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Pimozide works by changing the actions of chemicals in the brain.
Pimozide is used in people with Tourette's syndrome. Pimozide suppresses the physical (motor) and vocal (phonic) symptoms of tics when these symptoms interfere with daily life function.
Pimozide is not for use in treating motor tics that are not caused by Tourette's syndrome.
Pimozide may also be used for purposes not listed in this medication guide.
You should not use pimozide if you have long QT syndrome, low blood levels of potassium or magnesium, or if you take any medication that can cause tics (such as a stimulant or ADHD medication).
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can cause serious medical problems if you take them together with pimozide.
You should not use this medicine if you are allergic to pimozide or other antipsychotic medicines, or if:
you have low levels of potassium or magnesium in your blood;
you have long QT syndrome (in you or a family member); or
you take medicines that can cause tics, such as a stimulant or ADHD medication (Adderalll, Ritalin, and others).
Some medicines can cause unwanted or dangerous effects when used with pimozide. Your doctor may change your treatment plan if you also use:
ADHD medication;
an antibiotic or antifungal medication;
anti-psychotic medication;
an antidepressant;
antiviral medicines to treat hepatitis C or HIV;
anti-malaria medication;
heart rhythm medication;
medicine to prevent or treat nausea and vomiting (such as Zofran);
"triptan" migraine headache medicine (such as Imitrex or Maxalt); or
opioid medication.
Tell your doctor if you have ever had:
liver disease;
kidney disease;
seizures or epilepsy;
heart problems, high blood pressure, or a heart attack;
an enlarged prostate or urination problems; or
glaucoma.
Taking pimozide during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. Do not stop taking pimozide without your doctor's advice.
You should not breast-feed while using pimozide.
Pimozide is not approved for use by anyone younger than 12 years old.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Call your doctor if you are sick with vomiting or diarrhea. You may develop an electrolyte imbalance, which could cause heart rhythm problems while you are taking pimozide.
It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve, or if they get worse.
Your doctor will need to check your progress on a regular basis. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
Store at room temperature away from moisture, heat, and light.
Do not stop using pimozide suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using pimozide.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include muscle stiffness, shallow breathing, or feeling light-headed.
Avoid driving or hazardous activity until you know how pimozide will affect you. Your reactions could be impaired.
Drinking alcohol can increase certain side effects of pimozide.
Grapefruit may interact with pimozide and lead to unwanted side effects. Avoid the use of grapefruit products.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
High doses or long-term use of pimozide can cause a serious movement disorder that may not be reversible. The longer you use pimozide, the more likely you are to develop this disorder, especially if you are an older adult.
Call your doctor at once if you have:
uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
fever, chills, tiredness, mouth sores, skin sores;
a seizure (convulsions); or
severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
Common side effects may include:
problems with speech or vision;
drowsiness, trouble sleeping;
feeling restless;
tight muscles;
constipation; or
dry mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Tourette's Syndrome:
Initial dose: 1 to 2 mg orally per day in divided doses
Maintenance dose: Typically less than 0.2 mg/kg or 10 mg/day, whichever is less
Maximum dose: 10 mg/day
Comments:
-Use should be limited to patients with Tourette's Disorder whose development and/or daily life function is severely compromised by motor and phonic tics. This drug is not indicated for use as first-line therapy or in patients with tics that are merely annoying or cosmetically troublesome.
-Initial doses may be increased every other day if tolerated.
-Patients requiring doses greater than 4 mg/day should undergo CYP 450 2D6 genotyping.
Use: Suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond to standard treatment
Usual Pediatric Dose for Tourette's Syndrome:
12 years and older:
-Initial dose: 0.05 mg/kg orally at bedtime
-Maximum dose: 0.2 mg/kg, not to exceed 10 mg/day
Comments:
-Use should be limited to patients with Tourette's Disorder whose development and/or daily life function is severely compromised by motor and phonic tics. This drug is not indicated for use as first-line therapy or in patients with tics that are merely annoying or cosmetically troublesome.
-Doses may be increased every 3 days to a maximum of 0.2 mg/kg.
-CYP450 2D6 genotyping should be performed in patients taking greater than 0.05 mg/kg/day.
Use: Suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond to standard treatment
Pimozide can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Using pimozide with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Many drugs can affect pimozide, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Pimozide (www.drugs.com/mtm/pimozide.html).
Commonly reported side effects of pimozide include: akathisia, akinesia, sedated state, and visual disturbance. See below for a comprehensive list of adverse effects.
Applies to pimozide: oral tablet
Along with its needed effects, pimozide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking pimozide:
More common
Less common or rare
Rare
Get emergency help immediately if any of the following symptoms of overdose occur while taking pimozide:
Symptoms of overdose
Some side effects of pimozide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Applies to pimozide: oral tablet
The most common side effects include somnolence, hyperhidrosis, nocturia, and dizziness.
Very common (10% or more): Somnolence (up to 25%), dizziness (up to 11%)
Common (1% to 10%): Extrapyramidal disorder, akathisia, headache, lethargy, tremor, hyperkinesia, limb tremor, torticollis
Uncommon (0.1% to 1%): Bradykinesia, cogwheel rigidity, dyskinesia, dystonia, dysarthria
Frequency not reported: Neuroleptic malignant syndrome, grand mal convulsion, tardive dyskinesia, electroencephalogram abnormal, motor restlessness, hyperreflexia, opisthotonos, drowsiness, sedation, speech disorder, handwriting change, taste change, akinesia, parkinsonism, fainting
Postmarketing reports: Seizure
Extrapyramidal symptoms typically occurred during the first few days of treatment and involved mild to moderate Parkinson-like symptoms. This disorder is usually dose-related, with an increased occurrence and severity of symptoms with high doses; symptoms decreased or disappeared with lower doses. While these symptoms were usually reversible, a few cases of persistent symptoms required discontinuation.
Grand mal seizures occurred at doses greater than 20 mg/day.
Very common (10% or more): Adverse behavior effect (up to 22.2%)
Common (1% to 10%): Depression, agitation, insomnia, abnormal dreams, restlessness, nervous
Frequency not reported: Libido decreased/lost, excitement
Sudden, unexpected deaths have occurred at doses greater than 20 mg/day.
Very common (10% or more): Asthenia (up to 13.8%)
Common (1% to 10%): Extreme exhaustion
Uncommon (0.1% to 1%): Face edema
Frequency not reported: Neonatal drug withdrawal syndrome, body temperature dysregulation, hypothermia
Postmarketing reports: Sudden, unexplained death, hyperpyrexia, thirst
Very common (10% or more): Hyperhidrosis (up to 13%)
Common (1% to 10%): Sebaceous gland overactivity, rash
Uncommon (less than 1%): Pruritus
Frequency not reported: Urticaria, skin irritation
Very common (10% or more): Nocturia (up to 12%)
Common (1% to 10%): Urinary frequency, erectile dysfunction
Uncommon (0.1% to 1%): Amenorrhea
Frequency not reported: Galactorrhea, menstrual disorder, breast secretions, impotence
Common (1% to 10%): Constipation, dry mouth, vomiting, increased salivation/salivary hypersecretion, dysphagia
Frequency not reported: Diarrhea, nausea, gastrointestinal distress
Postmarketing reports: Gingival hyperplasia
Gingival hyperplasia occurred in animal models at high doses, but was reversible after discontinuation.
Common (1% to 10%): Muscle rigidity, myalgia
Uncommon (0.1% to 1%): Muscle spasms
Frequency not reported: Rigidity, neck rigidity, muscle cramps, muscle tightness, stooped posture
Common (1% to 10%): Vision blurred, visual disturbance
Uncommon (0.1% to 1%): Oculogyric crisis
Frequency not reported: Sensitivity of eyes to light, decrease accommodation, spots before eyes, periorbital edema, cataracts
Hyperglycemia occurred in patients with preexisting diabetes.
Common (1% to 10%): Anorexia, weight increased
Frequency not reported: Hyperglycemia, hyponatremia, appetite increase, weight loss
Electrocardiographic changes include prolongation of the QT interval, flattening/notching/inversion of the T wave, and the appearance of U waves.
Common (1% to 10%): ECG abnormal
Frequency not reported: Torsade de Pointes, ventricular tachycardia/tachycardia, ventricular fibrillation, chest pain, postural hypotension/hypotension, hypertension, palpitations
Postmarketing reports: Cardiac arrest, venous thromboembolism, deep vein thrombosis
Frequency not reported: Blood prolactin increases, gynecomastia
Frequency not reported: Glycosuria
Postmarketing reports: Hemolytic anemia
Postmarketing reports: Pulmonary embolism
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Pimozide (www.drugs.com/mtm/pimozide.html).
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