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Nortriptyline is a tricyclic antidepressant. It affects chemicals in the brain that may be unbalanced in people with depression.
Nortriptyline is used to treat symptoms of depression.
Nortriptyline may also be used for purposes not listed in this medication guide.
You should not use nortriptyline if you have recently had a heart attack, or if you are allergic to certain medicines.
Do not use this medicine if you have used a MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine or have receieved a methylene blue injection.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using nortriptyline. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
You should not use nortriptyline if you are allergic to it, or if:
you have recently had a heart attack;
you are allergic to similar antidepressants (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, protriptyline, trimipramine); or
you are allergic to certain seizure medications (carbamazepine, eslicarbazepine, oxcarbazepine, rufinamide).
Do not use nortriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine, as well as methylene blue injection.
To make sure nortriptyline is safe for you, tell your doctor if you have:
heart disease, or a history of heart attack, stroke, or seizures;
bipolar disorder (manic-depression);
schizophrenia or other mental illness;
liver disease;
a thyroid disorder;
diabetes (nortriptyline may raise or lower blood sugar);
narrow-angle glaucoma; or
problems with urination.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using nortriptyline. Your family or other caregivers should also be alert to changes in your mood or symptoms.
It is not known whether nortriptyline will affect an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether nortriptyline passes into breast milk or if it could affect a nursing baby. Tell your doctor if you are breast-feeding a baby.
Do not give this medicine to a child without medical advice. Nortriptyline is not approved for use in children.
Take nortriptyline exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
If you need surgery, tell the surgeon ahead of time that you are using nortriptyline. You may need to stop using the medicine for a short time.
Do not stop using nortriptyline suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
It may take a few weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of nortriptyline can be fatal.
Signs and symptoms of an overdose may include chest pain, dizziness, fainting, seizures, difficulty breathing, confusion, hallucinations, restlessness, drowsiness, vomiting, or fevers.
Do not drink alcohol. Nortriptyline can increase the effects of alcohol, which could be dangerous.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid exposure to sunlight or tanning beds. Nortriptyline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Get emergency medical help if you have signs of an allergic reaction to nortriptyline: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
restless muscle movements in your eyes, tongue, jaw, or neck;
a light-headed feeling, like you might pass out;
seizure (convulsions);
new or worsening chest pain, pounding heartbeats or fluttering in your chest;
sudden numbness or weakness, problems with vision, speech, or balance;
fever, sore throat, easy bruising, unusual bleeding;
jaundice (yellowing of the skin or eyes);
painful or difficult urination; or
high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.
Older adults may be more likely to have side effects from this medication.
Common nortriptyline side effects may include:
nausea, vomiting, loss of appetite;
anxiety, sleep problems (insomnia);
dry mouth, unusual taste;
constipation;
vision changes;
breast swelling (in men or women); or
decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking nortriptyline with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Many medications used to treat urinary incontinence, glaucoma, or nausea also interact with nortriptyline. Tell your doctor about any medication you are taking.
Before taking nortriptyline, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, or sertraline. You must wait at least 5 weeks after stopping fluoxetine (Prozac) before you can take this medicine.
Other drugs can interact with nortriptyline, which may cause unwanted or dangerous effects. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with nortriptyline. Give a list of all your medicines to any healthcare provider who treats you.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use nortriptyline only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Nortriptyline Hcl (www.drugs.com/nortriptyline.html).
Applies to nortriptyline: oral capsule, oral solution
Oral route (Capsule; Solution)
Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder and other psychiatric disorders. This risk must be balanced with the clinical need, as nortriptyline is not approved for use in pediatric patients. Closely monitor patients of all ages for clinical worsening, suicidality, or unusual changes in behavior; not approved for use in pediatric patients.
Along with its needed effects, nortriptyline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking nortriptyline:
Incidence not known
Some side effects of nortriptyline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to nortriptyline: compounding powder, oral capsule, oral solution
Frequency not reported: Alteration in electroencephalogram (EEG) patterns, ataxia, dizziness, drowsiness, extrapyramidal symptoms, extremity paresthesia, headache, incoordination, mydriasis, numbness, peculiar taste, peripheral neuropathy, seizures, stroke, tingling, tremors
Frequency not reported: Agitation, anxiety, confusional states with hallucinations, delusions, disorientation, exacerbation of psychosis, hypomania, increased/decreased libido, insomnia, nightmares, panic, restlessness, suicidal behaviors, suicidal ideation
Frequency not reported: Abdominal cramps, black tongue, constipation, diarrhea, dry mouth, epigastric distress, gingivitis, nausea, paralytic ileus, parotid swelling, stomatitis, sublingual adenitis, tongue edema, vomiting
Frequency not reported: Arrhythmias, edema, flushing, general edema, heart block, hypertension, hypotension, myocardial infarction, palpitation, tachycardia
Postmarketing reports: Brugada syndrome
Frequency not reported: Breast enlargement, delayed micturition, dilation of the urinary tract, galactorrhea, impotence, nocturia, urinary frequency, urinary retention, testicular swelling
Frequency not reported: Alopecia, face edema, itching, perspiration, petechia, photosensitization, skin rash, urticaria
Frequency not reported: Agranulocytosis, aplastic anemia, bone marrow depression, eosinophilia, purpura, thrombocytopenia
Frequency not reported: Drug fever, fatigue, malaise, tinnitus, weakness
Frequency not reported: Altered liver function, hepatitis, jaundice (simulating obstructive), liver necrosis
Frequency not reported: Anorexia, elevation/depression of blood sugar levels, weight gain/loss
Frequency not reported: Blurred vision, disturbance of accommodation
Postmarketing reports: Angle-closure glaucoma
Frequency not reported: Gynecomastia, syndrome of inappropriate antidiuretic hormone (SIADH) secretion
Frequency not reported: Cross sensitivity (with other tricyclic drugs)
Frequency not reported: Increased risk of bone fractures
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Nortriptyline Hcl (www.drugs.com/nortriptyline.html).
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