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Primidone Prescription
Generic Name: primidone (PRIM i done)
Brand Name: Mysoline
Physician reviewed primidone patient information - includes primidone description, dosage and directions.

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Primidone Drug Information:

Primidone is an anticonvulsant medicine that is used to control seizures. Primidone may also be used for purposes not listed in this medication guide. Some people have thoughts about suicide while taking primidone. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Do not stop using primidone suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. You should not use primidone if you are allergic to primidone or Phenobarbital, or if you have: Learn more

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Primidone Side Effects

For the Consumer

Applies to primidone: oral tablet

Along with its needed effects, primidone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking primidone:

More common

  • Shakiness and unsteady walk
  • unsteadiness, trembling, or other problems with muscle control or coordination

Less common

  • Unusual excitement or restlessness (especially in children and in the elderly)


  • Chills
  • cough or hoarseness
  • fainting spells
  • fever and sore throat
  • fever with or without chills
  • general feeling of tiredness or weakness
  • irregular heartbeat
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • shortness of breath
  • skin rash
  • sores, ulcers, or white spots on the lips or in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking primidone:

Symptoms of overdose

  • Confusion
  • continuous, uncontrolled rolling eye movements
  • double vision
  • troubled breathing

Some side effects of primidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Clumsiness or unsteadiness
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • sensation of spinning

Less common

  • Decreased sexual ability
  • drowsiness
  • loss of appetite
  • mood or mental changes
  • nausea or vomiting

For Healthcare Professionals

Applies to primidone: oral suspension, oral tablet


Uncommon (0.1% to 1%): Allergic reactions (e.g., maculopapular, morbilliform, or scarlatiniform)

Rare (0.01% to 0.1%): Exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, lupus erythematosus


Rare (0.01% to 0.1%): Megaloblastic anemia, blood dyscrasias, granulocytopenia, agranulocytosis, red-cell hypoplasia and aplasia


Rare (0.01% to 0.1%): Arthralgia, osteomalacia, Dupuytren's contracture


Common (1% to 10%): Visual disturbances

Uncommon (0.1% to 1%): Diplopia, nystagmus


Frequency not reported: Anorexia


Uncommon (0.1% to 1%): Hyperirritability, emotional disturbances

Rare (0.01% to 0.1%): Personality changes, psychosis



Uncommon (0.1% to 1%): Sexual impotency


Rare (0.01% to 0.1%): Elevations in hepatic enzymes (e.g., gamma-glutamyl transferase [gamma GT], alkaline phosphatase)

Nervous system

Common (1% to 10%): Drowsiness, listlessness, ataxia, nystagmus, vertigo

Uncommon (0.1% to 1%): Headache, dizziness


Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Vomiting

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Primidone (www.drugs.com/mtm/primidone.html).