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Macrobid Prescription
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Generic Name: nitrofurantoin (NYE troe fue RAN toin)
Brand Names: Furadantin, Macrobid, Macrodantin, Nitro Macro
Macrobid (nitrofurantoin) is an antibiotic used to treat urinary tract infections. Includes side effects, interactions and indications. Average Savings for nitrofurantoin monohydrat (generic): 29.72%
Generic Name: nitrofurantoin (NYE troe fue RAN toin)
Brand Names: Furadantin, Macrobid, Macrodantin, Nitro Macro
Macrobid (nitrofurantoin) is an antibiotic used to treat urinary tract infections. Includes side effects, interactions and indications. Average Savings for nitrofurantoin monohydrat (generic): 29.72%
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30 tablets of Macrobid 40 mg
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Macrobid Drug Information:

Macrobid (Nitrofurantoin) is an antibiotic that fights bacteria in the body. Macrobid is used to treat urinary tract infections. Macrobid may also be used for purposes not listed in this medication guide. You should not take Macrobid if you have severe kidney disease, urination problems, or a history of jaundice or liver problems caused by Nitrofurantoin. Do not take Macrobid if you are in the last 2 to 4 weeks of pregnancy. You should not take Macrobid if you are allergic to Nitrofurantoin, or if you have: Learn more

Macrobid Side Effects

Note: This document contains side effect information about nitrofurantoin. Some of the dosage forms listed on this page may not apply to the brand name Macrobid.

For the Consumer

Applies to nitrofurantoin: oral capsule, oral suspension

Along with its needed effects, nitrofurantoin (the active ingredient contained in Macrobid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nitrofurantoin:

More common

  • Changes in facial skin color
  • chest pain
  • chills
  • cough
  • fever
  • general feeling of discomfort or illness
  • hives
  • hoarseness
  • itching
  • joint or muscle pain
  • shortness of breath
  • skin rash
  • sudden trouble in swallowing or breathing
  • swelling of the face, mouth, hands, or feet
  • troubled breathing

Less common

  • Black, tarry stools
  • blood in the urine or stools
  • burning, numbness, tingling, or painful sensations
  • dizziness
  • drowsiness
  • headache
  • pinpoint red spots on the skin
  • sore throat
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness in the arms, hands, legs, or feet


  • Abdominal or stomach pain
  • blindness
  • blistering, peeling, or loosening of the skin and mucous membranes
  • blue-yellow color blindness
  • bluish color of the fingernails, lips, skin, palms, or nail beds
  • blurred vision or loss of vision, with or without eye pain
  • bulging soft spot on the head of an infant
  • change in the ability to see colors, especially blue or yellow
  • confusion
  • cracks in the skin
  • darkening of the urine
  • decreased vision
  • diarrhea
  • diarrhea, watery and severe, which may also be bloody
  • eye pain
  • general tiredness and weakness
  • light-colored stools
  • loss of appetite
  • loss of heat from the body
  • mental depression
  • mood or mental changes
  • nausea or vomiting
  • pale skin
  • pale stools
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • red, thickened, or scaly skin
  • skin rash
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen or painful glands
  • tenderness of salivary glands
  • unpleasant breath odor
  • upper right abdominal pain
  • visual changes
  • vomiting of blood
  • wheezing or tightness in the chest
  • yellow eyes or skin

Some side effects of nitrofurantoin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • gas

Incidence not known

  • Dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • lack or loss of strength
  • loss of hair, temporary
  • sensation of spinning
  • uncontrolled eye movements

For Healthcare Professionals

Applies to nitrofurantoin: compounding powder, oral capsule, oral suspension


Frequency not reported: Chest pain, changes in EKG (e.g., nonspecific ST/T wave changes, bundle branch block) associated with pulmonary reactions, and vasculitis (sometimes associated with pulmonary reactions)


Rare (less than 0.01% to 0.1%): Exfoliative dermatitis, erythema multiforme (including Stevens-Johnson syndrome)

Frequency not reported: Transient alopecia, angioedema, maculopapular rash, erythematous rash, eczematous rash, pruritus, urticaria


Common (1% to 10%): Nausea, emesis, anorexia, flatulence

Uncommon (0.1% to 1%): Abdominal pain, diarrhea, dyspepsia, constipation

Rare (less than 0.1%): Parotitis, pseudomembranous colitis

Frequency not reported: Sialadenitis, pancreatitis


Frequency not reported: Dark colored urine


Rare (less than 0.1%): Cyanosis secondary to methemoglobinemia, aplastic anemia

Frequency not reported: Hemolytic anemia, leukopenia, agranulocytosis, granulocytopenia, megaloblastic anemia, eosinophilia, decreased hemoglobin, glucose-6-phosphate dehydrogenase deficiency anemia, thrombocytopenia


Rare (less than 0.1%): Hepatic reactions (including hepatitis, cholestatic jaundice, chronic active hepatitis, hepatic necrosis), hepatotoxicity with concurrent pulmonary reactions

Frequency not reported: Elevated AST (SGOT), elevated ALT (SGPT), elevated bilirubin, hepatic toxicity (presented with jaundice, abdominal pain, malaise, nausea, and anorexia)


Frequency not reported: Chronic, subacute, or acute pulmonary hypersensitivity reactions, lupus-like syndrome associated with pulmonary reactions, anaphylaxis


Frequency not reported: Increased serum phosphorus, increased alkaline phosphatase, increased lactate dehydrogenase, increased creatine phosphokinase

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Dizziness, drowsiness

Rare (less than 0.1%): Vertigo, benign intracranial hypertension (pseudotumor cerebri), bulging fontanels

Frequency not reported: Peripheral neuropathy, neuropathy (generally beginning as paresthesia of the lower extremities and the hands and progressing to muscle weakness and wasting), cerebellar dysfunction


Uncommon (0.1% to 1%): Amblyopia

Rare (less than 0.1%): Optic neuritis, retinopathy (due to intraretinal crystals)

Frequency not reported: Nystagmus, diplopia


Uncommon (0.1% to 1%): Fever, chills, malaise

Rare (0.01% to 0.1%): Bulging fontanels in infants

Frequency not reported: Asthenia, arthralgia, myalgia, drug fever


Frequency not reported: Psychotic reactions, confusion, depression


Rare (less than 0.1%): Acute interstitial nephritis


Uncommon (0.1% to 1%): Acute pulmonary hypersensitivity reaction

Rare (less than 0.1%): Cyanosis

Frequency not reported: Chronic, subacute, or acute pulmonary hypersensitivity reactions, cough, dyspnea, pulmonary infiltration with consolidation or pleural effusion on x-ray


Frequency not reported: Superinfections caused by resistant organisms (e.g., Pseudomonas species, Candida species)

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Macrobid (www.drugs.com/macrobid.html).