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Applies to praziquantel: oral tablet
Along with its needed effects, praziquantel may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking praziquantel:
Incidence not known
Some side effects of praziquantel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to praziquantel: compounding powder, oral tabletGeneral
Side effects varied according to dose and duration of therapy. Side effects depended on parasite species, extent of infestation, infection duration, and parasite location in the body. Side effects occurred earlier and were more frequent and/or serious in patients with severe infestation.
Often, it was unclear if this drug, an endogenous reaction to parasites dying from the drug, or symptoms of the infestation caused the reported side effects.
Side effects included malaise, headache, dizziness, abdominal discomfort (with or without nausea), pyrexia, and urticaria; generally in order of severity. Such side effects were more frequent and/or serious in patients with heavy worm burden.Nervous system
The inflammatory reaction produced by antigenic substances released from dying cysts frequently involved increased intracranial pressure, seizures, severe headaches, nausea, and vomiting. In areas where Taenia solium was endemic, these reactions may occur as the result of undiagnosed cysticercosis in patients being treated for other parasitic infections. The duration of the reaction differs among patients. Delayed reactions have been reported.
Very common (10% or more): Headache, dizziness
Common (1% to 10%): Vertigo, somnolence (including drowsiness)
Very rare (less than 0.01%): Seizures
Frequency not reported: Cerebral inflammatory reaction
Postmarketing reports: Convulsion, somnolence, vertigo, tinnitus, intention tremorGastrointestinal
Very common (10% or more): Gastrointestinal and abdominal pains, nausea, vomiting
Common (1% to 10%): Diarrhea
Frequency not reported: Abdominal discomfort (with or without nausea), gagging
Postmarketing reports: Abdominal pain, bloody diarrhea, vomiting
A syndrome of severe abdominal pain and bloody diarrhea was reported less often during schistosomiasis therapy.
Gagging and vomiting have been reported due to the bitter taste of the tablets.Other
Very common (10% or more): Fatigue
Common (1% to 10%): Feeling unwell (asthenia, malaise), pyrexia/fever
Frequency not reported: Rise in temperature, transient edema
Postmarketing reports: Asthenia, fatigue, polyserositis, gait disturbanceDermatologic
A 13-year-old male developed Mazzotti reaction after treatment with ivermectin, praziquantel, and albendazole for presumptive schistosomiasis and strongyloidiasis. Six days after receiving standard empiric therapy, he developed epigastric pain, vomiting, and urticaria. This progressed in 4 hours and included fever, general myalgia, and edema of the face, lower extremities, and penis accompanied by urticaria of the arms, legs, and trunk. He was diagnosed with a Mazzotti reaction and treated with methylprednisolone; symptoms subsided within 12 hours.
Very common (10% or more): Urticaria
Common (1% to 10%): Rash
Very rare (less than 0.01%): Pruritus
Frequency not reported: Mazzotti-like reaction
Postmarketing reports: Pruritus, rash, Stevens-Johnson syndromeMetabolic
Common (1% to 10%)/Postmarketing reports: AnorexiaMusculoskeletal
Common (1% to 10%)/Postmarketing reports: Myalgia
Frequency not reported: Musculoskeletal aches and fatigueHepatic
Frequency not reported: Mild increases in liver enzymes
Postmarketing reports: HepatitisCardiovascular
Very rare (less than 0.01%): Unspecified arrhythmias
Postmarketing reports: Arrhythmia (including bradycardia, ectopic rhythms, ventricular fibrillation, atrioventricular blocks)Hypersensitivity
Postmarketing reports: Allergic reaction, generalized hypersensitivity, anaphylactic reactionHematologic
Postmarketing reports: EosinophiliaRespiratory
Postmarketing reports: Pneumonitis, dyspnea, wheezingOcular
Postmarketing reports: Visual disturbance
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