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Midodrine Hcl

Midodrine hcl Prescription
Generic Name: midodrine (MY doe drin)
Brand Name: ProAmatine, Orvaten
Physician reviewed midodrine patient information - includes midodrine description, dosage and directions.

Average Savings for midodrine hcl (generic): 30.62%
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Midodrine Hcl Drug Information:

Midodrine works by constricting (narrowing) the blood vessels and increasing blood pressure. Midodrine is used to treat low blood pressure (hypotension) that causes severe dizziness or a light-headed feeling, like you might pass out. midodrine is for use only when low blood pressure affects daily life. Midodrine may not improve your ability to perform daily activities. Midodrine may also be used for purposes not listed in this medication guide. You should not use midodrine if you have severe heart disease, overactive Thyroid, an adrenal gland tumor, kidney disease, if you are unable to urinate, or if your blood pressure is high even while lying down. Learn more

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Midodrine Hcl Side Effects

In Summary

Commonly reported side effects of midodrine include: dysuria, paresthesia, pruritus, supine hypertension, and piloerection. Other side effects include: abdominal pain, pain, and chills. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to midodrine: oral tablet


Oral route (Tablet)

Can cause marked elevation of supine blood pressure and should be used only in patients whose lives are considerably impaired despite standard clinical care. Clinical benefits of midodrine hydrochloride tablets, principally improved ability to carry out activities of daily living, have not been verified.

Side effects requiring immediate medical attention

Along with its needed effects, midodrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking midodrine:

More common

  • Blurred vision
  • cardiac awareness
  • headache
  • pounding in the ears


  • Fainting
  • increased dizziness
  • slow pulse
Side effects not requiring immediate medical attention

Some side effects of midodrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Burning, itching, or prickling of the scalp
  • chills
  • goosebumps
  • urinary frequency, retention, or urgency

Less common

  • Anxiety or nervousness
  • confusion
  • dry mouth
  • flushing
  • headache or feeling of pressure in the head
  • skin rash


  • Backache
  • canker sores
  • dizziness
  • drowsiness
  • dry skin
  • leg cramps
  • pain or sensitivity of the skin to touch
  • stomach problems such as gas, heartburn, or nausea
  • trouble seeing
  • trouble with sleeping
  • weakness

For Healthcare Professionals

Applies to midodrine: oral tablet


The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.


Common (1% to 10%): Supine hypertension, flushing

Uncommon (0.1% to 1%): Reflex bradycardia

Rare (less than 0.1%): Tachycardia, palpitations

Frequency not reported: Vasodilation/flushing face

Nervous system

Very common (10% or more): Paresthesia (18.3%)

Common (1% to 10%): Headache

Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence


Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)

Common (1% to 10%): Rash

Frequency not reported: Skin hyperesthesia, erythema multiforme, dry skin


Very common (10% or more): Dysuria (13.4%)

Frequency not reported: Impaired urination


Common (1% to 10%): Nausea, dyspepsia, stomatitis

Frequency not reported: Dry mouth, canker sore, pyrosis, gastrointestinal distress, flatulence, abdominal pain, vomiting, diarrhea


Common (1% to 10%): Chills, pain

Frequency not reported: Asthenia


Uncommon (0.1% to 1%): Sleep disorders, insomnia, restlessness, excitability, irritability

Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety


Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes


Frequency not reported: Backache, leg cramps


Frequency not reported: Visual field defect

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Midodrine Hcl (www.drugs.com/mtm/midodrine.html).