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Minocycline Hydrochloride

Minocycline hydrochloride Prescription
Generic Name: minocycline topical (MYE no SYE kleen TOP i kal)
Brand Name: Amzeeq
Physician reviewed minocycline topical patient information - includes minocycline topical description, dosage and directions.

Average Savings for minocycline hydrochloride (generic): 37.92%
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Minocycline Hydrochloride Drug Information:

Minocycline is a tetracycline antibiotic. Minocycline topical (for the skin) is used to treat severe acne in adults and children at least 9 years old. minocycline topical is not for use in treating a skin infection. Minocycline topical may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. You should not use minocycline topical if you are allergic to minocycline or to similar antibiotics such as demeclocycline, Doxycycline, or tetracycline. Learn more

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Minocycline Hydrochloride Side Effects

For the Consumer

Applies to minocycline topical: subgingival powder

Other dosage forms:

  • topical application foam
Side effects requiring immediate medical attention

Along with its needed effects, minocycline topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking minocycline topical:

More common

  • Bleeding from the gums
  • chills
  • dental pain
  • fever
  • pain, redness, and swelling in the mouth
  • problems with teeth
  • redness or swelling of the gums
  • toothache

Less common

  • Bad taste in the mouth
  • discharge from the gums
  • foul breath odor
  • painful sores in the mouth
  • problems in the lining of the mouth
Side effects not requiring immediate medical attention

Some side effects of minocycline topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache

Less common

  • Acid or sour stomach
  • belching
  • cough
  • heartburn
  • increased sensitivity to sunlight
  • indigestion
  • pain
  • pain in the joints or muscles
  • runny nose
  • sneezing
  • sore throat
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to minocycline topical: mucous membrane insert, topical foam


Minocycline topical powder is intended for local application only. Systemic effects from the absorption of small amounts of the drug are unlikely.


Other side effects have included headache (9%) and pain (4.3%).


Dermatologic side effects have included stomatitis (6.4%), mouth ulceration (5%), and mucous membrane disorder (3.3%).


Gastrointestinal side effects have included dyspepsia (4%).


Local side effects have included periodontitis (16.3%), tooth disorder (12.3%), tooth caries (9.9%), dental pain (9.9%), gingivitis (9.2%), pharyngitis (4.3%), and dental infection (3.8%).


Immunologic side effects have included flu syndrome (5%) and infection (7.6%).

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Minocycline Hydrochloride (www.drugs.com/mtm/minocycline-topical.html).