Loading

Please wait...

Nucala

Generic Name: mepolizumab (MEP oh LIZ ue mab)
Brand Names: Nucala
Nucala (mepolizumab) is used to treat severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis. Includes Nucala side effects, interactions and indications.
  • Prescription Settings
  • X
  • Local Pharmacy Pickup available at . Pick up your medication at any of our participating pharmacies.
  • Mail Order Home Delivery available at , the easiest way to receive your medications.
  • Learn more

Nucala Coupons & Prices

Set your location
for drug prices near you

Enter your zip code

Please wait while the prices are loaded...
Click here to try again.

Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Drug Information:
Nucala (mepolizumab) is a monoclonal antibody that affects the actions of the body's immune system. Mepolizumab works by reducing levels of a certain type of white blood cell that may contrIbute to certain disorders. Nucala is a subcutaneous injection given every four weeks that is used together with other medicines to help control severe asthma in adults and children who are at least 6 years old. Nucala is also used in adults to help control symptoms and reduce flares of a rare autoimmune disorder called eosinophilic granulomatosis with polyangiitis (EPGA). Learn more

Pickup / Home Delivery

USARx offers multiple ways to purchase this medication. Choose the Best option for you!

  • Guaranteed Price
    Local Pharmacy Pickup

    Pay this amount and pick up your prescription at ANY Retail pharmacy of your choice! Walgreens, CVS, Walmart, etc.

  • 30-day supply
    90-day supply
    Mail Order Home Delivery

    The easiest way to receive your medications.

Nucala Side Effects

Note: This document contains side effect information about mepolizumab. Some of the dosage forms listed on this page may not apply to the brand name Nucala.

In Summary

More frequent side effects include: injection site reaction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to mepolizumab: subcutaneous powder for solution

Along with its needed effects, mepolizumab (the active ingredient contained in Nucala) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking mepolizumab:

Incidence not known

  • Blurred vision
  • confusion
  • cough
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • hives or welts, itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • painful blisters on the trunk of the body
  • redness of the skin
  • sweating
  • tightness in the chest
  • unusual tiredness or weakness

Some side effects of mepolizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • headache

Less common

  • Back pain
  • bladder pain
  • bloody or cloudy urine
  • chills
  • cough
  • diarrhea
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches, pains, or spasms
  • nausea
  • runny nose
  • shivering
  • skin rash, encrusted, scaly, and oozing
  • sore throat
  • sweating
  • trouble sleeping
  • upper abdominal or stomach pain
  • vomiting

For Healthcare Professionals

Applies to mepolizumab: subcutaneous powder for injection, subcutaneous solution

General

The more commonly reported side effects were headache, injection site reactions, and back pain.

Nervous system

Dizziness occurred in at least 3% of patients treated with this drug in a controlled, long-term clinical study.

Very common (10% or more): Headache (up to 19%)

Frequency not reported: Dizziness

Hypersensitivity

Common (1% to 10%): Systemic non-allergic/administration-related reactions (including rash, flushing, myalgia), systemic/hypersensitivity reactions (including rash, pruritus, headache, myalgia)

Frequency not reported: Allergic rhinitis, angioedema, urticaria

Many systemic reactions occurred on the day of dosing. Systemic reactions occurred in 10% of patients treated with this drug compared to 7% of placebo-treated patients. Non-allergic reactions occurred in 2% of patients given this drug versus 3% of patients with placebo; allergic systemic reactions occurred in 1% and 2% of patients given this drug or placebo, respectively.

Allergic rhinitis occurred in at least 3% of patients treated with this drug in a controlled, long-term clinical study.

Local

Common (1% to 10%): Injection site reactions (e.g., pain, swelling, erythema, itching, burning)

Injection site reactions occurred in 8% and 3% of patients given this drug or placebo, respectively. The reactions more commonly occurred within the first 3 injections, with a decrease in frequency on subsequent injections.

Immunologic

In a clinical trial, 6% of patients developed anti-mepolizumab (the active ingredient contained in Nucala) antibodies; these antibodies were shown to slightly increase drug clearance, but the clinical relevance is unknown.

Viral infection occurred in at least 3% of patients treated with this drug in a controlled, long-term clinical study.

Common (1% to 10%): Influenza, anti-mepolizumab antibody formation

Frequency not reported: Viral infection

Dermatologic

Common (1% to 10%): Pruritus, eczema

Frequency not reported: Rash, flushing, herpes zoster reaction

Rash and herpes zoster occurred in at least 3% of patients treated with this drug in a controlled, long-term clinical study.

Musculoskeletal

Common (1% to 10%): Back pain, muscle spasms

Frequency not reported: Musculoskeletal pain, myalgia

Musculoskeletal pain occurred in at least 3% of patients treated with this drug in a controlled, long-term clinical study.

Gastrointestinal

Gastroenteritis, abdominal pain, nausea, toothache, and vomiting occurred in at least 3% of patients treated with this drug in a controlled, long-term clinical study.

Common (1% to 10%): Upper abdominal pain

Frequency not reported: Gastroenteritis, abdominal pain, nausea, toothache, vomiting

Other

Common (1% to 10%): Fatigue, pyrexia

Frequency not reported: Asthenia, ear infection

Asthenia, ear infection, and pyrexia occurred in at least 3% of patients treated with this drug in a controlled, long-term clinical study.

Genitourinary

Common (1% to 10%): Urinary tract infection

Respiratory

Bronchitis, dyspnea, lower respiratory tract infection, nasal congestion, nasopharyngitis, pharyngitis, and viral respiratory tract infection occurred in at least 3% of patients treated with this drug in a controlled, long-term clinical study.

Common (1% to 10%): Lower respiratory tract infection, pharyngitis, nasal congestion

Frequency not reported: Bronchitis, dyspnea, nasopharyngitis, viral respiratory tract infection, bronchospasm

Cardiovascular

Frequency not reported: Hypotension

Renal

Frequency not reported: Cystitis

Cystitis occurred in at least 3% of patients treated with this drug in a controlled, long-term clinical study.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Nucala (www.drugs.com/nucala.html).