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Lupron (leuprolide) overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. Leuprolide reduces the amount of testosterone in men or estrogen in women.
Lupron is used in men to treat the symptoms of prostate cancer. Leuprolide only treats the symptoms of prostate cancer and does not treat the cancer itself.
Lupron Depot is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.
Lupron Depot-Ped is used to treat precocious (early-onset) puberty in both male and female children.
Lupron may also be used for purposes not listed in this medication guide.
Certain brands or strengths of leuprolide are used to treat only men and should not be used in women or children. Always check your medicine to make sure you have received the correct brand and strength. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.
Lupron can harm an unborn baby or cause birth defects. Do not use if you are pregnant or breastfeeding.Your symptoms may become temporarily worse when you first start using Lupron. Tell your doctor if this continues for longer than 2 months.
Call your doctor at once if you have a seizure, or unusual changes in mood or behavior.
You should not use Lupron if you are allergic to leuprolide or similar medicines such as buserelin, goserelin, histrelin, nafarelin, or if you have abnormal vaginal bleeding that has not been checked by a doctor.
Certain brands or strengths of leuprolide are used to treat only men and should not be used in women or children. Always check your medicine to make sure you have received the correct brand and strength.
Leuprolide can cause birth defects. Do not use if you are pregnant or breastfeeding. Tell your doctor right away if you become pregnant during treatment.
To make sure Lupron is safe for you, tell your doctor if you have ever had:
depression, mental illness or psychosis;
seizures or epilepsy;
a brain tumor or blood vessel disorder;
heart disease, congestive heart failure, long QT syndrome;
diabetes;
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
risk factors for bone loss (personal or family history of osteoporosis, smoking, alcohol use, taking steroid or seizure medicines long term).
Lupron usually causes women to stop ovulating or having menstrual periods. However, you may still be able to get pregnant. Use a barrier form of birth control (condom or diaphragm with spermicide). Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.
Call your doctor if your periods continue while you are being treated with Lupron.
It is not known whether leuprolide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Lupron.
Lupron Depot injection is injected into a muscle, every 1 to 6 months. You may be shown how to use Lupron injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes. Lupron Depot injection must be administered under the supervision of a physician.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Different brands or strengths of leuprolide are used to treat different conditions. It is very important that you receive exactly the brand and strength your doctor has prescribed. Always check your medication to make sure you have received the correct brand and type prescribed by your doctor.
Read and carefully follow any Instructions for Use provided with your medicine. Do not use Lupron if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.
Your symptoms may become temporarily worse as your hormones adjust to leuprolide. Keep using the medicine as directed, and tell your doctor if your condition is still worse after 2 months of using this medicine.
Leuprolide can have long lasting effects on your body. You may need frequent medical tests while using this medicine and for a short time after your last dose.
Store Lupron in the original carton at room temperature, away from moisture and heat. Protect from light.
Mixed Lupron Depot injection be used immediately (within 30 minutes) as it does not contain a preservative.
Call your doctor for instructions if you miss a dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Leuprolide can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Get emergency medical help if you have signs of an allergic reaction to Lupron: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor at once if you have:
bone pain, loss of movement in any part of your body;
swelling, rapid weight gain;
a seizure;
unusual changes in mood or behavior (crying spells, anger, feeling irritable);
sudden chest pain or discomfort, wheezing, dry cough or hack;
painful or difficult urination; or
high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor.
Rare but serious side effects may occur. Call your doctor if you have:
pain or unusual sensations in your back, numbness, weakness, or tingly feeling in your legs or feet;
muscle weakness or loss of use, loss of bowel or bladder control;
heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech.
Common Lupron side effects may include:
hot flashes, sweating, acne, rash, itching, scaly skin;
mood changes;
headache, general pain;
vaginal swelling, itching, or discharge;
breakthrough bleeding;
weight gain;
decreased testicle size; or
redness, pain, swelling, or oozing where the shot was given.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Leuprolide can cause a serious heart problem, especially if you use certain medicines at the same time, such as antibiotics, antifungal medicine, antidepressants, anti-malaria medicine, asthma inhalers, antipsychotic medicine, cancer medicine, certain HIV/AIDS medicine, heart or blood pressure medicine, or medicine to prevent vomiting. Tell your doctor about all your current medicines and any medicine you start or stop using.
Other drugs may interact with leuprolide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lupron only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Lupron Depot (3-month) (www.drugs.com/lupron.html).
Note: This document contains side effect information about leuprolide. Some of the dosage forms listed on this page may not apply to the brand name Lupron.
Applies to leuprolide: powder for suspension 1 month, powder for suspension 3 month, powder for suspension 4 month, powder for suspension 6 month, solution
Along with its needed effects, leuprolide (the active ingredient contained in Lupron) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking leuprolide:
For adults
Less common
Rare
For males only (adults)
More common
Rare
Incidence not known
For females only (adults)
Rare
For children
Rare
For females only (children)—expected in first few weeks
Rare
Some side effects of leuprolide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For adults
More common
Less common
For females only (adults)
More common
Less common
For males only (adults)
More common
Less common
Applies to leuprolide: intramuscular kit, intramuscular powder for injection, intramuscular powder for injection extended release, subcutaneous implant, subcutaneous kit, subcutaneous powder for injection extended release, subcutaneous solution
The most commonly reported side effects were general pain, peripheral edema, hot flashes, hair loss, ECG changes, ischemia.
Postmarketing reports: Anaphylactoid reactions
Very common (10% or more): Vaginal dryness (37%), breast tenderness (up to 14%)
Common (1% to 10%): Urinary frequency/urgency, hematuria, urinary tract infection, ovarian hyperstimulation, testicular soreness/pain, breast soreness/tenderness, testicular atrophy, erectile dysfunction, penile disorder, reduced penis size, vaginal hemorrhage, gynecomastia, breast changes, breast enlargement, decrease in testicular size, impotence
Very common (10% or more): ECG changes (19%), ischemia (19%)
Common (1% to 10%): Hypertension, murmur, phlebitis, thrombosis, arrhythmias, angina, myocardial infarction
Very common (10% or more): Hot flashes (up to 91%)
Very rare (less than 0.01%): Pituitary apoplexy
Frequency not reported: Transient increase in serum testosterone concentrations during the first 2 days of therapy, 'flare' phenomenon
Common (1% to 10%): Depression, insomnia/sleep disorder, anxiety, nervousness, decreased libido, increased libido
Common (1% to 10%): Dizziness/lightheadedness, headache
Common (1% to 10%): Constipation, nausea/vomiting, flatulence, dyspepsia, gastroenteritis/colitis, diarrhea, dysphagia, gastrointestinal bleeding, gastrointestinal disturbance, peptic ulcer, rectal polyps
Very common (10% or more): Hair loss (up to 18%)
Common (1% to 10%): Skin rash, acne, itching, dry skin, ecchymosis, pruritus, photosensitivity, clamminess, night sweats, increased sweating, skin pigmentation
Common (1% to 10%): Bone/joint pain, myalgia, ankylosing spondylosis, arthritis, blurred disc margins, bone fracture, muscle stiffness, muscle tenderness, pelvic fibrosis, spasms/cramps
Frequency not reported: Backache, muscle atrophy, limb pain
Postmarketing reports: : Spinal fracture/paralysis, tenosynovitis-like symptoms
Common (1% to 10%): Anemia
Postmarketing reports: Decreased WBC
Frequency not reported: Decreased red blood cell count/hematocrit/hemoglobin
Common (1% to 10%): Dyspnea, sinus congestion, chest tightness, decreased breathing sounds, hemoptysis, pleuritic chest pain, pulmonary infiltrate, rales/rhonchi, rhinitis, strep throat, wheezing/bronchitis, pulmonary edema, pulmonary embolism
Frequency not reported: Erythema, ecchymosis, induration, abscess, pain, swelling, nodules, ulcers, irritation, necrosis at the site of injection
Very common (10% or more): General pain (up to 32.7%), peripheral edema (12.5%), asthenia (10%)
Common (1% to 10%): Tinnitus
Frequency not reported: Disturbance of smell/taste, vertigo
Postmarketing reports: Hearing disorder
Frequency not reported: Hepatitis, hepatomegaly
Postmarketing reports: Hepatic dysfunction
Common (1% to 10%): Anorexia
Frequency not reported: Weight gain/loss
Postmarketing reports: Diabetes
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Lupron Depot (3-month) (www.drugs.com/lupron.html).
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