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Pristiq Prescription
Generic Name: desvenlafaxine (des VEN la FAX een)
Brand Names: Khedezla, Pristiq
Pristiq is used to treat major depressive disorder in adults. Learn about side effects, interactions and indications.

Average Savings for desvenlafaxine er (generic): 56.29%
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Pristiq Coupons & Prices

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Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Pristiq Drug Information:

Pristiq (desvenlafaxine) is an antidepressant belonging to a group of drugs called selective serotonin and norEpinephrine reuptake inhibitors (SNRIs). Desvenlafaxine affects chemicals in the brain that may be unbalanced in people with depression. Pristiq is used to treat major depressive disorder. Pristiq may also be used for purposes not listed in this medication guide. Do not use Pristiq within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, Linezolid, Methylene Blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Learn more

Buy Pristiq Online and Pristiq Delivery

USARx offers the following ways to purchase this medication. Choose the Best option for you!

  • Guaranteed Price

    Local Pharmacy Pickup of Pristiq

    Pay this amount and pick up your prescription at ANY Retail pharmacy of your choice! Walgreens, CVS, Walmart, etc.

  • 30-day supply
    90-day supply

    Mail Order Home Delivery of Pristiq

    The easiest way to receive your medications.

Pristiq Medicare Coverage

Pristiq Medicare Overview

Does Medicare cover Pristiq?


99% of Medicare Part D and Medicare Advantage plans cover this drug.
How much is my Pristiq co-pay with Medicare?

It depends. Which coverage stage are you in? Click on a tab below…


$15 – $201

In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.

Ways to Save on Pristiq

Here are some ways that may lower the cost of your pristiq prescription.

  • Instead of Medicare, Use a USA Rx Coupon

    If your Medicare co-pay is higher, you can save money by using a USARx coupon instead.

Pristiq Side Effects

Note: This document contains side effect information about desvenlafaxine. Some of the dosage forms listed on this page may not apply to the brand name Pristiq.

In Summary

Common side effects of Pristiq include: constipation, dizziness, drowsiness, insomnia, nausea, decreased appetite, hyperhidrosis, and xerostomia. Other side effects include: anxiety, blurred vision, mydriasis, tremor, vertigo, vomiting, abnormal dreams, chills, and yawning. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to desvenlafaxine: oral tablet extended release


Oral route (Tablet, Extended Release)

Antidepressant use has been associated with an increased risk of suicidal thinking and behavior in children, adolescents, and young adults. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared with placebo in adults aged 65 or older. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. Desvenlafaxine is not approved for use in pediatric patients.

Oral route (Tablet, Extended Release)

Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults during short-term studies. These studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults older than 24 years, and there was a reduction in risk with antidepressants compared with placebo in adults aged 65 or older. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Not approved for use in pediatric patients.

Along with its needed effects, desvenlafaxine (the active ingredient contained in Pristiq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking desvenlafaxine:

Less common

  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular pulse
  • headache
  • numbness or tingling in the arms or legs
  • shakiness in the legs, arms, hands, or feet
  • trouble thinking, speaking, or walking
  • weakness

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • blood in the stool or urine
  • chest tightness
  • cough
  • diarrhea
  • dilated or enlarged pupils (black part of the eye)
  • feeling irritated
  • fever
  • hives, itching, or rash
  • hoarseness
  • joint pain, stiffness, or swelling
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of bladder control
  • muscle pain
  • muscle spasm or jerking of all extremities
  • nosebleeds
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red skin
  • seizures
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sudden loss of consciousness
  • swelling of the eyelids, face, lips, hands, or feet
  • talking, feeling, or acting with excitement
  • trouble breathing or swallowing
  • unusual bruising
  • unusual tiredness or weakness
  • vomiting blood

Get emergency help immediately if any of the following symptoms of overdose occur while taking desvenlafaxine:

Symptoms of overdose

  • Agitation
  • bloating
  • dark urine
  • feeling of constant movement of self or surroundings
  • irregular heartbeat recurrent
  • light-colored stools
  • muscle cramp or stiffness
  • nausea
  • overactive reflexes
  • poor coordination
  • restlessness
  • seizures
  • sensation of spinning
  • shivering
  • stomach pain
  • vomiting
  • yellow eyes or skin

Some side effects of desvenlafaxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decreased appetite
  • inability to have an orgasm
  • inability to have or keep an erection
  • increased sensitivity of the eyes to light
  • loss of sexual ability, desire, drive, or performance
  • sleepiness or unusual drowsiness
  • sleeplessness

Less common

  • Change in taste
  • continuous ringing, buzzing, or other unexplained noise in the ears
  • decreased weight
  • difficult urination
  • fear or nervousness
  • hearing loss
  • jitteriness
  • lack or loss of strength
  • loss of taste

For Healthcare Professionals

Applies to desvenlafaxine: oral tablet extended release


The most commonly reported side effects were nausea, dry mouth, hyperhidrosis, and dizziness.


Very Common (10% or more): Nausea (up to 36%), dry mouth (up to 25%), constipation (up to 14%)

Common (1% to 10%): Diarrhea, vomiting

Rare (less than 0.1%): Acute pancreatitis

Frequency not reported: Gastrointestinal bleeding


Very Common (10% or more): Hyperhidrosis (up to 21%)

Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Alopecia

Rare (less than 0.1%): Photosensitivity reaction, Stevens-Johnson syndrome

Frequency not reported: Erythema multiforme, severe cutaneous reactions, toxic epidermal necrolysis

Nervous system

Very Common (10% or more): Dizziness (up to 16%), somnolence (up to 12%)

Common (1% to 10%): Disturbance in attention, dysgeusia, headache, paresthesia, tremor, vertigo

Uncommon (0.1% to 1%): Dyskinesia, extrapyramidal disorder, syncope

Rare (less than 0.1%): Convulsion, dystonia, serotonin syndrome

Frequency not reported: Seizure


Very common (10% or more): Insomnia (up to 15%)

Common (1% to 10%): Abnormal dreams, abnormal orgasm, anorgasmia, anxiety, decreased libido, irritability, nervousness, withdrawal syndrome

Uncommon (0.1% to 1%): Depersonalization, hypomania

Rare (less than 0.1%): Hallucination, mania

Frequency not reported: Bruxism, discontinuation syndrome, suicidal thoughts


Very Common (10% or more): Erectile dysfunction (up to 11%)

Common (1% to 10%): Delayed ejaculation, ejaculation disorder, ejaculation failure, proteinuria, sexual dysfunction, urinary hesitation

Uncommon (0.1% to 1%): Urinary retention


Very Common (10% or more): Fatigue (up to 11%)

Common (1% to 10%): Asthenia, chills, feeling jittery, tinnitus


Common (1% to 10%): Decreased appetite, decreased weight, elevated fasting triglycerides, elevated LDL cholesterol, elevated total cholesterol, increased blood cholesterol, increased weight

Uncommon (0.1% to 1%): Increased blood triglycerides

Rare (less than 0.1%): Hyponatremia


Ischemic cardiac adverse reactions, myocardial ischemia, myocardial infarction, and/or coronary occlusion requiring revascularization usually occurred in patients who had multiple underlying cardiac risk factors.

Common (1% to 10%): Blood pressure increased, hot flush, increased sustained hypertension, orthostatic hypotension, palpitations, tachycardia

Uncommon (0.1% to 1%): Peripheral coldness

Frequency not reported: Coronary occlusion requiring revascularization, ischemic cardiac adverse reactions, myocardial infarction, myocardial ischemia


Common (1% to 10%): Blurred vision, mydriasis

Frequency not reported: Angle closure glaucoma


Common (1% to 10%): Yawning

Uncommon (0.1% to 1%): Epistaxis

Frequency not reported: Interstitial lung disease, eosinophilic pneumonia


Common (1% to 10%): Abnormal liver function test


Common (1% to 10%): Musculoskeletal stiffness


Uncommon (0.1% to 1%): Hypersensitivity

Rare (less than 0.1%): Angioedema


Uncommon (0.1% to 1%): Increased blood prolactin


Frequency not reported: Abnormal bleeding

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Pristiq (www.drugs.com/pristiq.html).

What pharmacies accept this discount program?

Rite Aid, Wal-Mart, Walgreens, CVS, Duane Reade, Target, K-mart, and all national and regional chains across the U.S. accept the card.

What if you didn’t find your pharmacy names above?

Search our pharmacy network on our homepage and medication search results.

What if the pharmacist refuses to take the card?

If they are in the participating network, they legally have to accept and process the card. If they need help in processing the card, have them call the support phone number or email us directly.

What if the dosage, quantity, or drug name of the Pristiq coupon I downloaded is different than what I’m trying to fill right now?

Any coupon can be applied to any prescription medication at a participating pharmacy to get the lowest out of pocket cost. Prescription prices are subject to change.

Is this a drug manufacturer rebate?

No, this is not a rebate. We work with drug manufacturers like Pfizer to get the lowest out of pocket cost for medications.

Does this Pristiq coupon card work with my federal health insurance coverage, like Medicaid? What about a private insurer?

No, you must decide at the pharmacy either to use your coupon or your insurance (whether federal or from a private insurer) to get your prescription medication at the lowest out of pocket cost. 

What company owns Pristiq?

Pristiq is a product of Pfizer. USA Rx is not affiliated with Pfizer.

Who is defined as eligible patients for the coupon card?

Anyone in the U.S. and U.S. territories such as Puerto Rico are deemed eligible patients.

Pristiq Prescription Savings Explained

FAQ Disclaimer: USA Rx LLC has a full endorsement of our prescription savings discount program. This product does not replace your insurance plan. You may check the price of both your insurance plan (copay) and our patient assistance program. That is an easy step to get the lowest out of pocket cost on your prescription medications for maximum savings. Our affiliates use the “powered by USA Rx” symbol in marketing materials. If you have a medical condition and need assistance with figuring out your best option is for a discount program of prescription savings, please give us a call or drop us an email. Eligible patients should chat with their healthcare providers about possible side effects of Pristiq. Be sure to inform your doctor of any other medications you may take to treat psychiatric disorders. If you need medical help, please seek proper medical care as soon as possible. All cardholders adhere to our privacy policy and we use recent information to create our pricing estimates, which are subject to change. Prescription prices are subject to change.