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In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.
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Methylprednisolone is a corticosteroid medicine that prevents the release of substances in the body that cause inflammation.
Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells.
Methylprednisolone may also be used for purposes not listed in this medication guide.
You should not use this medicine if you have a fungal infection anywhere in your body.
Before taking methylprednisolone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.
Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. Do not receive a "live" vaccine while using this medicine. The vaccine may not work as well during this time, and may not fully protect you from disease.
Do not stop using methylprednisolone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Any doctor, dentist, or emergency medical professional who treats you should know that you take steroid medication.
You should not use methylprednisolone if you are allergic to it, or if you have:
a fungal infection anywhere in your body.
Methylprednisolone can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
a thyroid disorder;
herpes infection of the eyes;
stomach ulcers, ulcerative colitis, or diverticulitis;
depression, mental illness, or psychosis;
liver disease (especially cirrhosis);
high blood pressure;
osteoporosis;
a muscle disorder such as myasthenia gravis; or
multiple sclerosis.
Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether methylprednisolone passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
Take methylprednisolone exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Methylprednisolone is sometimes taken every other day. Follow your doctor's dosing instructions very carefully.
Your dose needs may change if you have unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using methylprednisolone.
You should not stop using this medicine suddenly. Follow your doctor's instructions about tapering your dose.
Wear a medical alert tag or carry an ID card stating that you take methylprednisolone. Any medical care provider who treats you should know that you take steroid medication.
If you need surgery, tell the surgeon ahead of time that you are using this medicine. You may need to stop using the medicine for a short time.
Store at room temperature away from moisture and heat.
Call your doctor for instructions if you miss a dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
An overdose of methylprednisolone is not expected to produce life threatening symptoms. However, long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.
Do not receive a "live" vaccine while using methylprednisolone. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, oral typhoid, yellow fever, varicella (chickenpox), and nasal flu (influenza) vaccine.
Get emergency medical help if you have signs of an allergic reaction to methylprednisolone: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
shortness of breath (even with mild exertion), swelling, rapid weight gain;
bruising, thinning skin, or any wound that will not heal;
blurred vision, tunnel vision, eye pain, or seeing halos around lights;
severe depression, changes in personality, unusual thoughts or behavior;
new or unusual pain in an arm or leg or in your back;
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
seizure (convulsions); or
low potassium - leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling.
Steroids can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.
Common methylprednisolone side effects may include:
fluid retention (swelling in your hands or ankles);
dizziness, spinning sensation;
changes in your menstrual periods;
headache;
mild muscle pain or weakness; or
stomach discomfort, bloating.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Other drugs may interact with methylprednisolone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use methylprednisolone only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Methylprednisolone (www.drugs.com/methylprednisolone.html).
Applies to methylprednisolone: oral tablet
Other dosage forms:
Along with its needed effects, methylprednisolone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking methylprednisolone:
Incidence not known
Some side effects of methylprednisolone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to methylprednisolone: compounding powder, injectable powder for injection, injectable suspension, oral tablet
GeneralThe most commonly occurring side effects have included fluid retention, alteration in glucose tolerance, increased blood pressure, behavioral and mood changes, increased appetite, and weight gain; the incidence generally correlates with dosage, timing of administration, and duration of treatment.
HypersensitivityFrequency not reported: Allergic or hypersensitivity reactions; anaphylactoid reaction, anaphylaxis, angioedema, bronchospasm
A European review describes cases of allergic reactions, including bronchospasm and anaphylaxis, in patients allergic to cows milk proteins receiving injectable methylprednisolone products containing lactose of bovine origin. In most cases, the patients were younger than 12 years old and had childhood asthma. In some cases, the reaction was mistaken as lack of efficacy, and additional doses of were give with subsequent worsening of the patients condition. The European Union has recommended lactose-containing methylprednisolone products be reformulated to remove any trace of milk proteins by 2019.
CardiovascularFrequency not reported: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis, edema, hypotension
EndocrineFrequency not reported: Cushingoid state, hirsutism, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), moon face
GastrointestinalFrequency not reported: Abdominal distention, nausea, pancreatitis, peptic ulcer, perforation of the small and large intestine, ulcerative esophagitis, gastric hemorrhage, vomiting, abdominal pain, diarrhea, dyspepsia, nausea
HepaticReversible transaminase elevations (AST, ALT) have been observed following corticosteroid therapy. These changes have generally been small and not associated with any clinical syndrome. Toxic hepatitis has been reported with high doses of cyclically pulsed IV therapy, onset has been several weeks or longer. Resolution has been reported with discontinuation; however, recurrence has been reported with rechallenge.
Frequency not reported: Hepatomegaly, elevation in liver enzymes, toxic hepatitis
MetabolicFrequency not reported: Decreased carbohydrate and glucose tolerance, manifestations of latent diabetes, hypokalemic alkalosis, potassium loss, sodium retention, increased appetite, negative nitrogen balance due to protein catabolism, weight gain, metabolic acidosis, dyslipidemia, lipomatosis
MusculoskeletalFrequency not reported: Suppression of growth in pediatric patients, aseptic necrosis of femoral and humeral heads, calcinosis, Charcot-like atrophy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, postinjection flare, steroid myopathy, tendon rupture, particularly of the Achilles tendon, vertebral compression fractures, myalgia, muscle atrophy, osteonecrosis, neuropathic arthralgia, growth retardation
HematologicFrequency not reported: Leucocytosis
ImmunologicFrequency not reported: Opportunistic infection
OcularFrequency not reported: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, blindness, chorioretinopathy
Blindness has been reported with corticosteroid injection to scalp, tonsillar fauces, sphenopalatine ganglion.
PsychiatricFrequency not reported: Depression, emotional instability, euphoria, insomnia, mood swings, personality changes, psychic disorders, confusional states, anxiety, abnormal behavior, irritability
DermatologicFrequency not reported: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scaly skin, ecchymosis, petechiae, erythema, hyperpigmentation, hypopigmentation, impaired wound healing, increased sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria, hypertrichosis, angioedema, skin atrophy, hyperhidrosis, pruritus
LocalFrequency not reported: Injection site infections, injection site reactions
Nervous systemFrequency not reported: Convulsions, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, neuritis, neuropathy, paresthesia, amnesia, dizziness
OtherFrequency not reported: Vertigo, abnormal fat deposits, malaise, sterile abscess, impaired healing, fatigue
OncologicFrequency not reported: Kaposi's sarcoma
RespiratoryFrequency not reported: Pulmonary edema, pulmonary embolism, hiccups
GenitourinaryFrequency not reported: Menstrual irregularities, increased or decreased motility and number of spermatozoa, increased urine calcium, glycosuria
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Methylprednisolone (www.drugs.com/methylprednisolone.html).
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