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Nuvaring Prescription
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Generic Name: ethinyl estradiol and etonogestrel (vaginal ring) (ETH in il es tra DYE ole and et oh noe JES trel)
Brand Names: NuvaRing
Nuvaring (ethinyl estradiol and etonogestrel) is a vaginal ring used as contraception to prevent pregnancy. Includes Nuvaring side effects, interactions and indications.
Generic Name: ethinyl estradiol and etonogestrel (vaginal ring) (ETH in il es tra DYE ole and et oh noe JES trel)
Brand Names: NuvaRing
Nuvaring (ethinyl estradiol and etonogestrel) is a vaginal ring used as contraception to prevent pregnancy. Includes Nuvaring side effects, interactions and indications.
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1 tablets of Nuvaring 40 mg
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Nuvaring Drug Information:

The NuvaRing vaginal ring contains a combination of ethinyl Estradiol and etonogestrel are female hormones that prevent ovulation (the release of an egg from an ovary). The hormones in NuvaRing also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus. The NuvaRing vaginal ring is used as contraception to prevent pregnancy. Do not use a NuvaRing if you are pregnant or if you have recently had a baby. Learn more

Nuvaring Side Effects

Note: This document contains side effect information about ethinyl estradiol / etonogestrel. Some of the dosage forms listed on this page may not apply to the brand name NuvaRing.

For the Consumer

Applies to ethinyl estradiol/etonogestrel: vaginal insert extended release


Vaginal route (Insert, Extended Release)

Women over 35 years old who smoke should not use etonogestrel/ethinyl estradiol vaginal ring. Cigarette smoking increases the risk of serious cardiovascular events from combination hormonal contraceptive use.

Along with its needed effects, ethinyl estradiol / etonogestrel may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ethinyl estradiol / etonogestrel:

Incidence not known

  • Blurred vision
  • changes in skin color
  • chest pain or discomfort
  • confusion
  • constipation
  • diarrhea
  • dizziness
  • gaseous stomach pain
  • headache
  • inability to speak
  • nausea
  • nervousness
  • numbness of the hands
  • pain in the chest, groin, or legs, especially calves of the legs
  • pain or discomfort in the arms, jaw, back, or neck
  • pounding in the ears
  • prominent superficial veins over the affected area with tenderness and warmth
  • recurrent fever
  • seizures
  • severe headache of sudden onset
  • slow or fast heartbeat
  • stomach fullness
  • stomach pain or tenderness usually after eating a meal
  • sudden loss of coordination
  • sudden onset of slurred speech
  • sudden vision changes
  • sudden and severe weakness in the arm or leg on one side
  • sweating
  • swelling of the foot or leg on one side of the body
  • temporary blindness
  • vomiting with or without blood
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking ethinyl estradiol / etonogestrel:

Symptoms of overdose

  • Menstrual changes
  • nausea
  • vaginal bleeding

Some side effects of ethinyl estradiol / etonogestrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Cough
  • fever
  • itching of the vagina or genital area
  • pain during sexual intercourse
  • pain or tenderness around the eyes and cheekbones
  • sore throat
  • stuffy or runny nose
  • thick, white vaginal discharge with or without a mild odor
  • tightness of the chest
  • weight gain

Less common

  • Crying
  • depersonalization
  • false or unusual sense of well-being
  • hoarseness
  • mental depression
  • paranoia
  • quick to react or overreact emotionally
  • rapidly changing moods, mild feeling of sadness or discouragement that come and go

Incidence not known

  • Absent, missed, or irregular menstrual periods
  • bloody vaginal discharge
  • brown, blotchy spots on exposed skin
  • chills
  • clay-colored stools
  • contact lens intolerance
  • dark urine
  • decreased amount or quality of milk
  • dry mouth
  • dry skin
  • fruit-like or unpleasant breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • loss of appetite
  • medium to heavy, irregular vaginal bleeding between regular monthly periods, which may require the use of a pad or a tampon
  • rash
  • soreness, swelling, or discharge from the breast or breasts
  • trouble getting pregnant
  • unexplained weight loss
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to ethinyl estradiol / etonogestrel: vaginal ring


Adverse reactions leading to study discontinuation occurred in 13% of the women during clinical trials. The most common adverse reactions leading to discontinuation were device-related events (2.7%), mood changes (1.7%), headache/migraine (1.5%), and vaginal symptoms (1.2%).


Very common (10% or more): Vaginitis (13.8%)

Common (1% to 10%): Vaginal discharge, vaginal discomfort, breast pain/discomfort/tenderness, dysmenorrhea, genital pruritus, vaginal discomfort, pelvic pain, leucorrhoea, vaginal infection

Uncommon (0.1% to 1%): Dysuria, micturition urgency, pollakiuria, urinary tract infection, amenorrhea, breast enlargement, breast mass, cervical polyp, cervicitis, coital bleeding, coital discomfort, dyspareunia, ectropion of cervix, fibrocystic breast disease, menorrhagia, metrorrhagia, pelvic discomfort, premenstrual syndrome, uterine spasm, vaginal burning sensation, vaginal odor, vaginal pain, vulvovaginal discomfort, vulvovaginal dryness

Frequency not reported: Penile disorder, galactorrhea, uterine bleeding irregular

Postmarketing reports: Local reaction to penis, vaginal injury (including associated pain, discomfort, and bleeding) associated with ring breakage


In studies that were required or sponsored by regulatory agencies, this combined hormonal combination vaginal ring showed a VTE risk similar to combined oral contraceptive use (8.3 per 10,000 women-years versus 9.2 per 10,000 women-years).

Uncommon (0.1% to 1%): Blood pressure increased, hot flush

Rare (less than 0.1%): Venous thromboembolism, arterial thromboembolism

Frequency not reported: Deep vein thrombosis

Postmarketing reports: Arterial event, myocardial infarction, varicose vein aggravated


Frequency not reported: Anaphylaxis, angioedema


Common (1% to 10%): Medical device discomfort, discomfort/foreign body sensation


Common (1% to 10%): Nausea/vomiting, abdominal pain, diarrhea, toothache

Uncommon (0.1% to 1%): Abdominal distention, constipation, abdomen enlarged


Uncommon (0.1% to 1%): Breast fibroadenosis

Frequency not reported: Hormone dependent tumors, liver tumor


Common (1% to 10%): Bronchitis, coughing, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection


Common (1% to 10%): Acne

Uncommon (0.1% to 1%): Pruritus, rash, alopecia, eczema

Frequency not reported: Urticaria, chloasma

Postmarketing reports: Angioedema


Frequency not reported: Cholelithiasis, liver disease


Uncommon (0.1% to 1%): Visual disturbance


Common (1% to 10%): Allergic reaction

Frequency not reported: Hypersensitivity

Postmarketing reports: Anaphylaxis


Common (1% to 10%): Back pain

Uncommon (0.1% to 1%): Muscle spasm, pain in extremity


Uncommon (0.1% to 1%): Appetite increased


Common (1% to 10%): Mood changed/altered, depression, mood swings, affect lability, libido decreased

Uncommon (0.1% to 1%): Anxiety, irritability


Common (1% to 10%): Expulsion of contraceptive device, device-related event, weight increased, fatigue, fever, influenza-like symptoms

Uncommon (0.1% to 1%): Device breakage, device complication, cervicitis, herpes simplex, malaise, edema

Nervous system

Very common (10% or more): Headache/migraine (11.2%)

Uncommon (0.1% to 1%): Dizziness, hypoesthesia

Postmarketing reports: Stroke/cerebrovascular accident


Uncommon (0.1% to 1%): Cystitis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Nuvaring (www.drugs.com/nuvaring.html).

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Does this work with insurance plans, like Medicare?

No, you must decide at the pharmacy either to use your free pharmacy coupon or your insurance. 

What company produces Nuvaring?

Nuvaring is produced by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. Merck & Co., Inc. is an American pharmaceutical company based out of New Jersey. Their website is intended for us only my residents of the United States and Puerto Rico.

Nuvaring Prescription Savings Explained

FAQ Disclaimer: USA Rx LLC has a full endorsement of our prescription savings discount program. This product does not replace your insurance plan. You may check the price of both your insurance plan (copay) and our patient assistance program. That is an easy step to get the lowest price on your prescriptions. Our affiliates use the “powered by USA Rx” symbol in marketing materials. If you have a medical condition and need assistance with figuring out your best option is for a discount program of prescription savings, please give us a call or drop us an email. If you need medical help, please seek proper medical care as soon as possible. Chat with your doctor or pharmacist before using hormonal contraceptives with these types of female hormones to discuss about all possible side effects, including lack of vaginal moisture. Nuvaring contains estrogen and progestin and is part of a family of  hormonal contraceptives that affect your menstrual period. Nuvaring is an alternative to taking a birth control pill every day of the week, and most doctors recommend taking a one week break from using Nuvaring every month. If you get off schedule and remove your Nuvaring on the incorrect day of the week, contact your doctor. Contact a physician immediately if you experience difficulty breathing or believe you are at risk of HIV infection. All cardholders adhere to our privacy policy and we use recent information to create our pricing estimates, which are subject to change by Merck & Co., Inc. Prescription prices are subject to change.