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Applies to minoxidil topical: topical foam, topical solution
Along with its needed effects, minoxidil topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking minoxidil topical:
Less common
Rare
Signs and symptoms of too much medicine being absorbed into the body—Rare
For Healthcare Professionals
Applies to minoxidil topical: topical foam, topical solution
GeneralMinoxidil topical is generally well tolerated. Dermatological adverse events are the only side effects reported more commonly as compared to placebo.
CardiovascularEdema, salt and water retention, pericardial effusion, pericarditis, tamponade, tachycardia, and angina have been reported with oral minoxidil. Patients with underlying heart disease may be at increased risk for these or other cardiovascular adverse effects.
Rarely, cardiovascular side effects have included edema, chest pain, blood pressure changes, palpitations, and changes in pulse rate with minoxidil topical therapy.
LocalDespite low levels of systemic absorption, in one study of 35 men using either topical minoxidil 2% twice a day or placebo for 6 months, minoxidil was associated with cardiac changes, such as significant increases in left ventricular end-diastolic volume, cardiac output, and left ventricular mass.
Systemic side effects are uncommon since very little minoxidil is absorbed after topical application. In one study, the serum levels after 2.5 mg twice a day oral versus 2% twice a day topical minoxidil were 32.8 and 1.7 ng per mL, respectively.
Exacerbation of hair loss/alopecia has been reported.
DermatologicRare cases of generalized hypertrichosis have been associated with topically applied minoxidil. Eczema, irritant dermatitis, and allergic contact dermatitis have also been reported.
HypersensitivityNonspecific allergic reactions, hives, allergic rhinitis, facial swelling, and sensitivity to minoxidil topical have rarely been reported.
Nervous systemHeadache, dizziness, faintness, and light-headedness have been reported with minoxidil topical.
GastrointestinalDiarrhea, nausea, and vomiting have been reported during treatment with minoxidil topical.
OcularVisual disturbances, including decreased visual acuity, have been reported.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Minoxidil (www.drugs.com/mtm/minoxidil-topical.html).
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