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Mozobil

Generic Name: plerixafor (pler IX a fore)
Brand Names: Mozobil
Mozobil helps patients with non-Hodgkin's lymphoma by releasing stem cells that can be collected and transplanted back. Learn about side effects, interactions and indications.
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Drug Information:
Mozobil (plerixafor) works by helping your bone marrow release stem cells into your bloodstream so they can be collected and transplanted back into the body. Mozobilis used in people with non-Hodgkin's lymphoma or multiple myeloma. Mozobil may also be used for purposes not listed in this medication guide. Do not receive Mozobil without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. You should not receive Mozobil if you are allergic to plerixafor, or if you have leukemia. Learn more

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Mozobil Side Effects

Note: This document contains side effect information about plerixafor. Some of the dosage forms listed on this page may not apply to the brand name Mozobil.

In Summary

Common side effects of Mozobil include: diarrhea, dizziness, injection site reaction, nausea, arthralgia, fatigue, headache, and vomiting. Other side effects include: flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to plerixafor: subcutaneous solution

Along with its needed effects, plerixafor (the active ingredient contained in Mozobil) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking plerixafor:

More common

  • Bleeding gums
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • collection of blood under the skin
  • coughing up blood
  • deep, dark purple bruise
  • difficulty in breathing or swallowing
  • dizziness
  • feeling of heat
  • flushing, redness of the skin
  • hard lump
  • headache
  • hives or welts, itching, skin rash
  • increased menstrual flow or vaginal bleeding
  • irritation
  • nosebleeds
  • pain
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • swelling
  • unusually warm skin

Rare

  • Chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • fainting
  • fast heartbeat
  • swelling around the eyes
  • tightness in the chest
  • weakness

Incidence not known

  • Cough
  • feeling of fullness
  • pain in the left upper stomach or around the left shoulder
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • stomach pain
  • unusual tiredness or weakness

Some side effects of plerixafor may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloated feeling
  • diarrhea
  • difficulty in moving
  • excess air or gas in the stomach or intestines
  • muscle pain or stiffness
  • nausea
  • pain in the joints
  • passing gas
  • trouble sleeping
  • vomiting

Less common

  • Belching
  • bone pain
  • difficulty having a bowel movement
  • dry mouth
  • general feeling of discomfort or illness
  • heartburn
  • increased sweating
  • indigestion
  • pressure in the stomach
  • stomach discomfort or upset
  • swelling of the abdominal or stomach area

Incidence not known

  • Abnormal dreams and nightmares

For Healthcare Professionals

Applies to plerixafor: subcutaneous solution

Gastrointestinal

Very common (10% or more): Diarrhea (up to 37%), nausea (up to 34%), vomiting (up to 10%)

Common (1% to 10%): Flatulence, abdominal pain, abdominal distension, dry mouth, stomach discomfort, hypoesthesia oral, constipation, dyspepsia

Local

Very common (10% or more): Injection site reactions (up to 34%)

Other

Very common (10% or more): Fatigue (up to 27%)

Common (1% to 10%): Malaise

Nervous system

Very common (10% or more): Headache (up to 22%), paresthesia (up to 20.6%), dizziness (up to 11%)

Uncommon (0.1% to 1%): Vasovagal reactions

Musculoskeletal

Very common (10% or more): Arthralgia (up to 13%)

Common (1% to 10%): Musculoskeletal pain

Dermatologic

Common (1% to 10%): Hyperhidrosis, erythema

Hematologic

Common (1% to 10%): Hyperleukocytosis

Frequency not reported: Thrombocytopenia

Psychiatric

Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Abnormal dreams, nightmares

Immunologic

Uncommon (0.1% to 1%): Allergic reactions

Postmarketing reports: Anaphylactic reactions including anaphylactic shock

Cardiovascular

Rare (less than 0.1%): Myocardial infarction

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Mozobil (www.drugs.com/mozobil.html).