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Orencia

Generic Name: abatacept (a BAY ta sept)
Brand Names: Orencia
Orencia is used to treat the symptoms of rheumatoid arthritis and to slow the progression of joint damage. Learn about side effects, interactions and indications.
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Drug Information:
Orencia (abatacept) a protein that prevents your body's immune system from attacking healthy tissues such as joints. The immune system helps your body fight infections. In people with autoimmune disorders, the immune system mistakes the body's own cells for invaders and attacks them. Orencia is a prescription medicine used to treat the symptoms of rheumatoid arthritis, and to prevent joint damage caused by these conditions. This medicine is for adults and children who are at least 2 years old. Orencia is not a cure for any autoimmune disorder and will only treat the symptoms of your condition. Learn more

Orencia Side Effects

Orencia Side Effects

Note: This document contains side effect information about abatacept. Some of the dosage forms listed on this page may not apply to the brand name Orencia.

In Summary

Common side effects of Orencia include: headache and nasopharyngitis. Other side effects include: dyspepsia and hypertension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to abatacept: powder for solution, solution

Along with its needed effects, abatacept (the active ingredient contained in Orencia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking abatacept:

More common

  • Back pain
  • bladder pain
  • bloody or cloudy urine
  • body aches or pain
  • chills
  • cough
  • cough producing mucus
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • dizziness
  • ear congestion
  • fever
  • frequent urge to urinate
  • headache
  • loss of voice
  • lower back or side pain
  • nausea or vomiting
  • noisy breathing
  • pain or tenderness around the eyes and cheekbones
  • sneezing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest
  • troubled breathing
  • unusual tiredness or weakness

Less common

  • Blurred vision
  • burning or stinging of the skin
  • chest pain
  • nervousness
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • pounding in the ears
  • skin rash
  • slow or fast heartbeat

Rare

  • Confusion
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • flushing
  • hives or welts
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • stomach pain or tenderness
  • sweating
  • swelling of the face, throat, or tongue

Incidence not known

  • Redness, soreness, or itching of the skin
  • sores, welts, blisters

Some side effects of abatacept may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • heartburn
  • indigestion
  • stomach discomfort or upset

Less common

  • Diarrhea
  • pain in the arms or legs

For Healthcare Professionals

Applies to abatacept: intravenous powder for injection, subcutaneous solution

Respiratory

Very common (10% or more): Upper respiratory tract infection (including tracheitis, nasopharyngitis)

Common (1% to 10%): Lower respiratory tract infection (including bronchitis), rhinitis, pneumonia, cough, sinusitis

Uncommon (0.1% to 1%): Bronchospasm, wheezing, dyspnea

Rare (less than 0.1%): Throat tightness, bacterial pneumonia, influenza pneumonia

Frequency not reported: Tracheitis

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity

Oncologic

Frequency not reported: Cancer of lung, skin, breast, bile duct, bladder, cervical, endometrial, lymphoma, melanoma, myelodysplastic syndrome, ovarian, prostate, renal, thyroid, uterus

Immunologic

Common (1% to 10%): Herpes infections (including herpes simplex, oral herpes, and herpes zoster), influenza

Uncommon (0.1% to 1%): Streptococcal sepsis

Rare (less than 0.1%): Tuberculosis, bacteremia

Gastrointestinal

Common (1% to 10%): Abdominal pain, diarrhea, nausea, dyspepsia, mouth ulceration, aphthous stomatitis, vomiting

Uncommon (0.1% to 1%): Tooth infection, gastritis, weight increased

Rare (less than 0.1%): Gastrointestinal infection, diverticulitis, peridiverticular abscess

Genitourinary

Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Pelvic inflammatory disease, amenorrhea, menorrhagia

Dermatologic

Common (1% to 10%): Rash (including dermatitis), alopecia, pruritus

Uncommon (0.1% to 1%): Onychomycosis, skin abscess

Frequency not reported: Dry skin, cellulitis, increased tendency to bruise, infected skin ulcers

Nervous system

Very common (10% or more): Headache (12%)

Common (1% to 10%): Dizziness, paresthesia

Uncommon (0.1% to 1%): Migraine

Frequency not reported: Vertigo

Local

Common (1% to 10%): Local injection site reactions

Cardiovascular

Common (1% to 10%): Hypertension, flushing

Uncommon (0.1% to 1%): Palpitations, tachycardia, bradycardia, hypotension, hot flush, vasculitis, hypotension

Hepatic

Common (1% to 10%): Liver function test abnormal (including transaminases increased)

Frequency not reported: abnormal liver function tests and increased transaminases

Hematologic

Common (1% to 10%): Leukopenia

Uncommon (0.1% to 1%): Thrombocytopenia

Metabolic

Frequency not reported: Weight gain

Musculoskeletal

Common (1% to 10%): Pain in extremity

Uncommon (0.1% to 1%): Musculoskeletal infections, arthralgia

Ocular

Common (1% to 10%): Conjunctivitis

Uncommon (0.1% to 1%): Dry eye, visual acuity reduced

Psychiatric

Uncommon (0.1% to 1%): Depression, anxiety, sleep disorder (including insomnia)

Renal

Uncommon (0.1% to 1%): Pyelonephritis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Orencia (www.drugs.com/orencia.html).