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Methimazole prevents the thyroid gland from producing too much thyroid hormone.
Methimazole is used to treat hyperthyroidism (overactive thyroid). It is also used before thyroid surgery or radioactive iodine treatment.
Methimazole may also be used for purposes not listed in this medication guide.
You should not breast-feed while using methimazole.
You should not use methimazole if you are allergic to it, or:
if you are pregnant or breast-feeding.
To make sure methimazole is safe for you, tell your doctor if you have:
liver disease;
a blood cell disorder; or
a weak immune system.
Using methimazole during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medicine.
Methimazole can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
Do not give this medicine to a child without medical advice.
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use methimazole in larger or smaller amounts or for longer than recommended.
Methimazole is usually taken every 8 hours. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times.
If a child is using this medicine, tell your doctor if the child has any changes in weight. Methimazole doses are based on weight in children, and any changes may affect your child's dose.
Methimazole can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often.
Use methimazole regularly to get the most benefit, even if you feel fine or have no symptoms of hyperthyroidism. Get your prescription refilled before you run out of medicine completely.
If you need surgery, tell the surgeon ahead of time that you are using methimazole.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include nausea, vomiting, upset stomach, headache, joint pain, fever, itching, swelling, or pale skin and easy bruising or bleeding.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Serious and sometimes fatal infections may occur during treatment with methimazole. Stop using methimazole and call your doctor right away if you have signs of infection such as:
sudden weakness or ill feeling, fever, chills, sore throat, cold or flu symptoms;
painful mouth sores, pain when swallowing, red or swollen gums; or
pale skin, easy bruising, unusual bleeding.
Call your doctor at once if you have:
swollen glands in your neck or jaw; or
liver problems--nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
nausea, vomiting, upset stomach;
headache, dizziness, drowsiness;
numbness or tingly feeling;
rash, itching, skin discoloration;
muscle or joint pain;
hair loss; or
decreased sense of taste.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Hyperthyroidism:
Initial dose:
Mild hyperthyroidism: 15 mg orally per day
Moderately severe hyperthyroidism: 30 to 40 mg orally per day
Severe hyperthyroidism: 60 mg orally per day
Maintenance dose:
5 to 15 mg orally per day
Comments: Daily doses are usually given in 3 divided doses at approximately 8 hour intervals
Uses:
-For the treatment of Graves' disease with hyperthyroidism or toxic multinodular goiter in whom surgery or radioactive iodine therapy is not an appropriate treatment option.
-To ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy.
Usual Pediatric Dose for Hyperthyroidism:
Initial dose: 0.4 mg/kg orally per day
Maintenance dose: 0.2 mg/kg orally per day (approximately half the initial dose)
Comments: Daily doses are usually given in 3 divided doses at approximately 8 hour intervals
Tell your doctor about all your current medicines and any you start or stop using, especially:
digoxin, digitalis, theophylline;
a blood thinner--warfarin, Coumadin, Jantoven; or
a beta blocker--atenolol, carvedilol, labetalol, metoprolol, nadolol, propranolol, sotalol, and others.
This list is not complete. Other drugs may interact with methimazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Methimazole (www.drugs.com/mtm/methimazole.html).
Applies to methimazole: oral tablet
Along with its needed effects, methimazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking methimazole:
Rare
Incidence not known
Some side effects of methimazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to methimazole: compounding powder, oral tablet
Some of the more frequently reported adverse reactions have included skin rash, urticaria, nausea, loss of taste, and abnormal loss of hair.
The onset of aplastic anemia (pancytopenia) or agranulocytosis may occur in hours to days. Most cases of agranulocytosis occur within the first 90 days of treatment, but this complication can occur even a year or more after starting therapy.
Studies have suggested that the risk of agranulocytosis is greater in older patients and that they have a higher rate of death.
Frequency not reported: Lymphadenopathy, agranulocytosis, granulocytopenia, thrombocytopenia, aplastic anemia, hypoprothrombinemia
Frequency not reported: Lupus-like syndrome
Frequency not reported: Jaundice, hepatitis
Frequency not reported: Edema, periarteritis
A 5-year-old female experienced aplasia cutis congenita coincident with in utero exposure to methimazole. She presented with hairless scars on her scalp. At birth the lesions were friable and bled easily, however, over time they became scar-like and thicker. At the time of conception, her mother was receiving therapy for Graves' disease with methimazole 20 mg daily. Aplasia cutis congenita has been reported as a possible teratogenic effect of methimazole therapy in multiple case reports. However, the causal relationship between the therapy and the skin defect is controversial, and anomalies related to methimazole have low birth prevalence.
Frequency not reported: Skin rash, urticaria, abnormal loss of hair, pruritus, skin pigmentation
Frequency not reported: Arthralgia, myalgia
Frequency not reported: Paresthesia, loss of taste, headache, drowsiness, neuritis
Frequency not reported: Nausea, vomiting, epigastric distress, sialadenopathy
Very rare (less than 0.01%): Nephritis
Frequency not reported: Insulin autoimmune syndrome
Frequency not reported: Vertigo, drug fever
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Methimazole (www.drugs.com/mtm/methimazole.html).
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