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Perjeta

Generic Name: pertuzumab (per TOO zoo mab)
Brand Names: Perjeta
Perjeta (pertuzumab) is used together with Herceptin and docetaxel to treat breast cancer that has spread to other parts of the body. Perjeta side effects, interactions and indications.
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Drug Information:
Perjeta (pertuzumab) is a cancer medication that interferes with the growth and spread of cancer cells in the body. Perjeta is used together with other cancer medicines (trastuzumab and Docetaxel) to treat HER2-positive breast cancer. Perjeta may also be used for purposes not listed in this medication guide. Perjeta can cause birth defects or death to the unborn baby. Do not use if you are pregnant. Avoid getting pregnant while using this medicine and for at least 7 months after your last dose. Perjeta can cause life-threatening heart problems. Your heart function may need to be checked before you start using this medicine and during your treatment. Learn more

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Perjeta Side Effects

Note: This document contains side effect information about pertuzumab. Some of the dosage forms listed on this page may not apply to the brand name Perjeta.

In Summary

Common side effects of Perjeta include: anaphylaxis, cytokine release syndrome, hypersensitivity condition, and infusion related reaction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pertuzumab: intravenous solution

Warning

Intravenous route (Solution)

Pertuzumab can result in subclinical and clinical cardiac failure manifesting as decreased left ventricular ejection fraction and congestive heart failure. Evaluate cardiac function prior to and during treatment. Discontinue pertuzumab treatment for a confirmed clinically significant decrease in left ventricular function. Exposure to pertuzumab can result in embryo-fetal death and birth defects. Advise patients of these risks and the need for effective contraception.

Along with its needed effects, pertuzumab (the active ingredient contained in Perjeta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pertuzumab:

More common

  • Black, tarry stools
  • burning, numbness, tingling, or painful sensations
  • chills
  • cough
  • fast heartbeat
  • fever
  • hives, itching, or rash
  • hoarseness
  • joint pain, stiffness, or swelling
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • redness of the skin
  • sore throat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness in the arms, hands, legs, or feet

Some side effects of pertuzumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • change in taste
  • cracked lips
  • decreased appetite
  • diarrhea
  • dizziness
  • dry skin
  • ear congestion
  • hair loss or thinning of the hair
  • headache
  • loosening of the fingernails
  • loss of taste
  • loss of voice
  • nasal congestion
  • nausea
  • redness or soreness around the fingernails
  • runny nose
  • sneezing
  • vomiting
  • watering of the eyes

For Healthcare Professionals

Applies to pertuzumab: intravenous solution

Cardiovascular

Common (1% to 10%): Left ventricular dysfunction (including congestive heart failure)

Dermatologic

Very Common (10% or more): Alopecia (61%), rash (34%), nail disorder (23%), pruritus (14%)

Common (1% to 10%): Dry skin, palmar-plantar erythrodysesthesia syndrome

Gastrointestinal

Very common (10% or more): Diarrhea (67%), nausea (42%), mucositis/mucosal inflammation (28%), constipation (25%), vomiting (24%), stomatitis (19%), dyspepsia (12%)

Hematologic

Very common (10% or more): Neutropenia (53%), anemia (23%), leucopenia (20%), febrile neutropenia (13%)

Hypersensitivity

Very common (10% or more): Hypersensitivity/anaphylactic reaction, infusion reaction/cytokine release syndrome

Metabolic

Very common (10% or more): Decreased appetite (29%)

Musculoskeletal

Very common (10% or more): Myalgia (24%), arthralgia (15%), pain in extremity (15%)

Nervous system

Very common (10% or more): Peripheral neuropathy (21%), headache (21%), dysgeusia (18%), peripheral sensory neuropathy (14%), dizziness (13%)

Ocular

Very common (10% or more): Increased lacrimation (14%)

Psychiatric

Very common (10% or more): Insomnia (13%)

Respiratory

Very common (10% or more): Cough (21%), upper respiratory tract infection (17%), dyspnea (16%), nasopharyngitis (13%)

Common (1% to 10%): Paronychia, pleural effusion, epistaxis

Uncommon (0.1% to 1%): Interstitial lung disease

Other

Very common (10% or more): Fatigue (38%), peripheral edema (30%), asthenia (30%), pyrexia (19%), pain

Common (1% to 10%): Chills

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Perjeta (www.drugs.com/perjeta.html).