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Namzaric

Generic Name: donepezil and memantine (doe NEP e zil and mem AN teen)
Brand Names: Namzaric
Namzaric (memantine/donepezil) is used to treat Alzheimer's Disease. Includes Namzaric side effects, interactions and indications.
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Drug Information:
Namzaric contains a combination of donepezil and memantine. Donepezil improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine. People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning. Memantine reduces the actions of chemicals in the brain that may contrIbute to the symptoms of Alzheimer's disease. Namzaric is used to treat moderate to severe dementia of the Alzheimer's type. Learn more

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Namzaric Side Effects

Note: This document contains side effect information about donepezil / memantine. Some of the dosage forms listed on this page may not apply to the brand name Namzaric.

In Summary

Common side effects of Namzaric include: diarrhea. Other side effects include: dizziness, nausea, vomiting, anorexia, and ecchymoses. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to donepezil / memantine: oral capsule extended release

Along with its needed effects, donepezil/memantine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking donepezil / memantine:

Incidence not known

  • Bloody or black, tarry stools
  • chest pain or discomfort
  • decreased urination
  • lightheadedness, dizziness, or fainting
  • pain in the lower abdomen, groin, upper back or sides
  • seizures
  • severe stomach pain
  • slow or irregular heartbeat
  • sweating
  • trouble breathing
  • unusual tiredness
  • vomiting of blood or material that looks like coffee grounds

Some side effects of donepezil / memantine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Constipation
  • decreased appetite
  • diarrhea
  • nausea
  • vomiting

For Healthcare Professionals

Applies to donepezil / memantine: oral capsule extended release, oral kit

Cardiovascular

Memantine:

Common (1% to 10%): Hypertension, hypotension

Postmarketing reports: Congestive cardiac failure

Donepezil:

Common (1% to 10%): Hypertension, hemorrhage, syncope

Postmarketing reports: Heart block (all types)

Nervous system

Memantine:

Common (1% to 10%): Headache, dizziness, somnolence

Donepezil:

Common (1% to 10%): Headache, dizziness, somnolence

Postmarketing reports: Convulsions, neuroleptic malignant syndrome

Gastrointestinal

Memantine:

Common (1% to 10%): Diarrhea, constipation, abdominal pain, vomiting

Postmarketing reports: Pancreatitis

Donepezil:

Very common (10% or more): Diarrhea (10%)

Common (1% to 10%): Vomiting, anorexia, nausea

Postmarketing reports: Abdominal pain, pancreatitis

Respiratory

Memantine:

Common (1% to 10%): Influenza

General

The most common adverse reactions in patients receiving memantine ER were headache, diarrhea, and dizziness. The most common adverse reactions in patients receiving donepezil were diarrhea, anorexia, vomiting, nausea, and ecchymosis.

Dermatologic

Memantine:

Postmarketing reports: Stevens Johnson Syndrome

Donepezil:

Common (1% to 10%): Eczema

Postmarketing reports: Rash

Hematologic

Memantine:

Postmarketing reports: Agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura

Donepezil:

Common (1% to 10%): Ecchymosis

Postmarketing reports: Hemolytic anemia

Hepatic

Memantine:

Postmarketing reports: Hepatitis

Donepezil:

Postmarketing reports: Cholecystitis, hepatitis

Metabolic

Donepezil:

Common (1% to 10%): Increased creatinine phosphokinase, dehydration, hyperlipidemia

Postmarketing reports: Hyponatremia

Musculoskeletal

Memantine:

Common (1% to 10%): Back pain

Donepezil:

Common (1% to 10%): Back pain

Other

Memantine:

Common (1% to 10%): Increased weight

Donepezil:

Very common (10% or more): Accident (13%), infection (11%)

Common (1% to 10%): Fever, pain, chest pain

Psychiatric

Memantine:

Common (1% to 10%): Anxiety, depression, aggression

Postmarketing reports: Suicidal ideation

Donepezil:

Common (1% to 10%): Insomnia, nervousness, hallucinations, hostility, depression, confusion, emotional lability, personality disorder

Postmarketing reports: Agitation, confusion, hallucinations

Renal

Memantine:

Common (1% to 10%): Urinary incontinence

Postmarketing reports: Acute renal failure

Donepezil:

Common (1% to 10%): Urinary incontinence

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Namzaric (www.drugs.com/namzaric.html).