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Note: This document contains side effect information about leuprolide. Some of the dosage forms listed on this page may not apply to the brand name Lupron.
For the ConsumerApplies to leuprolide: powder for suspension 1 month, powder for suspension 3 month, powder for suspension 4 month, powder for suspension 6 month, solution
Along with its needed effects, leuprolide (the active ingredient contained in Lupron) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking leuprolide:
For adults
Less common
Rare
For males only (adults)
More common
Rare
Incidence not known
For females only (adults)
Rare
For children
Rare
For females only (children)—expected in first few weeks
Rare
Some side effects of leuprolide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For adults
More common
Less common
For females only (adults)
More common
Less common
For males only (adults)
More common
Less common
For Healthcare Professionals
Applies to leuprolide: intramuscular kit, intramuscular powder for injection, intramuscular powder for injection extended release, subcutaneous implant, subcutaneous kit, subcutaneous powder for injection extended release, subcutaneous solution
GeneralThe most commonly reported side effects were general pain, peripheral edema, hot flashes, hair loss, ECG changes, ischemia.
HypersensitivityPostmarketing reports: Anaphylactoid reactions
GenitourinaryVery common (10% or more): Vaginal dryness (37%), breast tenderness (up to 14%)
Common (1% to 10%): Urinary frequency/urgency, hematuria, urinary tract infection, ovarian hyperstimulation, testicular soreness/pain, breast soreness/tenderness, testicular atrophy, erectile dysfunction, penile disorder, reduced penis size, vaginal hemorrhage, gynecomastia, breast changes, breast enlargement, decrease in testicular size, impotence
CardiovascularVery common (10% or more): ECG changes (19%), ischemia (19%)
Common (1% to 10%): Hypertension, murmur, phlebitis, thrombosis, arrhythmias, angina, myocardial infarction
EndocrineVery common (10% or more): Hot flashes (up to 91%)
Very rare (less than 0.01%): Pituitary apoplexy
Frequency not reported: Transient increase in serum testosterone concentrations during the first 2 days of therapy, 'flare' phenomenon
PsychiatricCommon (1% to 10%): Depression, insomnia/sleep disorder, anxiety, nervousness, decreased libido, increased libido
Nervous systemCommon (1% to 10%): Dizziness/lightheadedness, headache
GastrointestinalCommon (1% to 10%): Constipation, nausea/vomiting, flatulence, dyspepsia, gastroenteritis/colitis, diarrhea, dysphagia, gastrointestinal bleeding, gastrointestinal disturbance, peptic ulcer, rectal polyps
DermatologicVery common (10% or more): Hair loss (up to 18%)
Common (1% to 10%): Skin rash, acne, itching, dry skin, ecchymosis, pruritus, photosensitivity, clamminess, night sweats, increased sweating, skin pigmentation
MusculoskeletalCommon (1% to 10%): Bone/joint pain, myalgia, ankylosing spondylosis, arthritis, blurred disc margins, bone fracture, muscle stiffness, muscle tenderness, pelvic fibrosis, spasms/cramps
Frequency not reported: Backache, muscle atrophy, limb pain
Postmarketing reports: : Spinal fracture/paralysis, tenosynovitis-like symptoms
HematologicCommon (1% to 10%): Anemia
Postmarketing reports: Decreased WBC
Frequency not reported: Decreased red blood cell count/hematocrit/hemoglobin
RespiratoryCommon (1% to 10%): Dyspnea, sinus congestion, chest tightness, decreased breathing sounds, hemoptysis, pleuritic chest pain, pulmonary infiltrate, rales/rhonchi, rhinitis, strep throat, wheezing/bronchitis, pulmonary edema, pulmonary embolism
LocalFrequency not reported: Erythema, ecchymosis, induration, abscess, pain, swelling, nodules, ulcers, irritation, necrosis at the site of injection
OtherVery common (10% or more): General pain (up to 32.7%), peripheral edema (12.5%), asthenia (10%)
Common (1% to 10%): Tinnitus
Frequency not reported: Disturbance of smell/taste, vertigo
Postmarketing reports: Hearing disorder
HepaticFrequency not reported: Hepatitis, hepatomegaly
Postmarketing reports: Hepatic dysfunction
MetabolicCommon (1% to 10%): Anorexia
Frequency not reported: Weight gain/loss
Postmarketing reports: Diabetes
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Lupron Depot (3-month) (www.drugs.com/lupron.html).
August 4, 2022
August 4, 2022
August 4, 2022
July 26, 2022
July 26, 2022
July 22, 2022