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More frequently reported side effects include: diarrhea and nausea. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to pantoprazole: oral packet, oral tablet enteric coated
Other dosage forms:
Along with its needed effects, pantoprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking pantoprazole:
Less common
Incidence not known
Some Side Effects Of Pantoprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Incidence not known
For Healthcare Professionals
Applies to pantoprazole: intravenous powder for injection, oral delayed release tablet, oral granule enteric coated
GeneralThe most commonly reported side effects were headache, diarrhea, and injection site thrombophlebitis (in IV formulations).
Nervous systemVery common (10% or more): Headache (Up to 26.4%), taste pervasion (Up to 18.2%)
Common (1% to 10%): Dizziness, metallic/bitter taste, somnolence
Rare (0.01% to 0.1%): Taste disorders
Very rare (less than 0.01%): Change to the sense of taste, reduced movement, speech disorder
Frequency not reported: Paresthesia, vertigo
Postmarketing reports: Ageusia, dysgeusia
Headache was a very commonly reported side effect in pediatric patients 2 to 16 years of age. In adults, headache occurred most frequently in patients given quadruple therapy (pantoprazole, bismuth, metronidazole, tetracycline) for H pylori infections, but was also very common in triple therapy (pantoprazole, amoxicillin, clarithromycin).
Taste pervasion most frequently occurred in patients given triple therapy, but it was also very common in patients given quadruple therapy.
RespiratoryVery common (10% or more): Nasopharyngitis (up to 13.6%), pharyngolaryngeal pain (up to 13.2%)
Common (1% to 10%): Cough, nasal congestion, pharyngitis
Very rare (less than 0.01%): Change to the sense of smell, dyspnea
Frequency not reported: Upper respiratory tract infection
Nasopharyngitis and pharyngolaryngeal pain occurred in pediatric patients between the ages of 2 to 16 years.
GastrointestinalDiarrhea occurred most frequently in patients given quadruple therapy (pantoprazole, bismuth, metronidazole, tetracycline) for Helicobacter pylori infections, but was also very common in triple therapy (pantoprazole, amoxicillin, clarithromycin).
Nausea, vomiting, abdominal pain, dry mouth, and constipation were more commonly reported in patients given triple therapy, compared to patients given quadruple therapy.
Fecal and/or tongue discoloration occurred more commonly in patients given quadruple therapy versus patients given triple therapy.
Very common (10% or more): Diarrhea (Up to 11.6%)
Common (1% to 10%): Abdominal pain, benign fundic gland polyps/fundic gland polyps, buccal inflammation, constipation, dry mouth, dyspepsia, fecal discoloration, flatulence, heartburn, nausea, oral moniliasis, pruritus ani, tongue discoloration, tongue pain, upper abdominal pain, vomiting
Uncommon (0.1% to 1%): Abdominal discomfort/distention, bloating, loose stools
Rare (0.01% to 0.1%): Colon polyp, rectal disorder
Very rare (less than 0.01%): Increased saliva
Frequency not reported: Clostridium difficile-associated diarrhea, severe eructation
OtherCommon (1% to 10%): Tiredness
Uncommon (0.1% to 1%): Asthenia, fatigue, malaise
Rare (0.01% to 0.1%): Body temperature increased, fever
Very rare (less than 0.01%): Pain, tinnitus
Frequency not reported: Facial edema
PsychiatricConfusion, depression, hallucinations, and disorientation, especially in predisposed patients, occurred with use, and was aggravated in patients with preexisting conditions.
Common (1% to 10%): Depression (and all aggravations)
Uncommon (0.1% to 1%): Sleep disorders
Rare (0.01% to 0.1%): Confusion (and all aggravations), disorientation (and all aggravations), hallucination (and all aggravations)
Very rare (less than 0.01%): Anxiety
Postmarketing reports: Insomnia
HepaticSevere hepatocellular damage leading to jaundice/hepatic failure is predicted to have a frequency of 1 in 1,000,000 patients.
Common (1% to 10%): Increased liver enzymes (transaminases, GGT)
Rare (0.01% to 0.1%): Increased bilirubin
Very rare (less than 0.01%): Cholestatic hepatitis, hepatitis, hepatocellular failure, jaundice
Frequency not reported: Hepatic effects, hepatocellular injury, liver function tests abnormal
Postmarketing reports: Hepatocellular damage
DermatologicCommon (1% to 10%): Exanthema/exanthemata, rash
Uncommon (0.1% to 1%): Eruption, increased sweating, pruritus
Rare (0.01% to 0.1%): Urticaria
Very rare (less than 0.01%): Erythema multiforme, flushing, Lyell syndrome, photosensitivity/photosensitivity reaction, severe skin reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)
Frequency not reported: Cutaneous lupus erythematosus, facial edema, fatal skin reactions, fatal TEN, subacute cutaneous lupus erythematosus
CardiovascularCommon (1% to 10%): Chest pain
Rare (0.01% to 0.1%): Hypertension, peripheral edema, thrombophlebitis
Very rare (less than 0.01%): Circulatory collapse, flushing, hot flushes, substernal chest pain
Frequency not reported: Generalized edema
MusculoskeletalMuscle spasm occurred as a consequence of electrolyte disturbances.
Common (1% to 10%): Arthralgia
Uncommon (0.1% to 1%): Fracture of the hip/wrist/spine
Rare (0.01% to 0.1%): Myalgia
Very rare (less than 0.01%): Skeletal pain
Frequency not reported: Bone fracture, elevated creatine phosphokinase (CPK)/elevated creatine kinase (CK), muscle spasm, systemic lupus erythematosus
Postmarketing reports: Rhabdomyolysis
MetabolicHypocalcemia occurred in association with hypomagnesemia.
Anorexia commonly occurred in patients with H pylori.
Common (1% to 10%): Anorexia
Rare (0.01% to 0.1%): Hyperlipidemia, increased cholesterol, increased triglycerides, lipid increases, weight changes
Frequency not reported: Cyanocobalamin (vitamin B12) deficiency), electrolyte disturbances, hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia, potential for exacerbation of zinc deficiency
LocalCommon (1% to 10%): Injection site thrombophlebitis
Frequency not reported: Injection site reactions
ImmunologicCommon (1% to 10%): Influenza-like symptoms, moniliasis
Rare (0.01% to 0.1%): Sepsis
HypersensitivityRare (0.01% to 0.1%): Anaphylactic reactions, anaphylactic shock, angioedema/Quincke's edema, hypersensitivity, hypersensitivity reactions
Frequency not reported: Allergic reactions
Postmarketing reports: Anaphylaxis
HematologicRare (0.01% to 0.1%): Agranulocytosis, anemia
Very rare (less than 0.01%): Increased coagulation time, leukopenia, pancytopenia, thrombocytopenia
OcularUncommon (0.1% to 1%): Blurred vision, visual disturbances
Very rare (less than 0.01%): Conjunctivitis
EndocrineRare (0.01% to 0.1%): Gynecomastia
RenalVery rare (less than 0.01%): Interstitial nephritis (with possible progression to renal failure)
Frequency not reported: Acute interstitial nephritis
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Pantoprazole Sodium (www.drugs.com/pantoprazole.html).
August 31, 2020
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