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Neulasta Prescription
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Generic Name: pegfilgrastim (PEG fil GRAS tim)
Brand Names: Neulasta
Neulasta (pegfilgrastim) is used to treat neutropenia, a lack of certain white blood cells caused by cancer chemotherapy. Includes Neulasta side effects, interactions and indications.
Generic Name: pegfilgrastim (PEG fil GRAS tim)
Brand Names: Neulasta
Neulasta (pegfilgrastim) is used to treat neutropenia, a lack of certain white blood cells caused by cancer chemotherapy. Includes Neulasta side effects, interactions and indications.
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1 tablets of Neulasta 40 mg
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Neulasta Drug Information:

Neulasta (pegfilgrastim) is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection. Neulasta injection is a prescription medicine used to prevent neutropenia, a lack of certain white blood cells caused by receiving chemotherapy. Neulasta may also be used for purposes not listed in this medication guide. Before using Neulasta, tell your doctor if you have sickle cell disorder, chronic myeloid leukemia, myelodysplasia (also called "preleukemia"), or if you are allergic to latex. Learn more

Neulasta Side Effects

Note: This document contains side effect information about pegfilgrastim. Some of the dosage forms listed on this page may not apply to the brand name Neulasta.

In Summary

Common side effects of Neulasta include: ostealgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pegfilgrastim: subcutaneous solution

Along with its needed effects, pegfilgrastim (the active ingredient contained in Neulasta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pegfilgrastim:

More common

  • Chills
  • cough
  • fever
  • sore throat
  • ulcers, sores, or white spots in the mouth


  • Bluish lips or skin
  • pain, left upper abdomen or shoulder
  • tightness in the chest
  • troubled breathing

Incidence not known

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blisters in the skin
  • blood in the urine
  • cloudy urine
  • decrease in how much or how often you urinate
  • difficulty with swallowing
  • dizziness
  • fainting or lightheadedness
  • fast heartbeat
  • flushing or redness of the skin
  • hives or welts, skin rash
  • itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea
  • sores on the skin
  • stomach pain
  • swelling of the hands, ankles, feet, or lower legs
  • unusual tiredness or weakness
  • unusually warm skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking pegfilgrastim:

Symptoms of overdose

  • Bone pain
  • chest pain
  • difficult or labored breathing
  • eye pain
  • general feeling of illness
  • headache

Some side effects of pegfilgrastim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • change in sense of taste
  • constipation
  • cracked lips
  • diarrhea
  • hair loss or thinning of the hair
  • heartburn
  • indigestion
  • joint pain
  • lack or loss of strength
  • loss of appetite
  • muscle soreness
  • swelling or inflammation of the mouth
  • trouble sleeping
  • vomiting
  • weakness, generalized
  • weight loss

Incidence not known

  • Body produces substance that can bind to drug making it less effective or cause side effects

For Healthcare Professionals

Applies to pegfilgrastim: subcutaneous solution


The most commonly reported side effects included bone pain, skeletal pain, medullary bone pain, and spontaneously reversible mild to moderate lactate dehydrogenase elevations.


Very common (10% or more): Bone pain (up to 31%), skeletal pain (up to 27%), medullary bone pain (up to 26%)

Common (1% to 10%): Arthralgia, back pain, extremity pain, limb pain, musculoskeletal pain, myalgia, neck pain, polyarthralgia, polymyalgia


Very common (10% or more): Spontaneously reversible mild to moderate lactate dehydrogenase elevations (up to 18%), spontaneously reversible mild to moderate alkaline phosphatase elevations (up to 11%), spontaneously reversible mild to moderate uric acid elevations (up to 11%)

Common (1% to 10%): Spontaneously reversible severe uric acid elevations

Frequency not reported: Anorexia


Common (1% to 10%): Fever, non-cardiac chest pain, pain, pyrexia

Frequency not reported: Fatigue, generalized weakness, mucositis


Common (1% to 10%): Alopecia, contact dermatitis

Uncommon (0.1% to 1%): Acute febrile dermatosis, cutaneous vasculitis, erythema/generalized erythema, pruritus, skin rash, Sweet's syndrome, urticaria


Common (1% to 10%): Leukocytosis, thrombocytopenia

Uncommon (0.1% to 1%): Asymptomatic splenomegaly, fatal splenic rupture, sickle cell crisis, splenic rupture, splenomegaly/enlarged spleen

Frequency not reported: Granulocytopenia, neutropenic fever


Common (1% to 10%): Application site reactions, injection site pain

Uncommon (0.1% to 1%): Injection site erythema, injection site reactions

Postmarketing reports: Application site bruise, application site discomfort, application site hemorrhage, local skin reactions


Common (1 to 10%): Diarrhea, nausea

Frequency not reported: Abdominal pain, constipation, dyspepsia, stomatitis, vomiting


Common (1% to 10%): Influenza, preexisting binding antibodies


Common (1% to 10%): Chest pain

Uncommon (0.1% to 1%): Capillary leak syndrome, flushing, hypotension

Rare (0.01% to 0.1%): Aortitis

Frequency not reported: Peripheral edema

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Dizziness, taste perversion


Common (1% to 10%): Periorbital edema


Uncommon (0.1% to 1%): Acute respiratory distress syndrome (ARDS), dyspnea, fatal ARDS, interstitial pneumonia, pulmonary adverse reactions, pulmonary edema, pulmonary fibrosis, pulmonary infiltrates, respiratory failure


Uncommon (0.1% to 1%): Anaphylaxis, angioedema, hypersensitivity reactions/hypersensitivity-type reactions, serious allergic reactions

Frequency not reported: Allergies to acrylics

Postmarketing reports: Allergic reactions, allergic-type reactions, anaphylactic reactions


Uncommon (0.1% to 1%): Transient elevations in ALT, transient elevations in AST, transient elevations in liver function tests


Uncommon (0.1% to 1%): Glomerulonephritis


Frequency not reported: Potential for tumor growth stimulatory effects on malignant cells


Frequency not reported: Insomnia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Neulasta (www.drugs.com/neulasta.html).