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Applies to methylene blue: intravenous solution
Intravenous route (Solution)
Methylene blue may cause serious or fatal serotonergic syndrome when used in combination with serotonergic drugs. Avoid concomitant use of methylene blue with selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors.
Along with its needed effects, methylene blue may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking methylene blue:
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking methylene blue:
Symptoms of overdose
Some side effects of methylene blue may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to methylene blue: compounding powder, injectable solution, intravenous solution, oral tablet
CardiovascularCommon (1% to 10%): Chest pain, chest discomfort, presyncope, syncope
Frequency not reported: Cardiac arrhythmia, tachycardia, hypertension, hypotension, palpitations
HematologicCommon (1% to 10%): Ecchymosis
Frequency not reported: Hemolytic anemia, hemolysis, methemoglobinemia, hemoglobin decreased, hyperbilirubinemia (in infants only)
HypersensitivityFrequency not reported: Anaphylaxis
ImmunologicCommon (1% to 10%): Influenza-like illness
LocalCommon (1% to 10%): Injection site pain, injection site discomfort
Frequency not reported: Infusion site extravasation, infusion site induration, infusion site pruritus, infusion site swelling, infusion site urticaria, peripheral swelling
MusculoskeletalVery common (10% or more): Pain in extremity (84%)
Common (1% to 10%): Musculoskeletal pain, back pain, muscle spasms, chills, arthralgia
Frequency not reported: Serotonin syndrome, myalgia
OcularFrequency not reported: Mydriasis, eye pruritus, ocular hyperemia, vision blurred
MetabolicCommon (1% to 10%): Decreased appetite, limb discomfort
Frequency not reported: Local tissue necrosis at the injection site
PsychiatricCommon (1% to 10%): Anxiety
Frequency not reported: Confusional state, agitation
GenitourinaryVery common (10% or more): Chromaturia (blue-green) (74%)
Frequency not reported: Dysuria
HepaticFrequency not reported: Elevated liver enzymes
RespiratoryCommon (1% to 10%): Dyspnea
Frequency not reported: Dyspnea, tachypnea, hypoxia, nasal congestion, rhinorrhea, sneezing
OtherVery common (10% or more): Feeling hot (17%), fever
Common (1% to 10%): Feeling cold, discomfort, catheter site pain
Frequency not reported: Genotoxicity, fever, lack of effectiveness, interference with in-vivo monitoring devices, interference with laboratory tests
Nervous systemVery common (10% or more): Dysgeusia (20%), dizziness (16%), headache (10%), paresthesia
Common (1% to 10%): Headache, paresthesia oral, dizziness postural
Frequency not reported: Serotonin syndrome (with concomitant use of serotonergic drugs), tremor, aphasia, tremor, aphasia
DermatologicVery common (10% or more): Skin discoloration (blue) (13%), hyperhidrosis (13%), sweating
Common (1% to 10%): Pallor, contact dermatitis, pruritus, cold sweat, erythema
Frequency not reported: Urticaria, necrotic ulcer, papule, phototoxicity, rash (blue macules, severe burning pain)
GastrointestinalVery common (10% or more): Nausea (13%)
Common (1% to 10%): Vomiting, abdominal pain, diarrhea, hypoesthesia oral, oral discomfort
Frequency not reported: Feces discoloration (blue-green), dry mouth, flatulence, glossodynia, tongue eruption, thirst, oropharyngeal pain, blue colored saliva
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Methylene Blue (www.drugs.com/mtm/methylene-blue-injection.html).
March 27, 2021
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