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Novolin 70/30

Generic Name: insulin isophane and insulin regular (IN su lin EYE soe fane and IN su lin REG ue lar)
Brand Name: HumuLIN 70/30, HumuLIN 70/30 KwikPen, NovoLIN 70/30, ReliOn/NovoLIN 70/30
Physician reviewed Novolin 70/30 patient information - includes Novolin 70/30 description, dosage and directions.
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Drug Information:
Insulin is a hormone that works by lowering levels of Glucose (sugar) in the blood. Insulin isophane is a intermediate-acting insulin. Insulin regular is an short-acting insulin. This combination insulin starts to work within 10 to 20 minutes after injection, peaks in 2 hours, and keeps working for up to 24 hours. Novolin 70/30 is a combination medicine used to improve blood sugar control in adults with diabetes mellitus. Novolin 70/30 may also be used for purposes not listed in this medication guide. Learn more

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Novolin 70/30 Side Effects

Note: This document contains side effect information about insulin isophane / insulin regular. Some of the dosage forms listed on this page may not apply to the brand name Novolin 70 / 30.

For the Consumer

Applies to insulin isophane/insulin regular: subcutaneous suspension, subcutaneous suspension pen-injector

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
  • Very bad irritation where the shot was given.
  • Anxiety.
  • Change in eyesight.
  • Chills.
  • Very bad dizziness or passing out.
  • Mood changes.
  • Seizures.
  • Slurred speech.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Change in skin to thick or thin where the shot was given.
  • Low blood sugar may occur. Signs may be dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating. Call the doctor right away if any of these signs occur. Follow what you have been told to do if low blood sugar occurs. This may include taking glucose tablets, liquid glucose, or some fruit juices.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Weight gain.
  • Irritation where the shot is given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to insulin isophane/insulin regular: subcutaneous suspension

General

Adverse reactions observed with insulin therapy include hypoglycemia, allergic reactions, local injection site reactions, lipodystrophy, rash, pruritus, weight gain, and edema.

Hypersensitivity

Hypersensitivity side effects have included both local and systemic reactions. Local reactions have presented as erythema, swelling, heat, or subcutaneous nodules. They usually occurred within the first two weeks of therapy and then disappear. Systemic allergy is a generalized allergy to insulin which may present as a rash over the whole body, shortness of breath, wheezing, drop in blood pressure, fast pulse, or sweating. Severe cases may be life-threatening.

There have been rare reports of patients with hypersensitivity reactions to human insulins who have tolerated insulins of animal origin.

Uncommon (0.1% to 1%): Local reactions such as redness, swelling, or itching at the injection site

Very rare (less than 0.01%): Systemic reactions

Cardiovascular

Frequency not reported: Peripheral edema

Insulin may cause sodium retention and edema, especially if previously poor metabolic control is improved by intensified insulin therapy.

Dermatologic

Uncommon (0.1% to 1%): Lipodystrophy

Frequency not reported: Rash, pruritus

Metabolic

Very common (10% or more): Hypoglycemia

Ocular

Refraction anomalies may occur upon initiation of insulin; symptoms are usually transient. Intensification of insulin therapy may be associated with temporary worsening of diabetic retinopathy.

Frequency not reported: Refraction anomalies, temporary worsening of diabetic retinopathy

Local

Injection site reactions including pain, redness, hives, inflammation, bruising, swelling, and itching, may occur. These reactions are usually transitory and may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique.

Frequency not reported: Injection site reactions

Other

Frequency not reported: Weight gain

Weight gain has been attributed to the anabolic effects of insulin and the decrease in glycosuria.

Immunologic

Frequency not reported: Anti-insulin antibodies

Nervous system

Frequency not reported: Acute painful neuropathy

Fast improvement in blood glucose has been associated with acute painful neuropathy, which is generally reversible.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Novolin 70/30 (www.drugs.com/mtm/novolin-70-30.html).