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Nipent

Generic Name: pentostatin (PEN toe stah tin)
Brand Name: Nipent
Physician reviewed Nipent patient information - includes Nipent description, dosage and directions.
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Drug Information:
Nipent is used to treat hairy cell leukemia (a type of blood cancer). Nipent may also be used for purposes not listed in this medication guide. Nipent can cause harmful side effects on your kidneys, liver, lungs, or central nervous system. Call your doctor at once if you have symptoms such as: swelling, rapid weight gain, little or no urinating, pink or red urine, severe shortness of breath, wheezing, chest pain, cough, vision problems, numbness, tingling, or burning pain. You should not use Nipent if you are allergic to it. Learn more

Nipent Side Effects

Nipent Side Effects

Note: This document contains side effect information about pentostatin. Some of the dosage forms listed on this page may not apply to the brand name Nipent.

In Summary

Common side effects of Nipent include: skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pentostatin: intravenous powder for solution

Warning

Intravenous route (Powder for Solution)

Pentostatin should be administered under the supervision of a physician qualified and experienced in the use of cancer chemotherapeutic agents. The use of doses higher than those specified is not recommended. Dose-limiting severe renal, liver, pulmonary, and CNS toxicities occurred in Phase 1 studies that used pentostatin at higher doses (20 to 50 mg/m(2) in divided doses over 5 days) than recommended. In a clinical investigation in patients with refractory chronic lymphocytic leukemia using pentostatin at the recommended dose in combination with fludarabine phosphate, 4 of 6 patients entered in the study had severe or fatal pulmonary toxicity. The use of pentostatin in combination with fludarabine phosphate is not recommended.

Along with its needed effects, pentostatin (the active ingredient contained in Nipent) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Along with its needed effects, pentostatin may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur while taking pentostatin:

More common

  • Cough or hoarseness
  • fever or chills
  • lower back or side pain
  • pain
  • painful or difficult urination
  • skin rash or itching (sudden)
  • unusual tiredness or weakness

Less common

  • Anxiety or nervousness
  • black, tarry stools
  • blood in the urine or stools
  • changes in vision
  • chest pain
  • confusion
  • cramps in lower legs
  • mental depression
  • nosebleed
  • numbness or tingling of the hands or feet
  • pinpoint red spots on the skin
  • shortness of breath
  • sleepiness
  • sore, red eyes
  • sores in the mouth or on the lips
  • stomach pain
  • swelling of the feet or lower legs
  • trouble with sleeping
  • unusual bleeding or bruising

Some side effects of pentostatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • headache
  • loss of appetite
  • muscle pain
  • nausea and vomiting
  • skin rash

Less common

  • Back pain
  • bloating or gas
  • constipation
  • dry skin
  • general feeling of discomfort or illness
  • itching
  • joint pain
  • weakness
  • weight loss

For Healthcare Professionals

Applies to pentostatin: intravenous powder for injection

Hematologic

Very common (10% or more): Leukopenia (22%), thrombocytopenia, anemia, blood disorder, eosinophilia, hypochromic pancytopenia

Common (1% to 10%): Agranulocytosis, acute leukemia, febrile neutropenia, ecchymosis, lymphadenopathy, splenomegaly, hemorrhage, agranulocytosis

Uncommon (0.1% to 1%): Pure red cell aplasia, autoimmune hemolytic anemia, anemia-hemolytic, aplastic anemia hemolytic uremic syndrome, idiopathic thrombocytopenia purpura, thrombotic thrombocytopenia purpura

Rare (less than 0.1%): Autoimmune thrombocytopenia

Gastrointestinal

Very common (10% or more): Nausea/vomiting (63%), diarrhea (17%), abdominal pain (16%), stomatitis (12%)

Common (1% to 10%): Oral candidiasis, perianal abscess, dental abnormalities, dyspepsia, flatulence, gingivitis

Uncommon (0.1% to 1%): Acute gastroenteritis

Rare (less than 0.1%): Esophageal candidiasis

Frequency not reported: Constipation, dysphagia, glossitis, ileus

Dermatologic

Very common (10% or more): Rash (43%), pruritus (21%)

Common (1% to 10%): Furunculosis, abscess skin, mycotic skin infection, sweating, skin disorder, face edema, dry skin urticaria

Hepatic

Common (1% to 10%): Hepatic disorder, elevated liver function tests

Frequency not reported: Kidney function abnormal, nephropathy

Genitourinary

Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Cystitis

Frequency not reported: Amenorrhea, breast lump, impotence

Respiratory

Very common (10% or more): Cough (20%), upper respiratory infection (13%), rhinitis (11%), dyspnea (11%), pharyngitis

Common (1% to 10%): Sinusitis, pneumonia, bronchitis, E. coli pneumonia, fungal pneumonia, asthma

Uncommon (0.1% to 1%): Pulmonary aspergillosis, pulmonary aspergillosis

Frequency not reported: Bronchospasm, larynx edema

Nervous system

Very common (10% or more): Headache (17%)

Common (1% to 10%): Dizziness, paresthesia

Frequency not reported: Amnesia, ataxia, convulsions, dysarthria, encephalitis, hyperkinesia, meningism, neuralgia, neuritis, neuropathy, paralysis, syncope, twitching, vertigo

Cardiovascular

Common (1% to 10%): Chest pain, hypotension

Frequency not reported: Angina pectoris, arrhythmia, A-V block, bradycardia, extrasystoles ventricular, heart arrest, heart failure, hypertension, pericardial effusion, phlebitis, pulmonary embolus, sinus arrest, tachycardia, thrombophlebitis deep, vasculitis

Hypersensitivity

Common (1% to 10%): Allergic reaction

Rare (0.01% to 0.1%): Anaphylaxis

Ocular

Common (1% to 10%): Conjunctivitis

Frequency not reported: Amblyopia, dry eyes, labyrinthitis, lacrimation disorder, nonreactive eye, photophobia, retinopathy, abnormal vision, watery eyes

Musculoskeletal

Very common (10% or more): Myalgia (19%)

Common (1% to 10%): Osteomyelitis, arthralgia

Frequency not reported: Arthritis, gout

Metabolic

Very common (10% or more): Anorexia (13%)

Common (1% to 10%): Neurologic disorder, CNS/CNS toxicity

Frequency not reported: Hypercalcemia, hyponatremia

Immunologic

Very common (10% or more): Viral infection

Common (1% to 10%): (Herpes zoster, infection unspecified), cellulitis, bacterial infection, herpes simplex, sepsis, septic shock, staphylococcal infection, Graft versus host disease

Uncommon (0.1% to 1%): Clostridium difficile colitis, cytomegalovirus infection, graft failure

Frequency not reported: Influenza-like symptoms

Psychiatric

Common (1% to 10%): Confusion, insomnia, somnolence, anxiety, depression, nervousness

Frequency not reported: decrease/loss libido, emotional lability, hallucination, hostility, neurosis, thinking abnormal, dreaming abnormal

Oncologic

Common (1% to 10%): Neoplasms, skin carcinoma

Uncommon (0.1% to 1%): Tumor lysis syndrome

Frequency not reported: Acute leukemia, hemolytic anemia, aplastic anemia

Other

Very common (10% or more): Fever (46%), fatigue (42%), chills (19%), asthenia (12%)

Common (1% to 10%): Pain, peripheral edema

Frequency not reported: Hangover effect, deafness, earache, tinnitus, unusual taste

Renal

Common (1% to 10%): Urosepsis, elevated creatinine

Frequency not reported: Renal failure, renal insufficiency, renal stone

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Nipent (www.drugs.com/mtm/nipent.html).