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Misoprostol Prescription
Generic Name: misoprostol (mye so PRAH stole)
Brand Name: Cytotec
Physician reviewed misoprostol patient information - includes misoprostol description, dosage and directions.

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Misoprostol Drug Information:

Misoprostol reduces stomach acid and helps protect the stomach from damage that can be caused by taking a nonsteroidal anti-inflammatory drug (NSAID) such as Aspirin, Ibuprofen (Advil, Motrin), Naproxen (Aleve), Celecoxib, diclofenac, Indomethacin, Meloxicam, and others. Misoprostol is used to prevent stomach ulcers during treatment with Aspirin or an NSAID. Misoprostol may also be used for purposes not listed in this medication guide. Misoprostol can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage and dangerous uterine bleeding. Do not use misoprostol if you are pregnant. Learn more

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Misoprostol Side Effects

In Summary

Commonly reported side effects of misoprostol include: abdominal pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to misoprostol: oral tablet


Oral route (Tablet)

Administration of misoprostol to women who are pregnant can cause birth defects, abortion, premature birth, or uterine rupture. Uterine rupture has been reported when misoprostol was administered in pregnant women to induce labor or to induce abortion. The risk of uterine rupture increases with advancing gestational ages and with prior uterine surgery, including Cesarean delivery. Misoprostol should not be used for reducing the risk of NSAID-induced ulcers in women of childbearing potential unless the patient is at high risk of developing gastric ulcers or complications. Women must have a negative serum pregnancy test within 2 weeks prior to beginning therapy, use effective contraceptive measures, and initiate therapy only on the second or third day of the next normal menstrual period. Oral and written warnings of the hazards of misoprostol, including the risk of possible contraception failure, must be given to the patient prior to initiating therapy.

Along with its needed effects, misoprostol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking misoprostol:


  • Cramps
  • heavy bleeding
  • painful menstruation

Incidence not known

  • Bladder pain
  • bloody nose
  • bloody or black, tarry stools
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • chest pain
  • chills
  • confusion
  • constipation
  • cough
  • difficult, burning, or painful urination
  • difficulty with breathing
  • difficulty with moving
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • feeling unusually cold
  • fever
  • frequent urge to urinate
  • headache
  • hives, itching, or skin rash
  • loss of voice
  • lower back or side pain
  • muscle pain or stiffness
  • nasal congestion
  • nervousness
  • pain in the joints
  • pale skin
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • runny nose
  • severe stomach pain
  • shivering
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • sweating
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds

Some side effects of misoprostol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • diarrhea

Less common

  • Acid or sour stomach
  • belching
  • bloated
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • indigestion
  • passing gas
  • stomach discomfort or upset

Incidence not known

  • Blistering, crusting, irritation, itching, or reddening of the skin
  • breast pain
  • burning, dry, or itching eyes
  • change in taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cracked, dry, scaly skin
  • depression
  • discharge, excessive tearing
  • hair loss or thinning of the hair
  • hearing loss
  • lack or loss of strength
  • paleness of the skin
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • weight changes

For Healthcare Professionals

Applies to misoprostol: oral tablet


The most commonly reported side effects included uterine contractions/cramping, diarrhea, and abdominal pain.


Uterine contractions/cramping usually occurred within hours of oral administration.

Heavy bleeding required hemostatic curettage in up to 1.4% of patients.

Very common (10% or more): Uterine contractions/cramping (up to 45%)

Common (1% to 10%): Endometritis, heavy bleeding, pelvic inflammatory disease

Uncommon (0.1% to 1%): Cramps, dysmenorrhea, hypermenorrhea, intermenstrual bleeding, menstrual disorder, spotting, vaginal hemorrhage

Rare (0.01% to 0.1%): Menorrhagia

Frequency not reported: Abnormal uterine contractions, breast pain, dysuria, hematuria, impotence, polyuria, postmenopausal vaginal bleeding, urinary tract infection, uterine hemorrhage, uterine perforation, uterine rupture


Diarrhea usually occurred early in treatment, and was typically dose-related, self-limiting, and required discontinuation in approximately 2% of patients in clinical trials.

Very common (10% or more): Diarrhea (up to 40%), abdominal pain (up to 20%)

Common (1% to 10%): Constipation, dyspepsia, flatulence, nausea, vomiting

Uncommon (0.1% to 1%): Light to moderate cramping

Frequency not reported: Dysphagia, gastrointestinal bleeding, gastrointestinal inflammation and infection, gingivitis, loose stools, profound diarrhea, rectal disorder, reflux

Nervous system

Vagal symptoms included hot flush, dizziness, and chills.

Common (1% to 10%): Dizziness, headache

Rare (0.01% to 0.1%): Vagal symptoms

Frequency not reported: Abnormal taste, drowsiness, neuropathy, syncope


Common (1% to 10%): Infection following abortion

Uncommon (0.1% to 1%): Fever/pyrexia

Rare (0.01% to 0.1%): Birth defects, chills, fetal death, malaise

Very rare (less than 0.01%): Serious/fatal septic shock, serious/fatal toxic shock

Frequency not reported: Aches/pains, asthenia, deafness, earache, fatigue, incomplete abortion, premature birth, retained placenta, rigors, tinnitus


Common (1% to 10%): Skin rash/rash

Rare (0.01% to 0.1%): Erythema nodosum, erythroderma, toxic epidermal necrolysis, urticaria

Frequency not reported: Alopecia, dermatitis, diaphoresis/increased sweating


Rare (0.01% to 0.1%): Hot flushes

Frequency not reported: Amniotic fluid embolism, arrhythmia, arterial thrombosis, cardiovascular accidents, cerebrovascular accident, chest pain, coronary artery spasm, edema, hypertension, hypotension, increased cardiac enzymes, myocardial infarction/fatal myocardial infarction, pallor, phlebitis, severe hypotension, thromboembolic events


Very rare (less than 0.01%): Angioedema

Frequency not reported: Anaphylactic reaction, anaphylaxis, hypersensitivity


Frequency not reported: Bronchitis, bronchospasm, dyspnea, epistaxis, pneumonia, pulmonary embolism, upper respiratory tract infection


Frequency not reported: Appetite change, gout, increased alkaline phosphatase, increased nitrogen, severe dehydration, thirst, weight changes


Frequency not reported: Abnormal differential, anemia, increased erythrocyte sedimentation rate, purpura, thrombocytopenia


Frequency not reported: Anxiety, confusion, depression, loss of libido, neurosis


Frequency not reported: Arthralgia, back pain, myalgia, muscle cramps. stiffness


Frequency not reported: Abnormal vision, conjunctivitis


Frequency not reported: Abnormal hepatobiliary function


Frequency not reported: Glycosuria

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Misoprostol (www.drugs.com/mtm/misoprostol.html).