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Ofirmev

Generic Name: acetaminophen (injection) (a SEET a MIN oh FEN)
Brand Names: Ofirmev
Ofirmev (acetaminophen injection) is used to treat acute pain and to reduce fever in adults and children. Includes Ofirmev side effects, interactions and indications.
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Drug Information:
Ofirmev (Acetaminophen injection) is a pain reliever and a fever reducer. Ofirmev is used to treat pain and to reduce fever. It is sometimes given with opioid (sometimes called narcotic) pain medication to treat moderate to severe pain. Ofirmev may also be used for purposes not listed in this medication guide. You should not use Ofirmev if you have severe liver disease. Do not use more Ofirmev than is recommended. An overdose of Acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, Clay-colored stools, or jaundice (yellowing of your skin or eyes). Learn more

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Ofirmev Side Effects

Note: This document contains side effect information about acetaminophen. Some of the dosage forms listed on this page may not apply to the brand name Ofirmev.

In Summary

More frequent side effects include: fever. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to acetaminophen: capsule, capsule liquid filled, elixir, liquid, powder, solution, suppository, suspension, syrup, tablet, tablet chewable, tablet disintegrating, tablet extended release

Other dosage forms:

  • intravenous solution

Along with its needed effects, acetaminophen (the active ingredient contained in Ofirmev) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acetaminophen:

Rare

  • Bloody or black, tarry stools
  • bloody or cloudy urine
  • fever with or without chills (not present before treatment and not caused by the condition being treated)
  • pain in the lower back and/or side (severe and/or sharp)
  • pinpoint red spots on the skin
  • skin rash, hives, or itching
  • sore throat (not present before treatment and not caused by the condition being treated)
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden decrease in the amount of urine
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen:

Symptoms of overdose

  • Diarrhea
  • increased sweating
  • loss of appetite
  • nausea or vomiting
  • stomach cramps or pain
  • swelling, pain, or tenderness in the upper abdomen or stomach area

For Healthcare Professionals

Applies to acetaminophen: compounding powder, intravenous solution, oral capsule, oral granule effervescent, oral liquid, oral powder for reconstitution, oral suspension, oral tablet, oral tablet chewable, oral tablet disintegrating, oral tablet extended release, rectal suppository

General

In general, acetaminophen (the active ingredient contained in Ofirmev) is well-tolerated when administered in therapeutic doses. The most commonly reported adverse reactions have included nausea, vomiting, constipation. Injection site pain and injection site reaction have been reported with the IV product.

Hepatic

Common (1% to 10%): Increased aspartate aminotransferase

Rare (less than 0.1%): Increased hepatic transaminases

Frequency not reported: Liver failure

Gastrointestinal

Very common (10% or more): Nausea (up to 34%), Vomiting (up to 15%)

Common (1% to 10%): Abdominal pain, diarrhea, constipation, dyspepsia, enlarged abdomen

Frequency not reported: Dry mouth

Hypersensitivity

Postmarketing reports: Anaphylaxis, hypersensitivity reactions

Hematologic

Common (1% to 10%): Anemia, postoperative hemorrhage

Very rare (less than 0.01%): Thrombocytopenia, leucopenia, neutropenia

Dermatologic

Common (1% to 10%): Rash, pruritus

Rare (less than 0.1%): Serious skin reactions such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and toxic epidermal necrolysis

Very rare (less than 0.01%): Pemphigoid reaction, pustular rash, Lyell syndrome

Respiratory

Common (1% to 10%): Dyspnea, abnormal breath sounds, pulmonary edema, hypoxia, pleural effusion, stridor, wheezing, coughing

Cardiovascular

Common (1% to 10%): Peripheral edema, hypertension, hypotension, tachycardia, chest pain

Metabolic

Common (1% to 10%): Hypokalemia, hyperglycemia

Nervous system

Common (1% to 10%): Headache, dizziness

Frequency not reported: Dystonia

Musculoskeletal

Common (1% to 10%): Muscle spasms, trismus

Psychiatric

Common (1% to 10%): Insomnia, anxiety

Genitourinary

Common (1% to 10%): Oliguria

Local

Common (1% to 10%): Infusion site pain, injection site reactions

Ocular

Common (1% to 10%): Periorbital edema

Other

Common (1% to 10%): Pyrexia, fatigue

Rare (0.01% to 0.1%): Malaise

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Ofirmev (www.drugs.com/ofirmev.html).