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Oxaliplatin

Oxaliplatin Prescription
Generic Name: oxaliplatin (ox AL i PLA tin)
Brand Name: Eloxatin
Physician reviewed oxaliplatin patient information - includes oxaliplatin description, dosage and directions.
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Oxaliplatin Drug Information:

Oxaliplatin is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Oxaliplatin is used together with other cancer medications to treat colon and rectal cancer. Oxaliplatin may also be used for purposes not listed in this medication guide. Oxaliplatin can cause a severe or life-threatening allergic reaction. Get emergency medical help if you have: hives, itching, sweating; chest pain, warmth or redness in your face, feeling light-headed; sudden cough, difficult breathing; swelling of your face, lips, tongue, or throat. Learn more

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Oxaliplatin Side Effects

In Summary

Commonly reported side effects of oxaliplatin include: peripheral neuropathy and severe peripheral neuropathy. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to oxaliplatin: intravenous powder for solution, intravenous solution

Warning

Intravenous route (Solution; Powder for Solution)

Anaphylactic reactions to oxaliplatin have been reported, and may occur within minutes of oxaliplatin administration. Epinephrine, corticosteroids, and antihistamines have been employed to alleviate symptoms.

Along with its needed effects, oxaliplatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking oxaliplatin:

More common

  • Abnormal tongue sensation
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
  • blood in the urine or stools
  • burning, prickling, itching, or tingling of the skin
  • chest pain
  • chills
  • cough
  • decreased feeling, or pain in the hands, feet, around the mouth, or throat
  • decreased urination
  • difficulty performing daily activities such as writing, buttoning, swallowing, or walking
  • difficulty with articulating words
  • difficulty with breathing
  • difficulty with moving
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • eye pain
  • fainting
  • fever
  • increase in heart rate
  • jaw spasm
  • lightheadedness
  • muscle pain or stiffness
  • numbness
  • numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet
  • pain in the chest, groin, or legs, especially the calves
  • pain in the joints
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid breathing
  • sensation of pins and needles
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stabbing pain
  • sunken eyes
  • swelling
  • swelling or inflammation of the mouth
  • swollen glands
  • thirst
  • troubled breathing with exertion
  • unusual tiredness or weakness
  • vision changes
  • wrinkled skin

Less common

  • Fast heartbeat
  • hives, itching, or skin rash
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest

Incidence not known

  • Back, leg, or stomach pains
  • blindness
  • bloated abdomen
  • blue-yellow color blindness
  • blurred vision
  • changes in patterns and rhythms of speech
  • dark urine
  • deafness
  • decreased vision
  • deep breathing
  • drowsiness
  • electric shock-like sensation that moves down the back and into the legs following a bending movement of the neck
  • general body swelling
  • increased urination
  • irregular heartbeat, recurrent
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of deep tendon reflexes
  • muscle cramps or spasms
  • muscle tremors
  • pain and fullness in the right upper abdomen
  • restlessness
  • severe constipation
  • severe diarrhea
  • severe nosebleeds
  • severe stomach cramps or tenderness
  • severe vomiting
  • trouble with speaking
  • twitches of the muscle visible under the skin
  • weakness of the muscles in your face
  • weight gain
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking oxaliplatin:

Symptoms of overdose

  • Agitation
  • coma
  • cough or hoarseness
  • diarrhea
  • disorientation
  • involuntary, rapid, or rhythmic movement of the eyes
  • lack of coordination
  • lack of sensation
  • lethargy
  • lower back or side pain
  • paralysis
  • respiratory failure
  • seizures
  • severe weakness
  • slow or irregular heartbeat
  • tremors
  • vomiting, profuse

Some side effects of oxaliplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • body aches or pain
  • ear congestion
  • feeling unusually cold, shivering
  • headache
  • heartburn
  • indigestion
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • stomach discomfort, upset, or pain
  • trouble sleeping
  • weight loss

Less common

  • Bad, unusual, or unpleasant (after) taste
  • bloated or full feeling
  • bloody nose
  • burning while urinating
  • change in taste
  • congestion
  • cracked lips
  • dryness or soreness of the throat
  • excess air or gas in stomach or intestines
  • feeling of warmth
  • hair loss
  • passing gas
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally upper chest
  • tender, swollen glands in the neck
  • thinning of the hair
  • unusual tearing of the eyes
  • voice changes

For Healthcare Professionals

Applies to oxaliplatin: intravenous powder for injection, intravenous solution

Nervous system

Very common (10% or more): Peripheral sensory neuropathy/paresthesia (92%), pharyngo-laryngeal dysesthesia (38.2%), headache (17%), taste perversion (14%), dizziness (13%), neurosensory reactions (12%), dysgeusia, rigors/tremors

Common (1% to 10%): Sensory disturbance, neuralgia, neuro NOS (not otherwise specified), vertigo, syncope, ataxia, somnolence, intracerebral bleeding, abnormal tongue sensation

Rare (less than 0.1%): Dysarthria/aphasia, RPLS/PRES

Frequency not reported: Vocal cord paralysis, aphonia/dysphonia/hoarseness, trigeminal neuralgia/facial pain, myoclonus, abnormal coordination/abnormal gait, ataxia/balance disorders

Postmarketing reports: Loss of deep tendon reflexes, Lhermitte's sign, cranial nerve palsies, fasciculations, convulsion

Hematologic

Very common (10% or more): Anemia (85.2%), leukopenia (85%), neutropenia (82.2%), granulocytopenia (78.9%), thrombocytopenia (77.4%), fever without neutropenia (33%), infection - normal ANC (10%)

Common (1% to 10%): Leukopenia, infection - low ANC, lymphopenia, febrile neutropenia, immune-allergic thrombocytopenia prolongation of prothrombin time and INR, neutropenic sepsis

Rare (less than 0.1%): Autoimmune hemolytic anemia

Postmarketing reports: Hemolytic uremic syndrome

Gastrointestinal

Very common (10% or more): Nausea (74%), diarrhea (67%), vomiting (54.1%), stomatitis/mucositis (44%), abdominal pain (33%), constipation (32%), anorexia (29%), dyspepsia (14%), diarrhea - colostomy (13%)

Common (1% to 10%): Gastrointestinal NOS (not otherwise specified), flatulence, dry mouth, rectal bleeding, rectal pain, rectal hemorrhage, gastrointestinal reflux, ascites, hemorrhoids, melena, proctitis, intestinal obstruction, gingivitis, tenesmus, enlarged abdomen, vaginal hemorrhage

Frequency not reported: Gastrointestinal bleeding

Postmarketing reports: Colitis, Clostridium difficile diarrhea, ileus, pancreatitis

Other

Very common (10% or more): Fatigue (70.3%), infection (31.6%), fever (29%), asthenia (23.4%), edema (15%), pain (15%), peripheral edema (10%)

Common (1% to 10%): Death, catheter infection, chest pain, unknown infection, feeling of chest pressure

Uncommon (0.1% to 1%): Ototoxicity

Postmarketing reports: Deafness, septic shock

Dermatologic

Very common (10% or more): Alopecia (67%), skin disorder (35.5%), sweating (12%), hand-foot syndrome (11%), rash (11%)

Common (1% to 10%): Pruritus, dry skin, nail changes, pigmentation changes, urticaria, erythematous rash, purpura

Hepatic

Very common (10% or more): Increased transaminases (57%), abnormal alkaline phosphatase (56.5%), abnormal AST (54%), abnormal ALT (36%), bilirubinemia (20%)

Postmarketing reports: Liver veno-occlusive disease/sinusoidal obstruction syndrome, perisinusoidal fibrosis

Respiratory

Very common (10% or more): Cough (35%), dyspnea (20%), epistaxis (16%), rhinitis (15%), allergic rhinitis (10%), upper respiratory tract infection (10%)

Common (1% to 10%): Hiccups, pneumonitis, other pulmonary reaction, hypoxia, pharyngitis, hemoptysis, pneumonia, bronchospasm

Rare (less than 0.1%): Acute interstitial lung disease, pulmonary fibrosis

Frequency not reported: Throat tightness/pressure/discomfort/pain

Postmarketing reports: Laryngospasm, other interstitial lung diseases

Metabolic

Very common (10% or more): Anorexia (35%), hyperglycemia (14%), hypokalemia (11%), decreased weight (11%), increased weight (10%)

Common (1% to 10%): Dehydration, hypoalbuminemia, hyponatremia, hypocalcemia, elevated creatinine, other metabolic reactions

Postmarketing reports: Metabolic acidosis

Musculoskeletal

Very common (10% or more): Back pain (19%), myalgia (14%), arthralgia (10%)

Common (1% to 10%): Bone pain, muscle weakness, involuntary muscle contractions, jaw spasm/muscle spasm/muscle contractions

Frequency not reported: Muscle twitching

Postmarketing reports: Rhabdomyolysis

Psychiatric

Very common (10% or more): Insomnia (13%)

Common (1% to 10%): Depression, anxiety, nervousness

Hypersensitivity

Very common (10% or more): Hypersensitivity reaction (12%), allergic reaction (10.3%)

Postmarketing reports: Angioedema, anaphylactic shock

Local

Very common (10% or more): Injection site reaction (11.1%)

Frequency not reported: Extravasation

Cardiovascular

Very common (10% or more): Flushing (10%)

Common (1% to 10%): Thrombosis/phlebitis, thromboembolism, hypotension, hypertension, tachycardia, hot flashes

Postmarketing reports: QT prolongation, ventricular arrhythmias, Torsade de Pointes

Genitourinary

Common (1% to 10%): Abnormal micturition frequency, dysuria, hematuria, urinary incontinence

Ocular

Common (1% to 10%): Conjunctivitis, abnormal lacrimation, abnormal vision, tearing

Rare (less than 0.1%): Optic neuritis

Frequency not reported: Ptosis, diplopia, eye pain

Postmarketing reports: Decreased visual acuity, visual field disturbance/disorders, transient/reversible vision loss

Oncologic

Common (1% to 10%): Secondary malignancies

Renal

Common (1% to 10%): Altered renal function

Very rare (less than 0.01%): Renal tubular necrosis

Postmarketing reports: Acute interstitial nephritis, acute renal failure

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Oxaliplatin (www.drugs.com/mtm/oxaliplatin.html).