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Generic Name: pegaspargase (peg ah SPAR jase)
Brand Name: Oncaspar
Physician reviewed Oncaspar patient information - includes Oncaspar description, dosage and directions.
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Drug Information:
Oncaspar is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Oncaspar is used in combination with other cancer medications to treat acute lymphoblastic leukemia. Oncaspar is also used to treat allergic Reactions to another cancer medication called asparaginase (Elspar). Oncaspar may also be used for purposes not listed in this medication guide. You should not use Oncaspar if you have ever received asparaginase and it caused pancreatitis, severe bleeding, a blood clot, or a severe allergic Reaction. Learn more

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Oncaspar Side Effects

Note: This document contains side effect information about pegaspargase. Some of the dosage forms listed on this page may not apply to the brand name Oncaspar.

For the Consumer

Applies to pegaspargase: parenteral injection

Side effects include:

Hypersensitivity reactions, coagulopathy, hyperglycemia, elevated serum transaminase concentrations, hyperbilirubinemia, pancreatitis, CNS thrombosis. No apparent difference in adverse effects following IV versus IM administration.

For Healthcare Professionals

Applies to pegaspargase: injectable solution


The most commonly reported side effects were elevated transaminases and clinical allergic reactions to asparaginase (including bronchospasm, hypotension, laryngeal edema, local erythema or swelling, systemic rash, and urticaria).


Very common (10% or more): Hypersensitivity, urticaria, anaphylactic reaction

Nervous system

Common (1% to 10%): Central nervous system thrombosis/hemorrhage, seizure, peripheral motor neuropathy, syncope

Rare (less than 0.1%): Posterior reversible leukoencephalopathy syndrome

Frequency not reported: Somnolence, tremor


Common (1% to 10%): Thrombosis, embolism


Very common (10% or more): Pancreatitis, diarrhea, abdominal pain, nausea

Common (1% to 10%): Vomiting, stomatitis, ascites

Rare (less than 0.1%): Pancreatitis necrotizing, pancreatitis hemorrhagic

Frequency not reported: Pancreatic pseudocyst, parotitis


Very common (10% or more): Febrile neutropenia

Common (1% to 10%): Coagulopathy (prolonged prothrombin time or partial thromboplastin time; or hypofibrinogenemia), anemia

Frequency not reported: Bone marrow failure


Very common (10% or more): Elevated transaminases

Common (1% to 10%): Hyperbilirubinemia, hepatotoxicity, fatty liver

Rare (0.01% to 0.1%): Hepatic necrosis, jaundice, cholestasis, hepatic failure


Common (1% to 10%): Hyperglycemia, weight decreased, decreased appetite

Frequency not reported: Glucose intolerance, hyperlipidemia, hypercholesterolemia, diabetic ketoacidosis, hypoglycemia


Common (1% to 10%): Infections, sepsis


Common (1% to 10%): Pain in extremities


Frequency not reported: Confusion


Common (1% to 10%): Hypoxia


Frequency not reported: Pyrexia


Frequency not reported: Acute renal failure


Very common (10% or more): Rash

Frequency not reported: Toxic epidermal necrolysis (TEN), cerebrovascular accident, hemorrhage, superior sagittal sinus thrombosis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Oncaspar (www.drugs.com/mtm/oncaspar.html).