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Nateglinide Prescription
Generic Name: nateglinide (oral) (na ta GLYE nide)
Brand Name: Starlix
Physician reviewed nateglinide (oral) patient information - includes nateglinide description, dosage and directions.
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Nateglinide Drug Information:

Nateglinide is used together with diet and exercise to improve blood sugar control in adults with type 2 Diabetes mellitus. nateglinide is not for treating type 1 Diabetes. Other Diabetes medicines are sometimes used in combination with nateglinide if needed. Nateglinide may also be used for purposes not listed in this medication guide. You should not use nateglinide if you have Diabetic ketoacidosis (call your doctor for treatment). You should not use nateglinide if you are allergic to it, or if you have: Learn more

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Nateglinide Side Effects

For the Consumer

Applies to nateglinide: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, nateglinide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nateglinide:

Less common

  • Convulsions (seizures)
  • unconsciousness

Check with your doctor as soon as possible if any of the following side effects occur while taking nateglinide:

Less common

  • Low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness

Incidence not known-occurred during clinical practice

  • Hives or welts
  • itching
  • redness of skin
  • skin rash
Side effects not requiring immediate medical attention

Some side effects of nateglinide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Cough
  • runny or stuffy nose
  • sore throat

Less common

  • Abdominal or stomach pain
  • back pain
  • chills
  • dizziness
  • pain in joints or muscles
  • sneezing
  • swelling in joints

For Healthcare Professionals

Applies to nateglinide: oral tablet


The most frequently reported adverse events included upper respiratory tract infections and symptoms of hypoglycemia.


Common (1% to 10%): Hypoglycemia

Frequency not reported: Increases in mean uric acid level

Hypoglycemia has been reported and has generally been mild and corrected by intake of carbohydrates. In comparative clinical trials, hypoglycemia was reported in 10.4%, 14.5%, 6.9%, 19.8%, and 4.1% in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, and placebo, respectively.

Mean uric acid levels were increased in patient receiving this drug as monotherapy. The difference from placebo in treated patients was 0.29 mg/dL, 0.45 mg/dL, 0.28 mg/dL, and 0.19 mg/dL in patients receiving nateglinide alone, nateglinide plus metformin, metformin alone, glyburide alone, respectively. The clinical significance of these findings is unknown.


Common (1% to 10%): Upper respiratory tract infection, bronchitis, coughing


Postmarketing reports: Hypersensitivity reactions such as rash, itching, and urticaria


Common (1% to 10%): Diarrhea, abdominal pain, dyspepsia, nausea

Uncommon (0.1% to 1%): Vomiting

Gastrointestinal symptoms, especially diarrhea and nausea, were no more common in patients using this drug in combination with metformin than in patients receiving metformin alone.


Postmarketing reports: Elevated liver enzymes, jaundice, cholestatic hepatitis

Nervous system

Common (1% to 10%): Dizziness


Common (1% to 10%): Back pain, arthropathy


Frequency not reported: Peripheral edema

Peripheral edema was no more common in patients using this drug in combination with rosiglitazone than in patients receiving rosiglitazone alone.


Postmarketing reports: Erythema multiforme


Common (1% to 10%): Flu symptoms


Common (1% to 10%): Accidental trauma

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Nateglinide (www.drugs.com/mtm/nateglinide.html).