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Oxybutynin Chloride

Oxybutynin chloride Prescription
Generic Name: oxybutynin (oral) (OX i BUE ti nin)
Brand Names: Ditropan XL
Oxybutynin is used to treat symptoms of overactive bladder such as incontinence. Learn about side effects, interactions and indications.

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Oxybutynin Chloride Drug Information:

Oxybutynin reduces muscle spasms of the bladder and urinary tract. Oxybutynin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, incontinence (urine leakage), and increased night-time urination. Oxybutynin may also be used for purposes not listed in this medication guide. You should not use oxybutynin if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate. Before using oxybutynin, tell your doctor if you have glaucoma, liver or kidney disease, an enlarged prostate, myasthenia gravis, ulcerative colitis, a blockage in your stomach or intestines, or a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion. Learn more

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Oxybutynin Chloride Side Effects

In Summary

Commonly reported side effects of oxybutynin include: constipation, drowsiness, and local pruritus. Other side effects include: urinary tract infection, blurred vision, dizziness, dyspepsia, headache, nausea, rhinitis, and xerophthalmia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to oxybutynin: oral syrup, oral tablet, oral tablet extended release

Other dosage forms:

  • transdermal gel/jelly, transdermal patch extended release

Along with its needed effects, oxybutynin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxybutynin:

Rare

  • Eye pain
  • skin rash or hives

Get emergency help immediately if any of the following symptoms of overdose occur while taking oxybutynin:

Symptoms of overdose

  • Clumsiness or unsteadiness
  • confusion
  • convulsions
  • dizziness
  • drowsiness (severe)
  • fainting
  • fast, slow, or irregular heartbeat
  • fever
  • flushing or redness of the face
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • troubled breathing
  • unusual excitement, nervousness, restlessness, or irritability

Some side effects of oxybutynin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • decreased sweating
  • diarrhea
  • difficulty having a bowel movement (stool)
  • drowsiness
  • dryness of the eyes, mouth, nose, or throat
  • heartburn
  • indigestion
  • runny nose
  • stomach discomfort, upset, or pain

Less common or rare

  • Blurred vision
  • decreased flow of breast milk
  • decreased sexual ability
  • difficulty in swallowing
  • feeling of warmth or heat
  • headache
  • increased sensitivity of the eyes to light
  • nausea or vomiting
  • trouble with sleeping
  • unusual tiredness or weakness

Incidence not known

- Observed during clinical practice with oxybutynin; estimates of frequency cannot be determined
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss

For Healthcare Professionals

Applies to oxybutynin: oral syrup, oral tablet, oral tablet extended release, transdermal film extended release, transdermal gel

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity

Frequency not reported: Anaphylactic reaction

Cardiovascular

Common (1% to 10%): Palpitations

Uncommon (0.1% to 1%): Cardiac arrhythmia tachycardia, vasodilation, hypertension, flushing

Frequency not reported: Heat stroke

Dermatologic

Very common (10% or more): Dry skin, pruritus

Common (1% to 10%): Flushing, rash

Frequency not reported: Angioedema, hypohidrosis

Endocrine

Postmarketing reports: Decreased lactation

Gastrointestinal

Very common (10% or more): Dry mouth (up to 72%), constipation (up to 15%), nausea

Common (1% to 10%): Diarrhea, dyspepsia, abdominal pain, vomiting, flatulence, gastroesophageal reflux disease

Uncommon (0.1% to 1%): Abdominal discomfort

Frequency not reported: Pseudo-obstruction in patients at risk (elderly or patients with constipation and treated with other drugs that decrease intestinal motility), decreased GI motility

General

The most common (incidence 5% or greater) adverse reactions were dry mouth, constipation, diarrhea, headache, somnolence, and dizziness.

Genitourinary

Common (1% to 10%): Urinary tract infection, urinary hesitation, urinary retention, dysuria, increased post void retention

Frequency not reported: Impotence, suppression of lactation, cystitis, aggravation of prostatic hypertrophy

Immunologic

Uncommon (0.1% to 1%): Fungal infection

Local

Very common (10% or more): Application site pruritus (16.8%)

Common (1% to 10%): Application site erythema, application site vesicles, application site rash, application site macules

Metabolic

Uncommon (0.1% to 1%): Anorexia, fluid retention

Musculoskeletal

Uncommon (0.1% to 1%): Back pain

Nervous system

Very common (10% or more): Dizziness (up to 17%), somnolence (up to 14%), headache, drowsiness, confusion

Common (1% to 10%): Dysgeusia

Uncommon (0.1% to 1%): Dysphagia, convulsions

Frequency not reported: Cognitive disorders in elderly, convulsions, agitation, nightmares, anxiety, paranoia, symptoms of depression, hallucinations, asthenia, insomnia, restlessness, dependence to this drug (in patients with history of drug or substance abuse)

Ocular

Common (1% to 10%): Blurred vision, dry eye, abnormal vision

Uncommon (0.1% to 1%): Angle closure glaucoma

Frequency not reported: Onset of narrow-angle glaucoma, mydriasis, intraocular hypertension, amblyopia, cycloplegia, decreased lacrimation

Other

Common (1% to 10%): Fatigue

Uncommon (0.1% to 1%): Dysphonia, thirst

Frequency not reported: Falls, accidental injury

Psychiatric

Common (1% to 10%): Insomnia, nervousness

Uncommon (0.1% to 1%): Hallucinations, confusional state, agitation, memory impairment

Frequency not reported: Psychotic disorder, anxiety, nightmares, paranoia

Respiratory

Common (1% to 10%): Cough, oropharyngeal pain, dry throat, nasal dryness

Uncommon (0.1% to 1%): Upper respiratory tract infection, rhinitis, chest discomfort, hoarseness

Rare (0.01% to 0.1%): Nasal congestion, throat irritation

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Oxybutynin Chloride (www.drugs.com/oxybutynin.html).