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Nerlynx

Generic Name: neratinib (ne RA ti nib)
Brand Names: Nerlynx
Nerlynx (neratinib) is used for the extended adjuvant treatment of early-stage, HER2-positive breast cancer. Includes Nerlynx side effects, interactions and indications.
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Drug Information:
Nerlynx (neratinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Nerlynx is used to treat a certain type of early-stage breast cancer. It is used for this condition only if your tumor tests positive for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells. Nerlynx is usually given after you have been treated with another medicine called trastuzumab (Herceptin). Nerlynx can cause severe diarrhea, which can be life-threatening if it leads to dehydration. You may be given anti-diarrhea medications for the first 2 months of treatment with Nerlynx. Learn more

Nerlynx Side Effects

Nerlynx Side Effects

Note: This document contains side effect information about neratinib. Some of the dosage forms listed on this page may not apply to the brand name Nerlynx.

For the Consumer

Applies to neratinib: oral tablet

Along with its needed effects, neratinib (the active ingredient contained in Nerlynx) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking neratinib:

More common

  • Diarrhea

Less common

  • Confusion
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • increase in heart rate
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • thirst
  • unusual tiredness or weakness
  • wrinkled skin

Rare

  • Bloody urine
  • increased blood pressure
  • increased thirst
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • loss of appetite
  • lower back or side pain
  • nausea
  • raised, firm, bright red patches of skin on the arm or leg
  • stomach pain
  • swelling of the face, fingers, or lower legs
  • troubled breathing
  • vomiting
  • weight gain

Some side effects of neratinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • bladder pain
  • bloody nose
  • bloody or cloudy urine
  • decreased appetite
  • decreased weight
  • difficult, burning, or painful urination
  • discoloration of the fingernails or toenails
  • dry skin
  • frequent urge to urinate
  • heartburn
  • indigestion
  • muscle spasms
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth

Less common

  • Deep cracks, grooves, or lines in the skin
  • dry mouth

For Healthcare Professionals

Applies to neratinib: oral tablet

General

The most common adverse reactions (more than 5%) were diarrhea, nausea, abdominal pain, fatigue, vomiting, rash, stomatitis, decreased appetite, muscle spasms, dyspepsia, increased AST or ALT, nail disorder, dry skin, abdominal distention, decreased weight, and urinary tract infection.

Gastrointestinal

Very common (10% or more): Diarrhea (95%), nausea (43%), abdominal pain (36%), vomiting (26%), stomatitis (14%), dyspepsia (10%)

Common (1% to 10%): Abdominal distention, dry mouth

Other

Very common (10% or more): Fatigue (27%)

Dermatologic

Very common (10% or more): Rash (18%)

Common (1% to 10%): Nail disorder, rash, skin fissures

Metabolic

Very common (10% or more): Decreased appetite (12%)

Common (1% to 10%): Decreased weight, dehydration

Musculoskeletal

Very common (10% or more): Muscle spasms (11%)

Genitourinary

Common (1% to 10%): Urinary tract infection

Hepatic

Common (1% to 10%): Increased ALT, increased AST

Respiratory

Common (1% to 10%): Epistaxis

Cardiovascular

Frequency not reported: Hypotension

Renal

Frequency not reported: Renal failure

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Nerlynx (www.drugs.com/nerlynx.html).