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Malarone

Generic Name: atovaquone and proguanil (a TOE va kwone and pro GWAHN il)
Brand Names: Malarone, Malarone Pediatric
Malarone (atovaquone and proguanil) is an antiprotozoal and antimalarial and is used to treat or prevent malaria. Includes Malarone side effects, interactions and indications.

Average Savings for atovaquone/proguanil hcl (generic): 10.42%
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Drug Information:
Malarone contains a combination of atovaquone and proguanil. Atovaquone and proguanil are medications used to treat malaria, a disease caused by parasites. Malarone works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Malarone is used to treat or prevent malaria. Malarone may also be used for purposes not listed in this medication guide. Learn more

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Malarone Side Effects

Note: This document contains side effect information about atovaquone / proguanil. Some of the dosage forms listed on this page may not apply to the brand name Malarone.

For the Consumer

Applies to atovaquone / proguanil: oral tablet

Along with its needed effects, atovaquone/proguanil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking atovaquone / proguanil:

Incidence not known

  • Blistering, peeling, loosening of skin
  • chills
  • convulsions
  • difficulty swallowing
  • fast heartbeat
  • hives or welts
  • increased sensitivity of skin to sunlight
  • itching, redness or other discoloration of skin
  • joint or muscle pain
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
  • loss of bladder control
  • muscle spasm or jerking of all extremities
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • seeing, hearing, or feeling things that are not there
  • severe mental changes
  • severe sunburn
  • shortness of breath
  • skin rash
  • sores, ulcers or white spots in mouth or on lips
  • sudden loss of consciousness
  • tightness in chest
  • unusual tiredness or weakness
  • wheezing

Some side effects of atovaquone / proguanil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal pain
  • back pain
  • coughing
  • diarrhea
  • dreams
  • fever
  • headache
  • itching skin
  • lack of or loss of strength
  • nausea
  • muscle pain
  • sore throat
  • sores in mouth
  • sneezing
  • vomiting

Less common

  • Acid or sour stomach
  • belching
  • blurred or loss of vision
  • disturbed color perception
  • dizziness
  • double vision
  • flu like symptoms
  • halos around lights
  • heartburn
  • indigestion
  • loss of appetite
  • night blindness
  • overbright appearance of lights
  • sleeplessness
  • stomach discomfort, upset or pain
  • trouble sleeping
  • tunnel vision
  • unable to sleep
  • weight loss

Rare

  • Discouragement
  • fear
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • nervousness
  • trouble concentrating

For Healthcare Professionals

Applies to atovaquone / proguanil: oral tablet

General

In general, side effects associated with the use of atovaquone-proguanil have been mild. Side effects are more pronounced and occur more frequently when higher doses are used in the treatment of malaria than with lower prophylactic doses.

Dermatologic

Dermatologic side effects have included pruritus (2%). Cutaneous reactions ranging from rash, photosensitivity, and urticaria have been reported during postmarketing experience.

Gastrointestinal

Gastrointestinal side effects have included abdominal pain (5% to 17%), nausea (3% to 12%), vomiting (1% to 12%), diarrhea (4% to 8%), mouth ulcers (6%), anorexia (5%), dyspepsia (2%), and gastritis (2%). GI upset has also been reported. Stomatitis has been reported during postmarketing experience.

Hepatic

Hepatic side effects have included transient increases in liver function tests. These increases have not required discontinuation of therapy. Rare cases of hepatitis, cholestasis, and a single case of hepatic failure have been reported during postmarketing experience.

Musculoskeletal

Musculoskeletal side effects have included asthenia (8%), myalgia (7%), and back pain (4%).

Nervous system

Nervous system side effects have included headache (4% to 17%), dizziness (2% to 5%), vertigo (2%), and visual disturbances (2%). Rare cases of seizures and psychotic events (such as hallucinations) have been reported during postmarketing experience. However, a causal relationship has not been established.

Respiratory

Respiratory side effects have rarely included cough (4%).

Hypersensitivity

Hypersensitivity side effects have included rare cases of anaphylaxis. Rare cases of erythema multiforme, Stevens-Johnson syndrome, vasculitis, and angioedema have been reported during postmarketing experience.

Psychiatric

Psychiatric side effects including strange or vivid dreams (7%), insomnia (3%), anxiety (less than 1%), and depression (less than 1%) have been reported.

Hematologic

Hematologic side effects including neutropenia, anemia (rarely), and pancytopenia in patients with severe renal impairment treated with proguanil have been reported during the postmarketing experience.

Other

Other side effects have included flu-like symptoms (4%) and fever (3%).

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Malarone (www.drugs.com/malarone.html).