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Mirtazapine Prescription
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Generic Name: mirtazapine (mir TAZ a peen)
Brand Names: Remeron, Remeron SolTab
Mirtazapine (Remeron) is an antidepressant used to treat major depressive disorder. Includes mirtazapine side effects, interactions and indications. Average Savings for mirtazapine (generic): 58.27%
Generic Name: mirtazapine (mir TAZ a peen)
Brand Names: Remeron, Remeron SolTab
Mirtazapine (Remeron) is an antidepressant used to treat major depressive disorder. Includes mirtazapine side effects, interactions and indications. Average Savings for mirtazapine (generic): 58.27%
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30 tablets of Mirtazapine 40 mg
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Mirtazapine Drug Information:

Mirtazapine is an antidepressant. The way this medication works is still not fully understood. It is thought to positively affect communication between nerve cells in the central nervous system and/or restore chemical balance in the brain. Mirtazapine is used to treat major depressive disorder. Mirtazapine may also be used for purposes not listed in this medication guide. You should not take mirtazapine if you are also taking Tryptophan (sometimes called L-Tryptophan). Do not use mirtazapine if you have used an MAO inhibitor or Methylene Blue injection n the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, Linezolid, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Learn more

Mirtazapine Side Effects

In Summary

Commonly reported side effects of mirtazapine include: severe sedation, constipation, drowsiness, increased serum cholesterol, weight gain, fatigue, insomnia, increased appetite, xerostomia, and decreased appetite. Other side effects include: dizziness, increased serum triglycerides, tremor, dyspepsia, hot flash, palpitations, vertigo, abnormal dreams, bitter taste, decreased libido, and diaphoresis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to mirtazapine: oral tablet, oral tablet disintegrating


Oral route (Tablet; Tablet, Disintegrating)

Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder and other psychiatric disorders in short-term studies. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared with placebo in adults aged 65 or older. This risk must be balanced with the clinical need. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Mirtazapine is not approved for use in pediatric patients.

Along with its needed effects, mirtazapine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mirtazapine:

Less common

  • Decreased or increased movement
  • mood or mental changes, including abnormal thinking, agitation, anxiety, confusion, and feelings of not caring
  • shortness of breath
  • skin rash
  • swelling


  • Change in menstrual cycle (periods)
  • convulsions (seizures)
  • decreased sexual ability
  • menstrual pain
  • mood or mental changes, including anger, feelings of being outside the body, hallucinations (seeing, hearing, or feeling things that are not there), mood swings, and unusual excitement
  • mouth sores
  • sore throat, chills, or fever

Some side effects of mirtazapine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • dizziness
  • drowsiness
  • dry mouth
  • increased appetite
  • weight gain

Less common

  • Abdominal or stomach pain
  • abnormal dreams
  • back pain
  • dizziness or fainting when getting up suddenly from a lying or sitting position
  • increased need to urinate
  • increased sensitivity to touch
  • increased thirst
  • low blood pressure
  • muscle pain
  • nausea
  • sense of constant movement of self or surroundings
  • trembling or shaking
  • vomiting
  • weakness

For Healthcare Professionals

Applies to mirtazapine: oral tablet, oral tablet disintegrating

Nervous system

Very common (10% or more): Somnolence (up to 54%)

Common (1% to 10%): Dizziness, tremor, headache, sedation/drowsiness

Uncommon (0.1% to 1%): Hypesthesia, hypokinesia, vertigo, amnesia, hyperkinesia, paresthesia, lethargy

Rare (0.01% to 0.1%): Syncope, migraine, ataxia, dyskinesia, extrapyramidal syndrome, coordination abnormal, dysarthria, dystonia, reflexes increased, restless legs, akathisia (psychomotor restlessness)

Very rare (less than 0.01%): Vascular headache, cerebral ischemia, aphasia, nystagmus, stupor, dementia, paralysis, grand mal convulsion, hypotonia, taste loss, myoclonus, parosmia

Frequency not reported: Hypertonia, taste perversion, convulsions (insults)

Postmarketing reports: Impaired concentration, cerebrovascular disorder, movement disorders


Very common (10% or more): Dry mouth (up to 25%), constipation (up to 13%)

Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Abdominal pain, abdominal syndrome acute, vomiting, diarrhea

Rare (0.01% to 0.1%): Abdomen enlarged, eructation, glossitis, nausea and vomiting, gum hemorrhage, stomatitis, colitis, oral hypoesthesia

Very rare (less than 0.01%): Tongue discoloration, ulcerative stomatitis, salivary gland enlargement, increased salivation, intestinal obstruction, pancreatitis, aphthous stomatitis, gastritis, gastroenteritis, oral moniliasis, tongue edema

Frequency not reported: Dyspepsia, flatulence, oral paresthesia, mouth edema


Very common (10% or more): Increased appetite (up to 17%), weight gain (up to 12%)

Uncommon (0.1% to 1%): Anorexia

Rare (0.01% to 0.1%): Dehydration, weight loss

Very rare (less than 0.01%): Gout, acid phosphatase increased, diabetes mellitus, hyponatremia

Frequency not reported: Hypertriglyceridemia

Postmarketing reports: Hypercholesterolemia, hyperlipidemia


Common (1% to 10%): Abnormal dreams, thinking abnormal, confusion

Uncommon (0.1% to 1%): Apathy, depression, agitation, anxiety, insomnia

Rare (0.01% to 0.1%): Delirium, delusions, depersonalization, increased libido, hallucinations, manic reaction/mania, neurosis, hostility, emotional lability, euphoria, paranoid reaction, nightmares/vivid dreams

Very rare (less than 0.01%): Drug dependence, psychotic depression, withdrawal syndrome, serotonin syndrome, aggression

Frequency not reported: Nervousness, decreased libido, suicidal ideation, suicidal behavior, somnambulism

Postmarketing reports: Psychomotor restlessness, drug withdrawal symptoms, paroniria


Common (1% to 10%): Peripheral edema, edema

Uncommon (0.1% to 1%): Hypertension, vasodilation, orthostatic hypotension

Rare (0.01% to 0.1%): Angina pectoris, myocardial infarction, bradycardia, ventricular extrasystoles, hypotension

Very rare (less than 0.01%): Chest pain substernal, atrial arrhythmia, bigeminy, cardiomegaly, phlebitis, left heart failure

Frequency not reported: Chest pain, palpitation, tachycardia, postural hypotension, ECG changes

Postmarketing reports: Ventricular arrhythmia, Torsades de pointes, generalized edema, localized edema

There was a mean increase in heart rate observed in patients given this drug compared to placebo (3.4 bpm versus 0.8 bpm, respectively); however, the clinical significance of this difference is unknown.


Common (1% to 10%): Back pain, myalgia

Uncommon (0.1% to 1%): Myasthenia, arthralgia, twitching

Rare (0.01% to 0.1%): Neck rigidity, neck pain, arthritis, tenosynovitis

Very rare (less than 0.01%): Pathologic fracture, osteoporosis fracture, bone pain, myositis, tendon rupture, arthrosis, bursitis

Postmarketing reports: Increased creatine kinase blood levels, rhabdomyolysis


Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Cough increased, sinusitis

Rare (0.01% to 0.1%): Epistaxis, bronchitis, asthma, pneumonia

Very rare (less than 0.01%): Respiratory/pulmonary embolus, asphyxia, laryngitis, pneumothorax, hiccup

Frequency not reported: Pharyngitis, rhinitis

Postmarketing reports: Pulmonary embolism


Common (1% to 10%): Urinary frequency

Uncommon (0.1% to 1%): Urinary tract infection

Rare (0.01% to 0.1%): Dysuria, urinary incontinence, urinary retention, vaginitis, hematuria, breast pain, amenorrhea, dysmenorrhea, leukorrhea, impotence

Very rare (less than 0.01%): Polyuria, urethritis, metrorrhagia, abnormal ejaculation, breast engorgement, breast enlargement, urinary urgency, menorrhagia


Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Malaise, thirst, fatigue

Rare (0.01% to 0.1%): Chills, fever, face edema, ulcer, ear pain, deafness, hyperacusis

Very rare (less than 0.01%): Healing abnormal, partial transitory deafness, otitis media

Frequency not reported: Pain, tinnitus


Common (1% to 10%): Influenza/flu syndrome

Frequency not reported: Infection


Uncommon (0.1% to 1%): Pruritus, rash, exanthema

Rare (0.01% to 0.1%): Photosensitivity reaction, acne, exfoliative dermatitis, dry skin, herpes simplex, alopecia

Very rare (less than 0.01%): Cellulitis, petechia, urticaria, herpes zoster, skin hypertrophy, skin ulcer, seborrhea

Frequency not reported: Sweating

Postmarketing reports: Stevens-Johnson Syndrome, bullous dermatitis, erythema multiforme, toxic epidermal necrolysis, rash (including erythematous and maculopapular)


Rare (0.01% to 0.1%): Eye pain, abnormality of accommodation, conjunctivitis, keratoconjunctivitis, lacrimation disorder, angle-closure glaucoma

Very rare (less than 0.01%): Diplopia, blepharitis

Frequency not reported: Amblyopia

Postmarketing reports: Glaucoma


Rare (0.01% to 0.1%): Cholecystitis, liver function tests abnormal

Very rare (less than 0.01%): Cirrhosis of the liver, AST increased, ALT increased

Postmarketing reports: Jaundice, hepatitis


Rare (0.01% to 0.1%): Kidney calculus, cystitis


Very rare (less than 0.01%): Lymphadenopathy, leukopenia, anemia, thrombocytopenia, lymphocytosis, pancytopenia

Frequency not reported: Bone marrow depression (granulocytopenia, agranulocytosis, aplastic anemia, thrombocytopenia), eosinophilia

Postmarketing reports: Thromboembolic disorder, coagulation disorder


Very rare (less than 0.01%): Goiter, hypothyroidism

Frequency not reported: Inappropriate antidiuretic hormone secretion

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Mirtazapine (www.drugs.com/mirtazapine.html).