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Commonly reported side effects of pimozide include: akathisia, akinesia, sedated state, and visual disturbance. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to pimozide: oral tablet
Along with its needed effects, pimozide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking pimozide:
More common
Less common or rare
Rare
Get emergency help immediately if any of the following symptoms of overdose occur while taking pimozide:
Symptoms of overdose
Some side effects of pimozide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to pimozide: oral tablet
GeneralThe most common side effects include somnolence, hyperhidrosis, nocturia, and dizziness.
Nervous systemVery common (10% or more): Somnolence (up to 25%), dizziness (up to 11%)
Common (1% to 10%): Extrapyramidal disorder, akathisia, headache, lethargy, tremor, hyperkinesia, limb tremor, torticollis
Uncommon (0.1% to 1%): Bradykinesia, cogwheel rigidity, dyskinesia, dystonia, dysarthria
Frequency not reported: Neuroleptic malignant syndrome, grand mal convulsion, tardive dyskinesia, electroencephalogram abnormal, motor restlessness, hyperreflexia, opisthotonos, drowsiness, sedation, speech disorder, handwriting change, taste change, akinesia, parkinsonism, fainting
Postmarketing reports: Seizure
Extrapyramidal symptoms typically occurred during the first few days of treatment and involved mild to moderate Parkinson-like symptoms. This disorder is usually dose-related, with an increased occurrence and severity of symptoms with high doses; symptoms decreased or disappeared with lower doses. While these symptoms were usually reversible, a few cases of persistent symptoms required discontinuation.
Grand mal seizures occurred at doses greater than 20 mg/day.
PsychiatricVery common (10% or more): Adverse behavior effect (up to 22.2%)
Common (1% to 10%): Depression, agitation, insomnia, abnormal dreams, restlessness, nervous
Frequency not reported: Libido decreased/lost, excitement
OtherSudden, unexpected deaths have occurred at doses greater than 20 mg/day.
Very common (10% or more): Asthenia (up to 13.8%)
Common (1% to 10%): Extreme exhaustion
Uncommon (0.1% to 1%): Face edema
Frequency not reported: Neonatal drug withdrawal syndrome, body temperature dysregulation, hypothermia
Postmarketing reports: Sudden, unexplained death, hyperpyrexia, thirst
DermatologicVery common (10% or more): Hyperhidrosis (up to 13%)
Common (1% to 10%): Sebaceous gland overactivity, rash
Uncommon (less than 1%): Pruritus
Frequency not reported: Urticaria, skin irritation
GenitourinaryVery common (10% or more): Nocturia (up to 12%)
Common (1% to 10%): Urinary frequency, erectile dysfunction
Uncommon (0.1% to 1%): Amenorrhea
Frequency not reported: Galactorrhea, menstrual disorder, breast secretions, impotence
GastrointestinalCommon (1% to 10%): Constipation, dry mouth, vomiting, increased salivation/salivary hypersecretion, dysphagia
Frequency not reported: Diarrhea, nausea, gastrointestinal distress
Postmarketing reports: Gingival hyperplasia
Gingival hyperplasia occurred in animal models at high doses, but was reversible after discontinuation.
MusculoskeletalCommon (1% to 10%): Muscle rigidity, myalgia
Uncommon (0.1% to 1%): Muscle spasms
Frequency not reported: Rigidity, neck rigidity, muscle cramps, muscle tightness, stooped posture
OcularCommon (1% to 10%): Vision blurred, visual disturbance
Uncommon (0.1% to 1%): Oculogyric crisis
Frequency not reported: Sensitivity of eyes to light, decrease accommodation, spots before eyes, periorbital edema, cataracts
MetabolicHyperglycemia occurred in patients with preexisting diabetes.
Common (1% to 10%): Anorexia, weight increased
Frequency not reported: Hyperglycemia, hyponatremia, appetite increase, weight loss
CardiovascularElectrocardiographic changes include prolongation of the QT interval, flattening/notching/inversion of the T wave, and the appearance of U waves.
Common (1% to 10%): ECG abnormal
Frequency not reported: Torsade de Pointes, ventricular tachycardia/tachycardia, ventricular fibrillation, chest pain, postural hypotension/hypotension, hypertension, palpitations
Postmarketing reports: Cardiac arrest, venous thromboembolism, deep vein thrombosis
EndocrineFrequency not reported: Blood prolactin increases, gynecomastia
RenalFrequency not reported: Glycosuria
HematologicPostmarketing reports: Hemolytic anemia
RespiratoryPostmarketing reports: Pulmonary embolism
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Pimozide (www.drugs.com/mtm/pimozide.html).
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