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Pamelor Prescription
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Generic Name: Nortriptyline Capsules (nor TRIP ti leen)
Brand Name: Aventyl, Pamelor
Easy-to-read patient leaflet for Pamelor. Includes indications, proper use, special instructions, precautions, and possible side effects. Average Savings for nortriptyline hydrochlori (generic): 25.43%
Generic Name: Nortriptyline Capsules (nor TRIP ti leen)
Brand Name: Aventyl, Pamelor
Easy-to-read patient leaflet for Pamelor. Includes indications, proper use, special instructions, precautions, and possible side effects. Average Savings for nortriptyline hydrochlori (generic): 25.43%
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30 tablets of Pamelor 40 mg
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Pamelor Drug Information:

This is not a list of all drugs or health problems that interact with Pamelor (nortriptyline capsules). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Pamelor (nortriptyline capsules) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Pamelor (nortriptyline capsules) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Pamelor Side Effects

Note: This document contains side effect information about nortriptyline. Some of the dosage forms listed on this page may not apply to the brand name Pamelor.

For the Consumer

Applies to nortriptyline: oral capsule, oral solution


Oral route (Capsule; Solution)

Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder and other psychiatric disorders. This risk must be balanced with the clinical need, as nortriptyline is not approved for use in pediatric patients. Closely monitor patients of all ages for clinical worsening, suicidality, or unusual changes in behavior; not approved for use in pediatric patients.

Along with its needed effects, nortriptyline (the active ingredient contained in Pamelor) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nortriptyline:

Incidence not known

  • Abdominal or stomach pain
  • agitation
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • clay-colored stools
  • cold sweats
  • confusion about identity, place, and time false beliefs that cannot be changed by facts
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased urination
  • depression
  • difficulty in passing urine (dribbling)
  • difficulty with speaking
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • double vision
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of warmth
  • feeling, seeing, or hearing things that are not there
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • general feeling of tiredness or weakness
  • hostility
  • hyperventilation
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • irritability
  • loss of balance control
  • lower back or side pain
  • mood or mental changes
  • muscle spasm or jerking of all extremities
  • muscle trembling, jerking, or stiffness
  • nightmares
  • pain or discomfort in the arms, jaw, back, or neck
  • painful or difficult urination
  • panic
  • perspiration
  • pinpoint red or purple spots on the skin
  • redness of the face, neck, arms, and occasionally, upper chest
  • restlessness
  • seizures
  • slurred speech
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the limbs
  • sweating
  • swelling of the face, ankles, legs, or hands
  • talking, feeling, and acting with excitement
  • trouble sleeping
  • twisting movements of the body uncontrolled movements, especially of the face, neck, and back
  • weakness in the arms, hands, legs, or feet

Some side effects of nortriptyline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Bigger, dilated, or enlarged pupils (black part of the eye)
  • black tongue
  • decreased interest in sexual ability or desire
  • difficulty having a bowel movement (stool)
  • enlargement of the breast
  • hair loss or thinning of the hair
  • heartburn
  • hives or welts
  • increase in sexual ability or desire
  • increased sensitivity of the eyes or skin to light
  • pain or discomfort in the chest, upper stomach, or throat
  • peculiar taste
  • severe sunburn
  • small red or purple spots on the skin
  • swelling of the testicles
  • swelling or inflammation of the mouth
  • swollen, painful, or tender lymph glands on side of face or neck
  • vision changes
  • waking to urinate at night

For Healthcare Professionals

Applies to nortriptyline: compounding powder, oral capsule, oral solution

Nervous system

Frequency not reported: Alteration in electroencephalogram (EEG) patterns, ataxia, dizziness, drowsiness, extrapyramidal symptoms, extremity paresthesia, headache, incoordination, mydriasis, numbness, peculiar taste, peripheral neuropathy, seizures, stroke, tingling, tremors


Frequency not reported: Agitation, anxiety, confusional states with hallucinations, delusions, disorientation, exacerbation of psychosis, hypomania, increased/decreased libido, insomnia, nightmares, panic, restlessness, suicidal behaviors, suicidal ideation


Frequency not reported: Abdominal cramps, black tongue, constipation, diarrhea, dry mouth, epigastric distress, gingivitis, nausea, paralytic ileus, parotid swelling, stomatitis, sublingual adenitis, tongue edema, vomiting


Frequency not reported: Arrhythmias, edema, flushing, general edema, heart block, hypertension, hypotension, myocardial infarction, palpitation, tachycardia

Postmarketing reports: Brugada syndrome


Frequency not reported: Breast enlargement, delayed micturition, dilation of the urinary tract, galactorrhea, impotence, nocturia, urinary frequency, urinary retention, testicular swelling


Frequency not reported: Alopecia, face edema, itching, perspiration, petechia, photosensitization, skin rash, urticaria


Frequency not reported: Agranulocytosis, aplastic anemia, bone marrow depression, eosinophilia, purpura, thrombocytopenia


Frequency not reported: Drug fever, fatigue, malaise, tinnitus, weakness


Frequency not reported: Altered liver function, hepatitis, jaundice (simulating obstructive), liver necrosis


Frequency not reported: Anorexia, elevation/depression of blood sugar levels, weight gain/loss


Frequency not reported: Blurred vision, disturbance of accommodation

Postmarketing reports: Angle-closure glaucoma


Frequency not reported: Gynecomastia, syndrome of inappropriate antidiuretic hormone (SIADH) secretion


Frequency not reported: Cross sensitivity (with other tricyclic drugs)


Frequency not reported: Increased risk of bone fractures

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Pamelor (www.drugs.com/pamelor.html).