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Oseltamivir phosphate

Generic Name: oseltamivir (os el TAM ih veer)
Brand Names: Tamiflu
Oseltamivir is an antiviral medication that blocks the actions of influenza virus types A and B. Learn about side effects, interactions and indications.

Average Savings for oseltamivir phosphate (generic): 50.96%
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Drug Information:
Oseltamivir is an antiviral medication that blocks the actions of influenza virus types A and B in your body. Oseltamivir is used to treat influenza in people 2 weeks of age and older who have had flu symptoms for 2 days or less. Oseltamivir may also be given to prevent influenza in people who may have been exposed but do not yet have symptoms. This medicine will not treat the common cold. It is dangerous to purchase oseltamivir on the Internet or outside the United States. The sale and distrIbution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distrIbuted by a licensed pharmacy. Samples of "Tamiflu" purchased on the Internet have been found to contain cloxacillin, a type of antibiotic that can have dangerous side effects in people who are allergic to penicillin. Learn more

Oseltamivir phosphate Side Effects

Oseltamivir Side Effects

In Summary

Commonly reported side effects of oseltamivir include: nausea and vomiting. Other side effects include: abdominal pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to oseltamivir: oral capsule, oral powder for suspension

Along with its needed effects, oseltamivir may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oseltamivir:

Less common

  • Phlegm-producing cough
  • wheezing

Rare

  • Abdominal or stomach cramps or tenderness
  • arm, back, or jaw pain
  • bloating
  • chest pain or discomfort
  • diarrhea, watery and severe, which may also be bloody
  • drooling
  • facial swelling
  • fast or irregular heartbeat
  • hoarseness
  • increased thirst
  • pain
  • shortness of breath
  • unusual weight loss

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • convulsions (seizures)
  • dark urine
  • difficulty with swallowing
  • fainting
  • fast, slow, or irregular heartbeat
  • hives or welts
  • itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • joint or muscle pain
  • light-colored stools
  • loss of bladder control
  • loss of consciousness
  • muscle spasm or jerking of all extremities
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • skin rash or itching over the entire body
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Some side effects of oseltamivir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • nausea
  • vomiting

Less common

  • Abdominal or stomach pain
  • bloody nose or unexplained nosebleeds (occurs mainly in children)
  • burning, dry, or itching eyes (mainly in children)
  • dizziness
  • ear disorder (occurs mainly in children)
  • excessive tearing of the eyes (mainly in children)
  • redness, pain, or swelling of the eye or eyelid (mainly in children)
  • trouble with sleeping

Rare

  • Pale skin
  • troubled breathing
  • unusual bleeding or bruising

Incidence not known

  • blurred vision
  • cracked, dry, or scaly skin
  • dry mouth
  • flushed, dry skin
  • mood or mental changes
  • skin rash that is encrusted, scaly, and oozing

For Healthcare Professionals

Applies to oseltamivir: oral capsule, oral powder for reconstitution

General

The most common side effects were nausea and vomiting.

The most common side effects reported with this drug during studies for the treatment of influenza were nausea, vomiting, and headache; the most common side effects reported in prophylaxis studies were nausea, vomiting, headache, and pain. Most side effects were reported on a single occasion, occurred on the first or second day of therapy, and resolved spontaneously within 1 to 2 days.

Nervous system

Very common (10% or more): Headache (up to 17%)

Common (1% to 10%): Dizziness, vertigo

Frequency not reported: Drowsiness

Postmarketing reports: Seizure/convulsion

Side effects with similar or higher incidence among placebo patients included dizziness and vertigo.

Gastrointestinal

Very common (10% or more): Nausea

Common (1% to 10%): Vomiting, diarrhea, abdominal pain, upper abdominal pain, dyspepsia

Frequency not reported: Pseudomembranous colitis

Postmarketing reports: Gastrointestinal bleeding, hemorrhagic colitis

Side effects with similar or higher incidence among placebo patients included diarrhea, abdominal pain, upper abdominal pain, and dyspepsia.

Respiratory

Common (1% to 10%): Nasal congestion, cough, sore throat, bronchitis, nasopharyngitis, upper respiratory tract infections, influenza, rhinorrhea, sinusitis

Frequency not reported: Pneumonia, peritonsillar abscess, congestion, rhinitis, dry sore throat, epistaxis, asthma, aggravated asthma

Side effects with similar or higher incidence among placebo patients included cough, nasal congestion, sore throat, rhinorrhea, bronchitis, sinusitis, nasopharyngitis, upper respiratory tract infections, and influenza.

Psychiatric

Common (1% to 10%): Insomnia

Frequency not reported: Mania

Postmarketing reports: Abnormal behavior, delirium, altered level of consciousness, confusion, delusions, hallucinations, agitation, anxiety, nightmares, self-injury

Influenza can be associated with various neurologic and behavioral symptoms (including hallucinations, delirium, abnormal behavior), with fatal outcomes in some cases; such events may occur with encephalitis or encephalopathy but can occur without obvious severe disease. There are postmarketing reports (mostly in Japan) of delirium and abnormal behavior leading to injury, with fatal outcomes in some cases, in influenza patients using this drug. Although frequency is unknown, based on usage, these events appear uncommon. These events were primarily reported in pediatric patients, often with abrupt onset and rapid resolution. The contribution of this drug to such events has not been established.

Side effects with similar or higher incidence among placebo patients included insomnia.

Other

Side effects with similar or higher incidence among placebo patients included fatigue, pyrexia, influenza-like illness, and pain in limb.

Common (1% to 10%): Fatigue, pain, pyrexia, influenza-like illness, pain in limb, otitis media, earache

Uncommon (0.1% to 1%): Tympanic membrane disorder

Frequency not reported: Humerus fracture, malaise, sepsis, facial edema, ear disorder, accidental injury

Postmarketing reports: Hypothermia

Dermatologic

Side effects with similar or higher incidence among placebo patients included herpes simplex.

Common (1% to 10%): Herpes simplex

Uncommon (0.1% to 1%): Dermatitis (including allergic and atopic dermatitis)

Rare (less than 0.1%): Angioneurotic edema

Postmarketing reports: Rash, urticaria, eczema, serious skin reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme

Musculoskeletal

Common (1% to 10%): Back pain, arthralgia, myalgia

Side effects with similar or higher incidence among placebo patients included back pain, arthralgia, and myalgia.

Genitourinary

Side effects with similar or higher incidence among placebo patients included dysmenorrhea.

Common (1% to 10%): Dysmenorrhea

Ocular

Common (1% to 10%): Conjunctivitis (including red eyes, eye discharge, eye pain)

Postmarketing reports: Visual disturbances

Hepatic

Uncommon (0.1% to 1%): Elevated liver enzymes

Rare (less than 0.1%): Hepatic failure, fulminant hepatitis (including fatalities)

Frequency not reported: Hepatic function disorder, jaundice

Postmarketing reports: Hepatitis, abnormal liver function tests

Hypersensitivity

Postmarketing reports: Hypersensitivity reactions (e.g., allergic skin reactions), allergy, anaphylactic/anaphylactoid reactions, swelling of the face or tongue

Cardiovascular

Uncommon (0.1% to 1%): Cardiac arrhythmia

Frequency not reported: Unstable angina, sudden cardiopulmonary arrest

Postmarketing reports: Arrhythmia

Metabolic

Frequency not reported: Hyperglycemia

Postmarketing reports: Aggravation of diabetes

Hematologic

Frequency not reported: Anemia, pancytopenia, lymphadenopathy

Postmarketing reports: Thrombocytopenia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Oseltamivir Phosphate (www.drugs.com/oseltamivir.html).