaker), severe low blood pressure, very slow heartbeats, a severe electrolyte imbalance, shortness of breath, or if you recently had a heart attack. Learn more

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Propafenone Hydrochloride Side Effects

In Summary

Commonly reported side effects of propafenone include: constipation, dyspnea, nausea, and dysgeusia. Other side effects include: cardiac rate disturbance, death, atrial flutter, ventricular arrhythmia, ventricular fibrillation, ventricular tachycardia, blurred vision, heart murmur, myasthenia, asthenia, diarrhea, first degree atrioventricular block, vomiting, ecchymoses, and unpleasant taste. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to propafenone: oral capsule extended release, oral tablet


Oral route (Tablet; Capsule, Extended Release)

It is prudent to consider any Class 1C antiarrhythmic to have a significant proarrhythmic risk in patients with structural heart disease. Given the lack of any evidence that these drugs improve survival, antiarrhythmic agents should generally be avoided in patients with non-life-threatening ventricular arrhythmias, even if the patients are experiencing unpleasant, but not life-threatening, symptoms or signs.

Side effects requiring immediate medical attention

Along with its needed effects, propafenone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking propafenone:

Less common

  • Chest pain
  • fast, irregular, or slow heartbeat
  • lightheadedness, dizziness, or fainting
  • shortness of breath
  • swelling of the feet or lower legs
  • weight gain


  • Chills
  • fever
  • joint pain
  • trembling or shaking
  • weakness
Side effects not requiring immediate medical attention

Some side effects of propafenone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change in taste or bitter or metallic taste

Less common

  • Blurred vision
  • constipation
  • diarrhea
  • dryness of the mouth
  • headache
  • nausea or vomiting
  • skin rash
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to propafenone: oral capsule extended release, oral tablet


Adverse reactions occurred most commonly in the cardiovascular, gastrointestinal, and nervous systems.


Common (1% to 10%): Palpitation, angina pectoris, atrial flutter, first-degree atrioventricular block, bradycardia, congestive heart failure, cardiac murmur, left bundle branch block, right bundle branch block, conduction disorders, sinus bradycardia, hypotension, wide complex tachycardia, ventricular tachycardia or ventricular fibrillation, recurrent supraventricular tachycardia

Uncommon (0.1% to 1%): Premature ventricular contractions increased

Frequency not reported: PR interval prolongation, QRS interval prolongation, unstable angina, atrial hypertrophy, cardiac arrest, coronary artery disease, extrasystoles, myocardial infarction, nodal arrhythmia, pericarditis, sinoatrial block, sinus arrest, sinus arrhythmia, supraventricular extrasystoles, ventricular extrasystoles, ventricular hypertrophy, abnormal heart sounds, abnormal pulse, carotid bruit, blood pressure decreased, blood pressure increased, limb arterial embolism, deep limb venous thrombosis, flushing, hematoma, hypertension, hypertensive crisis, labile blood pressure, pallor, peripheral coldness, peripheral vascular disease, thrombosis, intraventricular conduction delay, second-degree atrioventricular block, atrioventricular dissociation, hot flashes, sick sinus syndrome, sinus pause or arrest, supraventricular tachycardia, torsade de pointes, asystole


Very common (10% or more): Nausea and/or vomiting (11%)

Common (1% to 10%): Constipation, diarrhea, dry mouth, flatulence

Frequency not reported: Abdominal distention, abdominal pain, duodenitis, dyspepsia, dysphagia, eructation, gastritis, gastroesophageal reflux disease, gingival bleeding, glossitis, glossodynia, gum pain, halitosis, intestinal obstruction, melena, mouth ulceration, pancreatitis, peptic ulcer, rectal bleeding, gastroenteritis

Nervous system

Very common (10% or more): Unusual taste (up to 14%)

Common (1% to 10%): Dizziness, headache, tremor, somnolence, ataxia

Uncommon (0.1% to 1%): Seizures

Frequency not reported: Tinnitus, vertigo, sciatica, amnesia, balance impaired, brain damage, cerebrovascular accident, dementia, gait abnormal, hypertonia, hypoesthesia, paralysis, paresthesia, peripheral neuropathy, speech disorder, syncope, tongue hypoesthesia, memory loss, numbness, unusual smell sensation, myasthenia gravis exacerbated

Postmarketing reports: Coma


Common (1% to 10%): Dyspnea, upper respiratory tract infection, rales, wheezing

Frequency not reported: Sore throat, atelectasis, breath sounds decreased, chronic obstructive airways disease, cough, epistaxis, hemoptysis, lung disorder, pleural effusion, pulmonary congestion, respiratory failure, rhinitis, throat tightness

Postmarketing reports: Apnea


Common (1% to 10%): Chest pain, fatigue, edema, weakness

Frequency not reported: Hearing impaired, feeling hot, malaise, pain, pyrexia, breast pain, death


Common (1% to 10%): Ecchymosis

Frequency not reported: Alopecia, dermatitis, dry skin, erythema, nail abnormality, petechiae, pruritus, sweating increased, urticaria, rash, purpura


Common (1% to 10%): Hematuria

Frequency not reported: Glycosuria present, prostatic specific antigen increased, ketonuria present, proteinuria present, dysuria, nocturia, oliguria, pyuria, urinary casts, urinary frequency, urinary incontinence, urinary retention, urine abnormal, impotence, prostatism, sperm count decreased


Common (1% to 10%): Blood alkaline phosphatase increased

Frequency not reported: Hepatomegaly, ALT increased, AST increased, blood bilirubin increased, gamma-glutamyltransferase increased, cholestasis, hepatitis

Postmarketing reports: Liver abnormalities


Common (1% to 10%): Influenza

Uncommon (0.1% to 1%): Positive antinuclear antibody titer


Common (1% to 10%): Anorexia

Frequency not reported: Weight decreased, blood cholesterol increased, blood glucose increased, blood triglycerides increased, blood uric acid increased, weight increased, dehydration, diabetes mellitus, gout, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypokalemia

Postmarketing reports: Hyponatremia/inappropriate antidiuretic hormone secretion


Common (1% to 10%): Blurred vision

Frequency not reported: Eye hemorrhage, eye inflammation, eyelid ptosis, miosis, retinal disorder, visual acuity reduced, vision abnormal, eye irritation


Common (1% to 10%): Anxiety, depression

Frequency not reported: Insomnia, libido decreased, emotional disturbance, mental disorder, neurosis, nightmare, sleep disorder, abnormal dreams, confusion, psychosis/mania


Frequency not reported: Blood prolactin increased


Frequency not reported: Anemia, lymphadenopathy, spleen disorder, thrombocytopenia, hemorrhage, blood chloride decreased, blood sodium decreased, hemoglobin decreased, neutrophil count decreased, platelet count decreased, prothrombin level decreased, red blood cell count decreased, blood lactate dehydrogenase increased, eosinophil count increased, monocyte count increased, prothrombin level increased, white blood cell count increased, granulocytopenia, leukopenia

Postmarketing reports: Bleeding time increased


Frequency not reported: Blood creatinine increased, blood urea increased, renal failure, nephrotic syndrome

Postmarketing reports: Kidney failure


Common (1% to 10%): Muscle weakness

Frequency not reported: Arthritis, bursitis, collagen-vascular disease, costochondritis, joint disorder, muscle cramps, muscle spasm, myalgia, neck pain, jaw pain, tendonitis

Postmarketing reports: Lupus erythematosus

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Propafenone Hydrochloride (www.drugs.com/mtm/propafenone.html).