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Praziquantel

Generic Name: praziquantel (PRAZ i KWON tel)
Brand Name: Biltricide
Physician reviewed praziquantel patient information - includes praziquantel description, dosage and directions.
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Drug Information:
Praziquantel is used to treat infections caused by schistoSoma worms, which enter the body through skin that has come into contact with contaminated water. SchistoSoma worms are found in Africa, South America, Middle Eastern countries, the Caribbean, and parts of Asia. Praziquantel is also used to treat infection with liver flukes, caused by a type of worm found in East Asia. This worm enters the body while eating contaminated fish. Praziquantel is for use in adults and children who are at least 1 year old. Learn more

Praziquantel Side Effects

Praziquantel Side Effects

For the Consumer

Applies to praziquantel: oral tablet

Along with its needed effects, praziquantel may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking praziquantel:

Incidence not known

  • Abdominal or stomach discomfort with or without nausea
  • abdominal or stomach pain
  • black, tarry stools
  • bloody diarrhea
  • chest pain or discomfort
  • chills
  • convulsions
  • cough
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • fever
  • hives
  • hoarseness
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • lightheadedness, dizziness, or fainting
  • painful or difficult urination
  • rash
  • redness of the skin
  • severe abdominal or stomach pain
  • shortness of breath
  • slow or irregular heartbeat
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • swollen glands
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing

Some side effects of praziquantel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Drowsiness
  • increased sweating
  • general feeling of discomfort or illness
  • nausea or vomiting

Less common

  • Skin rash, hives, or itching

Incidence not known

  • Difficulty with moving
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • headache
  • hives or welts
  • joint pain
  • lack or loss of strength
  • loss of appetite
  • muscle aching or cramping
  • muscle pains or stiffness
  • redness of the skin
  • sensation of spinning
  • sleepiness or unusual drowsiness
  • swollen joints
  • weight loss

For Healthcare Professionals

Applies to praziquantel: compounding powder, oral tablet

General

Side effects varied according to dose and duration of therapy. Side effects depended on parasite species, extent of infestation, infection duration, and parasite location in the body. Side effects occurred earlier and were more frequent and/or serious in patients with severe infestation.

Often, it was unclear if this drug, an endogenous reaction to parasites dying from the drug, or symptoms of the infestation caused the reported side effects.

Side effects included malaise, headache, dizziness, abdominal discomfort (with or without nausea), pyrexia, and urticaria; generally in order of severity. Such side effects were more frequent and/or serious in patients with heavy worm burden.

Nervous system

The inflammatory reaction produced by antigenic substances released from dying cysts frequently involved increased intracranial pressure, seizures, severe headaches, nausea, and vomiting. In areas where Taenia solium was endemic, these reactions may occur as the result of undiagnosed cysticercosis in patients being treated for other parasitic infections. The duration of the reaction differs among patients. Delayed reactions have been reported.

Very common (10% or more): Headache, dizziness

Common (1% to 10%): Vertigo, somnolence (including drowsiness)

Very rare (less than 0.01%): Seizures

Frequency not reported: Cerebral inflammatory reaction

Postmarketing reports: Convulsion, somnolence, vertigo, tinnitus, intention tremor

Gastrointestinal

Very common (10% or more): Gastrointestinal and abdominal pains, nausea, vomiting

Common (1% to 10%): Diarrhea

Frequency not reported: Abdominal discomfort (with or without nausea), gagging

Postmarketing reports: Abdominal pain, bloody diarrhea, vomiting

A syndrome of severe abdominal pain and bloody diarrhea was reported less often during schistosomiasis therapy.

Gagging and vomiting have been reported due to the bitter taste of the tablets.

Other

Very common (10% or more): Fatigue

Common (1% to 10%): Feeling unwell (asthenia, malaise), pyrexia/fever

Frequency not reported: Rise in temperature, transient edema

Postmarketing reports: Asthenia, fatigue, polyserositis, gait disturbance

Dermatologic

A 13-year-old male developed Mazzotti reaction after treatment with ivermectin, praziquantel, and albendazole for presumptive schistosomiasis and strongyloidiasis. Six days after receiving standard empiric therapy, he developed epigastric pain, vomiting, and urticaria. This progressed in 4 hours and included fever, general myalgia, and edema of the face, lower extremities, and penis accompanied by urticaria of the arms, legs, and trunk. He was diagnosed with a Mazzotti reaction and treated with methylprednisolone; symptoms subsided within 12 hours.

Very common (10% or more): Urticaria

Common (1% to 10%): Rash

Very rare (less than 0.01%): Pruritus

Frequency not reported: Mazzotti-like reaction

Postmarketing reports: Pruritus, rash, Stevens-Johnson syndrome

Metabolic

Common (1% to 10%)/Postmarketing reports: Anorexia

Musculoskeletal

Common (1% to 10%)/Postmarketing reports: Myalgia

Frequency not reported: Musculoskeletal aches and fatigue

Hepatic

Frequency not reported: Mild increases in liver enzymes

Postmarketing reports: Hepatitis

Cardiovascular

Very rare (less than 0.01%): Unspecified arrhythmias

Postmarketing reports: Arrhythmia (including bradycardia, ectopic rhythms, ventricular fibrillation, atrioventricular blocks)

Hypersensitivity

Postmarketing reports: Allergic reaction, generalized hypersensitivity, anaphylactic reaction

Hematologic

Postmarketing reports: Eosinophilia

Respiratory

Postmarketing reports: Pneumonitis, dyspnea, wheezing

Ocular

Postmarketing reports: Visual disturbance

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Praziquantel (www.drugs.com/mtm/praziquantel.html).