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Prazosin Hydrochloride

Prazosin hydrochloride Prescription
Generic Name: prazosin (PRA zoe sin)
Brand Name: Minipress
Physician reviewed prazosin patient information - includes prazosin description, dosage and directions.

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Prazosin Hydrochloride Drug Information:

Prazosin is used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Prazosin may also be used for other purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. You should not use prazosin if you are allergic to it. Tell your doctor if you have ever had: low blood pressure, especially if caused by taking medications. Learn more

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Prazosin Hydrochloride Side Effects

In Summary

Commonly reported side effects of prazosin include: dizziness. Other side effects include: syncope and drowsiness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to prazosin: oral capsule

Side effects requiring immediate medical attention

Along with its needed effects, prazosin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking prazosin:

More common

  • Dizziness or lightheadedness, especially when getting up from a lying or sitting position
  • fainting (sudden)

Less common

  • Loss of bladder control
  • pounding heartbeat
  • swelling of the feet or lower legs


  • Chest pain
  • trouble breathing

Incidence not known

  • Painful or prolonged erection of the penis
Side effects not requiring immediate medical attention

Some side effects of prazosin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Drowsiness
  • headache
  • lack of energy

Less common

  • Dryness of the mouth
  • nervousness
  • unusual tiredness or weakness


  • Frequent urge to urinate
  • nausea

For Healthcare Professionals

Applies to prazosin: compounding powder, oral capsule


The most common adverse reactions were postural hypotension, dizziness, headache, drowsiness, lack of energy, weakness, palpitations, and nausea.


Very common (10% or more): Postural hypotension (up to 14%)

Common (1% to 10%): Palpitations, tachycardia, orthostatic hypotension

Uncommon (0.1% to 1%): Angina pectoris

Rare (less than 0.1%): Bradycardia, flushing, hypotension, vasculitis

Frequency not reported: Angina exacerbation, myocardial infarction

Nervous system

Very common (10% or more): Dizziness (up to 10.3%)

Common (1% to 10%): Drowsiness, headache, faintness, syncope, vertigo

Uncommon (0.1% to 1%): Paresthesia, tinnitus

Rare (less than 0.1%): Narcolepsy worsened


Common (1% to 10%): Lack of energy, weakness, asthenia

Rare (less than 0.1%): Fever, pain

Frequency not reported: Malaise


Common (1% to 10%): Constipation, diarrhea, dry mouth, nausea, vomiting

Uncommon (0.1% to 1%): Abdominal discomfort and/or pain

Rare (less than 0.1%): Pancreatitis


Common (1% to 10%): Dyspnea, nasal congestion, epistaxis


Common (1% to 10%): Depression, nervousness

Uncommon (0.1% to 1%): Insomnia

Rare (less than 0.1%): Hallucinations


Common (1% to 10%): Blurred vision, sclera reddened

Uncommon (0.1% to 1%): Eye pain

Frequency not reported: Pigmentary mottling, serious retinopathy, cataract development, cataract disappearance


Common (1% to 10%): Urinary frequency, impotence

Rare (less than 0.1%): Incontinence, priapism


Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Diaphoresis, pruritus, urticaria

Rare (less than 0.1%): Alopecia, lichen planus


Common (1% to 10%): Edema


Uncommon (0.1% to 1%): Arthralgia


Rare (less than 0.1%): Allergic reaction, positive antinuclear antibody titer


Rare (less than 0.1%): Gynecomastia


Rare (less than 0.1%): Liver function abnormalities

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Prazosin Hydrochloride (www.drugs.com/mtm/prazosin.html).