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Note: This document contains side effect information about ethinyl estradiol / etonogestrel. Some of the dosage forms listed on this page may not apply to the brand name NuvaRing.For the Consumer
Applies to ethinyl estradiol/etonogestrel: vaginal insert extended release
Vaginal route (Insert, Extended Release)
Women over 35 years old who smoke should not use etonogestrel/ethinyl estradiol vaginal ring. Cigarette smoking increases the risk of serious cardiovascular events from combination hormonal contraceptive use.
Along with its needed effects, ethinyl estradiol / etonogestrel may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ethinyl estradiol / etonogestrel:
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking ethinyl estradiol / etonogestrel:
Symptoms of overdose
Some side effects of ethinyl estradiol / etonogestrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to ethinyl estradiol / etonogestrel: vaginal ringGeneral
Adverse reactions leading to study discontinuation occurred in 13% of the women during clinical trials. The most common adverse reactions leading to discontinuation were device-related events (2.7%), mood changes (1.7%), headache/migraine (1.5%), and vaginal symptoms (1.2%).Genitourinary
Very common (10% or more): Vaginitis (13.8%)
Common (1% to 10%): Vaginal discharge, vaginal discomfort, breast pain/discomfort/tenderness, dysmenorrhea, genital pruritus, vaginal discomfort, pelvic pain, leucorrhoea, vaginal infection
Uncommon (0.1% to 1%): Dysuria, micturition urgency, pollakiuria, urinary tract infection, amenorrhea, breast enlargement, breast mass, cervical polyp, cervicitis, coital bleeding, coital discomfort, dyspareunia, ectropion of cervix, fibrocystic breast disease, menorrhagia, metrorrhagia, pelvic discomfort, premenstrual syndrome, uterine spasm, vaginal burning sensation, vaginal odor, vaginal pain, vulvovaginal discomfort, vulvovaginal dryness
Frequency not reported: Penile disorder, galactorrhea, uterine bleeding irregular
Postmarketing reports: Local reaction to penis, vaginal injury (including associated pain, discomfort, and bleeding) associated with ring breakageCardiovascular
In studies that were required or sponsored by regulatory agencies, this combined hormonal combination vaginal ring showed a VTE risk similar to combined oral contraceptive use (8.3 per 10,000 women-years versus 9.2 per 10,000 women-years).
Uncommon (0.1% to 1%): Blood pressure increased, hot flush
Rare (less than 0.1%): Venous thromboembolism, arterial thromboembolism
Frequency not reported: Deep vein thrombosis
Postmarketing reports: Arterial event, myocardial infarction, varicose vein aggravatedHypersensitivity
Frequency not reported: Anaphylaxis, angioedemaLocal
Common (1% to 10%): Medical device discomfort, discomfort/foreign body sensationGastrointestinal
Common (1% to 10%): Nausea/vomiting, abdominal pain, diarrhea, toothache
Uncommon (0.1% to 1%): Abdominal distention, constipation, abdomen enlargedOncologic
Uncommon (0.1% to 1%): Breast fibroadenosis
Frequency not reported: Hormone dependent tumors, liver tumorRespiratory
Common (1% to 10%): Bronchitis, coughing, pharyngitis, rhinitis, sinusitis, upper respiratory tract infectionDermatologic
Common (1% to 10%): Acne
Uncommon (0.1% to 1%): Pruritus, rash, alopecia, eczema
Frequency not reported: Urticaria, chloasma
Postmarketing reports: AngioedemaHepatic
Frequency not reported: Cholelithiasis, liver diseaseOcular
Uncommon (0.1% to 1%): Visual disturbanceImmunologic
Common (1% to 10%): Allergic reaction
Frequency not reported: Hypersensitivity
Postmarketing reports: AnaphylaxisMusculoskeletal
Common (1% to 10%): Back pain
Uncommon (0.1% to 1%): Muscle spasm, pain in extremityMetabolic
Uncommon (0.1% to 1%): Appetite increasedPsychiatric
Common (1% to 10%): Mood changed/altered, depression, mood swings, affect lability, libido decreased
Uncommon (0.1% to 1%): Anxiety, irritabilityOther
Common (1% to 10%): Expulsion of contraceptive device, device-related event, weight increased, fatigue, fever, influenza-like symptoms
Uncommon (0.1% to 1%): Device breakage, device complication, cervicitis, herpes simplex, malaise, edemaNervous system
Very common (10% or more): Headache/migraine (11.2%)
Uncommon (0.1% to 1%): Dizziness, hypoesthesia
Postmarketing reports: Stroke/cerebrovascular accidentRenal
Uncommon (0.1% to 1%): Cystitis
July 31, 2020
June 22, 2020
October 13, 2021
October 13, 2021
October 8, 2021
October 8, 2021
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No, you must decide at the pharmacy either to use your free pharmacy coupon or your insurance.
Nuvaring is produced by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. Merck & Co., Inc. is an American pharmaceutical company based out of New Jersey. Their website is intended for us only my residents of the United States and Puerto Rico.