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Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID). Nabumetone works by reducing hormones that cause inflammation and pain in the body.
Nabumetone is used to relieve the symptoms of rheumatoid arthritis or osteoarthritis.
Nabumetone may also be used for purposes not listed in this medication guide.
Nabumetone can increase your risk of fatal heart attack or stroke. Do not use nabumetone just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Nabumetone may also cause stomach or intestinal bleeding, which can be fatal.
Nabumetone can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Nabumetone may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using nabumetone, especially in older adults.
You should not use nabumetone if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
Tell your doctor if you have ever had:
heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
a heart attack, stroke, or blood clot;
stomach ulcers or bleeding;
asthma;
liver or kidney disease; or
fluid retention.
Taking nabumetone during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breastfeed while using this medicine.
Nabumetone is not approved for use by anyone younger than 18 years old.
Follow all directions on your prescription label and read all medication guides. Your doctor may occasionally change your dose. Use the lowest dose that is effective in treating your condition.
You may take nabumetone with or without food.
If you use nabumetone long-term, you may need frequent medical tests.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Avoid taking aspirin while you are taking nabumetone.
Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to nabumetone (such as aspirin, ibuprofen, ketoprofen, or naproxen).
Nabumetone could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Get emergency medical help if you have signs of an allergic reaction (hives, sneezing, runny or stuffy nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Stop using nabumetone and call your doctor at once if you have:
shortness of breath (even with mild exertion);
swelling or rapid weight gain;
the first sign of any skin rash, no matter how mild;
signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or
low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.
Common side effects may include:
stomach pain, indigestion, nausea;
diarrhea, constipation, gas;
swelling in your hands and feet;
headache, dizziness;
itching, skin rash; or
ringing in your ears.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Osteoarthritis:
Initial dose: 1000 mg orally once a day
Maintenance dose: 1500 to 2000 mg orally per day in 1 or 2 divided doses
Maximum dose: 2000 mg/day
Comments:
-Patients weighing less than 50 kg may be less likely to require dosages beyond 1000 mg.
-Once response to therapy is determined, dose and frequency should be adjusted to the lowest effective dose for the shortest duration possible to suit the individual patient's treatment goals.
Use: For the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Usual Adult Dose for Rheumatoid Arthritis:
Initial dose: 1000 mg orally once a day
Maintenance dose: 1500 to 2000 mg orally per day in 1 or 2 divided doses
Maximum dose: 2000 mg/day
Comments:
-Patients weighing less than 50 kg may be less likely to require dosages beyond 1000 mg.
-Once response to therapy is determined, dose and frequency should be adjusted to the lowest effective dose for the shortest duration possible to suit the individual patient's treatment goals.
Use: For the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Ask your doctor before using nabumetone if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.
Tell your doctor about all your other medicines, especially:
lithium;
methotrexate;
a blood thinner (warfarin, Coumadin, Jantoven);
heart or blood pressure medication, including a diuretic or "water pill"; or
steroid medicine (such as prednisone).
This list is not complete. Other drugs may affect nabumetone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Nabumetone (www.drugs.com/mtm/nabumetone.html).
Commonly reported side effects of nabumetone include: abdominal pain, diarrhea, and dyspepsia. Other side effects include: constipation, dizziness, edema, headache, heme positive stools, nausea, pruritus, skin rash, tinnitus, and flatulence. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to nabumetone: oral tablet
Oral route (Tablet)
NSAIDs cause an increased risk of serious or fatal cardiovascular thrombotic events, myocardial infarction, and stroke. Nabumetone is contraindicated in the setting of CABG surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.
Along with its needed effects, nabumetone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking nabumetone:
More common
Less common
Rare
Symptoms of overdose
Some side effects of nabumetone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Rare
For Healthcare Professionals
Applies to nabumetone: oral tablet
GastrointestinalVery common (10% or more): Diarrhea (14%), dyspepsia (13%), abdominal pain (12%)
Common (1% to 10%): Constipation, flatulence, nausea, positive stool guaiac, dry mouth, gastritis, stomatitis, vomiting
Uncommon (0.1% to 1%): Duodenal ulcer, GI bleeding, gastric ulcer, GI disorder, melena, stomatitis
Very rare (less than 0.01%): Pancreatitis
Frequency not reported: Anorexia, dysphagia, gastroenteritis, duodenitis, eructation, glossitis, rectal bleeding
HepaticUncommon (0.1% to 1%): Elevated liver function tests
Very rare (less than 0.01%): Hepatic failure, jaundice
Frequency not reported: Liver function abnormalities, gallstones
RenalVery rare (less than 0.01%): Renal failure, nephrotic syndrome
Frequency not reported: Albuminuria, azotemia, interstitial nephritis, renal stones
DermatologicCommon (1% to 10%): Sweating increased, pruritus, rash
Uncommon (0.1% to 1%): Photosensitivity, urticaria
Very rare (less than 0.01%): Bullous eruptions, pseudoporphyria cutanea tarda, acne, alopecia, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome, angioedema
Frequency not reported: Purpura
HematologicVery rare (less than 0.01%): Thrombocytopenia
Frequency not reported: Anemia, leukopenia, granulocytopenia, neutropenia, agranulocytosis, aplastic anemia, hemolytic anemia
HypersensitivityVery rare (less than 0.01%): Anaphylactoid reaction, anaphylaxis
Nervous systemCommon (1% to 10%): Dizziness, headache, somnolence
Uncommon (0.1% to 1%): Paresthesia
Frequency not reported: Tremor, syncope, drowsiness
PsychiatricCommon (1% to 10%): Insomnia, nervousness
Uncommon (0.1% to 1%): Confusion, anxiety
Frequency not reported: Agitation, depression, nightmares, hallucinations
CardiovascularCommon (1% to 10%): Hypertension/blood pressure increased
Frequency not reported: Vasculitis, angina, arrhythmia, myocardial infarction, palpitations, thrombophlebitis, cardiac failure
RespiratoryUncommon (0.1% to 1%): Dyspnea, respiratory disorder, epistaxis
Very rare (less than 0.01%): Interstitial pneumonitis
Frequency not reported: Asthma, cough, aggravated asthma, bronchospasm
Postmarketing reports: Eosinophilic pneumonia, hypersensitivity pneumonitis, idiopathic interstitial pneumonitis
OtherCommon (1% to 10%): Fatigue, tinnitus, edema, ear disorder
Uncommon (0.1% to 1%): Asthenia, fatigue
Frequency not reported: Malaise, vertigo, weight gain, gingivitis, taste disorder, fever, chills, weight loss, aseptic meningitis
Cases of aseptic meningitis have been reported, especially in patients with autoimmune disorders, such as systemic lupus erythematosus or mixed connective tissue disease. Symptoms have included stiff neck, headache, nausea, vomiting, fever, and disorientation.
GenitourinaryUncommon (0.1% to 1%): Urinary tract disorder
Very rare (less than 0.01%): Menorrhagia
Frequency not reported: Bilirubinuria, dysuria, hematuria, impotence
Postmarketing reports: Vaginal bleeding
MetabolicFrequency not reported: Appetite increased, hyperglycemia, hypokalemia
Postmarketing reports: Hyperuricemia
GeneralThe most frequently reported adverse effects were gastrointestinal (GI) in nature and included diarrhea, dyspepsia, and abdominal pain.
MusculoskeletalUncommon (0.1% to 1%): Myopathy
OcularUncommon (0.1% to 1%): Abnormal vision, eye disorder
Frequency not reported: Optic neuritis
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Nabumetone (www.drugs.com/mtm/nabumetone.html).
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