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Generic Name: amoxicillin, clarithromycin, and omeprazole (a MOX i SIL in, kla RITH roe MYE sin, oh MEP ra zole)
Brand Name: Omeclamox-Pak
Physician reviewed Omeclamox-Pak patient information - includes Omeclamox-Pak description, dosage and directions.
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Drug Information:
Amoxicillin is a penicillin antibiotic. Clarithromycin is a macrolide antibiotic. These antibiotics fight bacteria in the body. Omeprazole decreases the amount of acid produced in the stomach. OmeClamox-Pak is a combination medicine used to prevent stomach ulcer caused by infection with Helicobacter pylori (H. pylori). OmeClamox-Pak may also be used for purposes not listed in this medication guide. You should not take OmeClamox-Pak if you've ever had a severe allergic Reaction to certain antibiotics. Learn more

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Omeclamox-pak Side Effects

Note: This document contains side effect information about amoxicillin / clarithromycin / omeprazole. Some of the dosage forms listed on this page may not apply to the brand name Omeclamox-Pak.

For the Consumer

Applies to amoxicillin / clarithromycin / omeprazole: oral capsule, oral capsule delayed release, oral tablet

Along with its needed effects, amoxicillin/clarithromycin/omeprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin / clarithromycin / omeprazole:

Incidence not known

  • Abdominal or stomach tenderness, cramps, or pain
  • blistering, peeling, or loosening of the skin
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever or chills
  • hives or welts, itching, or skin rash
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle pain or weakness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • redness of the skin
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the body, feet, and ankles
  • tightness in the chest
  • unusual tiredness or weakness
  • unusual weight gain
  • watery and severe diarrhea, which may also be bloody

Some side effects of amoxicillin / clarithromycin / omeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • headache

For Healthcare Professionals

Applies to amoxicillin / clarithromycin / omeprazole: oral kit


The most commonly reported side effects included diarrhea, taste perversion, and headache.

Clarithromycin: The most commonly reported side effects included diarrhea, nausea, and abnormal taste.

Omeprazole: The most commonly reported side effects included headache, abdominal pain, and nausea.


Very common (10% or more): Diarrhea (up to 14%), taste perversion (up to 10%)

Frequency not reported: Clostridium difficile-associated diarrhea


Postmarketing reports: Diarrhea, hemorrhagic/Clostridium difficile-associated colitis, nausea, tooth discoloration, vomiting


Common (1% to 10%): Abdominal pain/discomfort, diarrhea, dyspepsia, nausea

Postmarketing reports: Glossitis, oral moniliasis, pancreatitis, stomatitis, tooth/tongue discoloration, vomiting


Common (1% to 10%): Abdominal pain, acid regurgitation, constipation, diarrhea, flatulence, nausea, vomiting

Postmarketing reports: Abdominal swelling, dry mouth, esophageal candidiasis, fecal discoloration, gastric fundic gland polyps, irritable colon, mucosal atrophy of the tongue, pancreatitis/fatal pancreatitis, stomatitis

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Myasthenia gravis


Postmarketing reports: Dizziness, reversible hyperactivity


Common (1% to 10%): Abnormal taste, headache

Postmarketing reports: Altered sense of smell, convulsions, dizziness, taste perversion/loss, tremor, vertigo


Common (1% to 10%): Dizziness, headache

Postmarketing reports: Hepatic encephalopathy, paresthesia, somnolence, taste perversion, tremors, vertigo


Postmarketing reports: Hypersensitivity


Postmarketing reports: Allergic reactions, anaphylaxis


Postmarketing reports: Anaphylactic shock, anaphylaxis, angioedema, hypersensitivity reactions



Postmarketing reports: Elevated alkaline phosphatase/lactate dehydrogenase


Very rare (less than 0.01%): Anorexia

Postmarketing reports: Hypoglycemia


Postmarketing reports: Anorexia, hypoglycemia, hyponatremia, weight gain



Postmarketing reports: Acute generalized exanthematous pustulosis, erythema multiforme, erythematous maculopapular rashes, exfoliative dermatitis, hypersensitivity vasculitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria


Postmarketing reports: Mild skin eruptions, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria


Common (1% to 10%): Rash

Postmarketing reports: Alopecia, dry skin, erythema hyperhidrosis, multiforme, petechia, photosensitivity, severe generalized skin reactions, skin inflammation pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis/fatal toxic epidermal necrolysis, urticaria



Postmarketing reports: Acute cytolytic hepatitis, AST/ALT/GGT/total bilirubin elevation, cholestatic jaundice, hepatic dysfunction, hepatic cholestasis


Postmarketing reports: Cholestatic/hepatocellular hepatitis with/without jaundice, hepatic dysfunction, haptic failure with fatal outcome, increased liver enzymes


Postmarketing reports: Cholestatic disease, hepatic failure/fatal hepatic failure, hepatocellular disease, jaundice, liver disease, liver necrosis/fatal liver necrosis, liver function test elevations (e.g., AST, ALT, bilirubin, GGT, alkaline phosphatase), mixed hepatitis



Postmarketing reports: Agranulocytosis, anemia, decreased white blood cells, eosinophilia, hemolytic anemia, increased prothrombin time, leukopenia, thrombocytopenia, thrombocytopenic purpura


Postmarketing reports: Leukopenia, neutropenia, thrombocytopenia


Postmarketing reports: Agranulocytosis/fatal agranulocytosis, anemia, hemolytic anemia, leukocytosis, leukopenia, neutropenia, pancytopenia, purpura, thrombocytopenia



Postmarketing reports: Agitation, anxiety, behavioral changes, confusion, insomnia


Postmarketing reports: Anxiety, behavioral changes, confusional state, depersonalization, disorientation, hallucinations, insomnia, manic behavior, nightmares, psychosis


Postmarketing reports: Aggression, agitation, anxiety, apathy, confusion, depression, dream abnormalities, hallucination, insomnia, nervousness, psychiatric and sleep disturbances



Postmarketing reports: Elevated blood urea nitrogen (BUN)/serum creatinine


Postmarketing reports: Interstitial nephritis


Postmarketing reports: Glycosuria, increased serum creatinine, interstitial nephritis



Postmarketing reports: Hearing loss, tinnitus


Common (1% to 10%): Asthenia

Postmarketing reports: Fatigue, fever, malaise, pain, tinnitus



Postmarketing reports: QT prolongation, torsade de pointes, ventricular arrhythmia/tachycardia


Postmarketing reports: Angina, blood pressure elevation, bradycardia, chest pain palpitations, peripheral edema, tachycardia



Postmarketing reports: Crystalluria


Postmarketing reports: Hematuria, microscopic pyuria, proteinuria, testicular pain, urinary frequency, urinary tract infection



Common (1% to 10%): Cough, Upper respiratory tract infection

Postmarketing reports: Bronchospasm, epistaxis, pharyngeal pain



Common (1% to 10%): Back pain

Postmarketing reports: Joint pain, leg pain, muscle cramps/weakness, myalgia



Postmarketing reports: Anterior ischemic optic neuropathy, blurred vision, double vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis



Postmarketing reports: Gastroduodenal carcinoma



Postmarketing reports: Gynecomastia



Frequency not reported: Serum sickness-like reaction

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Omeclamox-pak (www.drugs.com/mtm/omeclamox-pak.html).