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Oxacillin Sodium

Oxacillin sodium Prescription
Generic Name: oxacillin (injection) (ox a SIL in)
Brand Name: Oxacillin Sodium ADD-Vantage, Bactocill
Physician reviewed oxacillin (injection) (injection) patient information - includes oxacillin (injection) description, dosage and directions.
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Oxacillin Sodium Drug Information:

Oxacillin is a penicillin antibiotic that fights bacteria in the body. Oxacillin is used to treat many different types of infections caused by staphylococcus (also called "staph" infection). Oxacillin may also be used for purposes not listed in this medication guide. You should not use oxacillin if you are allergic to oxacillin or to any other penicillin antibiotic. You should not use this medicine if you are allergic to oxacillin or to any other penicillin antibiotic, such as: Amoxicillin, Augmentin; Learn more

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Oxacillin Sodium Side Effects

For the Consumer

Applies to oxacillin: parenteral injection, parenteral powder for injection

Side effects include:

Hypersensitivity reactions; local reactions (phlebitis, thrombophlebitis); renal, hepatic, or nervous system effects with high dosage.

For Healthcare Professionals

Applies to oxacillin: injectable powder for injection, intravenous solution, oral capsule, oral powder for reconstitution


Immediate allergic reactions usually occurred within 20 minutes of administration and ranged in severity from urticaria and pruritus to angioneurotic edema, laryngospasm, bronchospasm, hypotension, vascular collapse, and death; such immediate anaphylactic reactions were very rare and usually occurred after parenteral therapy but have occurred with oral therapy. An accelerated immediate allergic reaction has occurred between 20 minutes and 48 hours after administration and has included urticaria, pruritus, and fever; although laryngeal edema, laryngospasm, and hypotension occasionally occurred, fatality was uncommon.

Delayed allergic reactions to penicillin therapy usually occurred after 48 hours and sometimes as late as 2 to 4 weeks after starting therapy. Manifestations of this reaction included serum sickness-like symptoms (i.e., fever, malaise, urticaria, myalgia, arthralgia, abdominal pain) and various skin rashes.

Common (1% to 10%): Allergic reactions (included immediate and delayed reactions)

Rare (0.01% to 0.1%): Anaphylactic shock

Very rare (less than 0.01%): Anaphylactic shock resulting in death

Frequency not reported: Immediate allergic reaction (included urticaria, pruritus, angioneurotic edema, laryngospasm, bronchospasm, hypotension, vascular collapse, death), accelerated immediate allergic reaction (included urticaria, pruritus, fever, laryngeal edema, laryngospasm, hypotension), delayed allergic reaction (included serum sickness-like reactions [i.e., fever, malaise, urticaria, myalgia, arthralgia, abdominal pain], various skin rashes), anaphylaxis


Onset of pseudomembranous colitis symptoms have occurred during and after antibiotic therapy.

Nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, and gastrointestinal irritation have occurred, especially during oral penicillin therapy.

Frequency not reported: Pseudomembranous colitis, nausea, vomiting, diarrhea, stomatitis, black or hairy tongue, gastrointestinal irritation, Clostridium difficile-associated diarrhea


Frequency not reported: Rash, urticaria, pruritus


Frequency not reported: Neutropenia, bone marrow depression, agranulocytosis, leukopenia, thrombocytopenia, eosinophilia


Frequency not reported: Hepatotoxicity, abnormal liver function tests (mainly elevated AST levels), cholestatic jaundice, severe hepatitis, abnormal GGT serum levels

Nervous system

Neurotoxic reactions (similar to those observed with penicillin G) have occurred with large IV doses, especially in patients with renal dysfunction.

Frequency not reported: Neurotoxic reactions, seizures


Frequency not reported: Fever, abnormal alkaline phosphatase serum levels


Frequency not reported: Renal tubular damage, interstitial nephritis, renal insufficiency, nephropathy, acute renal failure


Frequency not reported: Hematuria, proteinuria


Frequency not reported: Thrombophlebitis, tissue necrosis after extravasation


Frequency not reported: Severe hypokalemia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Oxacillin Sodium (www.drugs.com/mtm/oxacillin-injection.html).