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Nesina

Generic Name: alogliptin (AL oh GLIP tin)
Brand Names: Nesina
Nesina (alogliptin) is an oral diabetes medicine used to treat type 2 diabetes. Includes Nesina side effects, interactions and indications.
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Drug Information:
Nesina (alogliptin) is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. Nesina is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes. Nesina is sometimes used in combination with other diabetes medications. Nesina can cause serious side effects on your heart or pancreas, especially if you have ever had similar problems, or if you have kidney or liver disease. Learn more

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Nesina Side Effects

Note: This document contains side effect information about alogliptin. Some of the dosage forms listed on this page may not apply to the brand name Nesina.

In Summary

More frequent side effects include: upper respiratory tract infection, headache, and nasopharyngitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to alogliptin: oral tablet

Along with its needed effects, alogliptin (the active ingredient contained in Nesina) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alogliptin:

More common

  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • dizziness
  • fast heartbeat
  • headache
  • increased hunger
  • nausea
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness

Less common

  • Chest pain
  • decreased urine output
  • dilated neck veins
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • swelling of the face, fingers, feet, or lower legs
  • tightness in chest
  • troubled breathing
  • weight gain

Rare

  • Blistering, peeling, or loosening of the skin
  • bloating
  • constipation
  • cough
  • dark-colored urine
  • diarrhea
  • difficulty with swallowing
  • feeling of discomfort
  • fever
  • general feeling of tiredness or weakness
  • headache
  • hives, itching, or rash
  • indigestion
  • inflammation of the joints
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • muscle aches
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach pain, continuing
  • swollen lymph glands
  • tightness in the chest
  • vomiting
  • yellow eyes or skin

Incidence not known

  • Redness of the skin
  • severe joint pain

Some side effects of alogliptin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Body aches or pain
  • ear congestion
  • loss of voice
  • sneezing
  • stuffy or runny nose

For Healthcare Professionals

Applies to alogliptin: oral tablet

General

The most frequently reported side effects included nasopharyngitis, headache, and upper respiratory tract infection.

Gastrointestinal

Common (1% to 10%): Abdominal pain, gastroesophageal reflux disease

Uncommon (0.1% to 1%): Pancreatitis

Postmarketing reports: Acute pancreatitis, diarrhea, constipation, nausea, ileus

During clinical trials, acute pancreatitis was reported in 6 (0.2%) patients receiving 25 mg and 2 patients (less than 0.1%) who were treated with active comparators or placebo. In a cardiovascular outcome trial of patient with high cardiovascular risk, acute pancreatitis was reported in 10 patients receiving this drug and 7 patients receiving placebo (0.4% vs 0.3%).

Musculoskeletal

Frequency not reported: Arthralgia

Between October 2006 and December 2013, thirty-three cases of severe arthralgia have been reported to the FDA Adverse Event Reporting System Database. Each case involved the use of 1 or more dipeptidyl peptidase-4 (DPP-4) inhibitor. In all cases, substantial reduction in prior activity level was reported, 10 patients were hospitalized due to disabling joint pain. In 22 cases, symptoms appeared within 1 month of starting therapy, in 23 cases symptoms resolved less than 1 month after discontinuation. A positive rechallenge was reported in 8 cases, with 6 cases involving use of a different DPP-4 inhibitor. Sitagliptin had the greatest number of cases reported (n=28) followed by saxagliptin (n=5), linagliptin (n=2), alogliptin (n=1), and vildagliptin (n=2).

Hepatic

Postmarketing reports: Hepatic enzyme elevations, fulminant hepatic failure

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity reactions (0.6%)

Postmarketing reports: Anaphylaxis, angioedema, rash, urticaria, severe cutaneous adverse reactions (Stevens-Johnson syndrome)

Nervous system

Common (1% to 10%): Headache

Respiratory

Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection

Dermatologic

Postmarketing reports of bullous pemphigoid requiring hospitalization have been reported with dipeptidyl peptidase-4 (DPP-4) inhibitors use. These case typically recovered with topical or systemic immunosuppressive treatment and discontinuation of DPP-4 inhibitor.

Common (1% to 10%): Pruritus, rash

Postmarketing reports: Exfoliative skin conditions including Stevens-Johnson syndrome, erythema multiforme, angioedema, urticaria

Dipeptidyl peptidase-4 inhibitors:

Postmarketing reports: Bullous pemphigoid

Metabolic

Common (1% to 10%): Hypoglycemia

Based on a pooled analysis the hypoglycemic risk of this drug was considered neutral.

Cardiovascular

Frequency not reported: Heart failure

In a clinical trial in patients with recent acute coronary syndrome, a greater proportion of patients receiving this drug were hospitalized for congestive heart failure compared with placebo (3.9% [n=106] vs 3.3% [n=89]),

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Nesina (www.drugs.com/nesina.html).