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Lovenox

Lovenox Prescription
Generic Name: enoxaparin (ee NOX a PAR rin)
Brand Names: Lovenox
Lovenox is used to prevent deep vein thrombosis (DVT) which can lead to blood clots in the lungs. Learn about side effects, interactions and indications.

Average Savings for enoxaparin sodium (generic): 42.4%
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Lovenox Drug Information:

Lovenox (enoxaparin) is an anticoagulant that helps prevent the formation of blood clots. Lovenox is used to treat or prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery, or in people who are bed-ridden due to a prolonged illness. Lovenox is also used to prevent blood vessel complications in people with certain types of angina (chest pain) or heart attack. You should not use Lovenox if you have active bleeding, or a low level of platelets in your blood after testing positive for a certain antibody while using enoxaparin. Learn more

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Lovenox Side Effects

Note: This document contains side effect information about enoxaparin. Some of the dosage forms listed on this page may not apply to the brand name Lovenox.

In Summary

Common side effects of Lovenox include: anemia and hemorrhage. Other side effects include: fever. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to enoxaparin: solution

Warning

Injection route (Solution)

Epidural or spinal hematomas, which may result in long-term or permanent paralysis, may occur in patients who are anticoagulated with low molecular weight heparins or heparinoids and are receiving neuraxial anesthesia or undergoing spinal puncture. Factors that can increase the risk of developing these hematomas include: use of indwelling epidural catheters, concomitant use of drugs affecting hemostasis such as NSAIDs, platelet inhibitors, or other anticoagulants, or history of traumatic or repeated epidural or spinal puncture, spinal deformity, or spinal surgery. Optimal timing between the administration of enoxaparin sodium and neuraxial procedures is not known. Monitor patients frequently for neurological impairment. If neurological compromise is noted, urgent treatment is necessary. Consider risks/benefits before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis.

Along with its needed effects, enoxaparin (the active ingredient contained in Lovenox) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enoxaparin:

More common

  • Bleeding gums
  • coughing up blood
  • difficulty with breathing or swallowing
  • dizziness
  • headache
  • increased menstrual flow or vaginal bleeding
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • shortness of breath

Less common

  • Bruising
  • chest discomfort
  • collection of blood under the skin
  • confusion
  • continuing bleeding or oozing from the nose and/or mouth, or surgical wound
  • convulsions (seizures)
  • fever
  • irritability
  • lightheadedness
  • lower back pain
  • pain or burning while urinating
  • swelling of the hands or feet
  • tightness in the chest
  • uncontrolled bleeding at the site of injection
  • vomiting of blood or material that looks like coffee grounds
  • wheezing

Rare

  • Back pain
  • burning, pricking, tickling, or tingling sensation
  • chest pain
  • chills
  • cough
  • decreased urine output
  • dilated neck veins
  • dizziness or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • fast or irregular heartbeat
  • general feeling of discomfort or illness
  • irregular breathing
  • leg weakness
  • problems with bowel or bladder function
  • skin rash or hives
  • sneezing
  • sore throat
  • sudden fainting
  • swelling of the face, fingers, feet, genitals, mouth, or tongue
  • thickening of the bronchial secretions
  • troubled breathing
  • weight gain

Incidence not known

  • Abdominal or stomach pain
  • deep, dark purple bruise
  • hives or welts
  • irregular heartbeat
  • itching, pain, redness, or swelling
  • large, flat, blue, or purplish patches in the skin
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • skin rash
  • unusual tiredness or weakness
  • weakness or heaviness of the legs

Some side effects of enoxaparin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Diarrhea
  • irritation, pain, or redness at the place of injection

For Healthcare Professionals

Applies to enoxaparin: injectable solution

General

The most common adverse reactions were bleeding, anemia, thrombocytopenia, elevation of serum aminotransferase, diarrhea, and nausea.

Cardiovascular

Common (1% to 10%): Major hemorrhage

Uncommon (0.1% to 1%): Atrial fibrillation, heart failure

Frequency not reported: Hemorrhage

Postmarketing reports: Shock, valve thrombosis in patients with prosthetic heart valves

Hematologic

Common (1% to 10%): Thrombocytopenia, anemia, platelet counts between 100,000 and 50,000/mm3

Uncommon (0.1% to 1%): Platelet counts less than 50,000/mm3

Frequency not reported: Thrombocytosis

Postmarketing reports: Hemorrhagic anemia, platelet count increased, eosinophilia

Hepatic

Common (1% to 10%): ALT increased asymptomatically, AST increased asymptomatically

Frequency not reported: Hepatic enzymes increased

Postmarketing reports: Hepatocellular liver injury, cholestatic liver injury

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea

Uncommon (0.1% to 1%): Retroperitoneal hemorrhage

Local

Common (1% to 10%): Injection site hematoma, injection site pain, other injection site reaction

Uncommon (0.1% to 1%): Local irritation, injection site skin necrosis

Postmarketing reports: Injection site nodules

Dermatologic

Common (1% to 10%): Urticaria, pruritus, erythema

Uncommon (0.1% to 1%): Bullous dermatitis

Postmarketing reports: Cutaneous vasculitis, skin necrosis, alopecia

Metabolic

Common (1% to 10%): Peripheral edema, edema

Rare (less than 0.1%): Hyperkalemia

Postmarketing reports: Hyperlipidemia, hypertriglyceridemia

Immunologic

Common (1% to 10%): Allergic reaction

Rare (0.01% to 0.1%): Anaphylactic/anaphylactoid reaction

Very rare (less than 0.01%): Immuno-allergic thrombocytopenia

Postmarketing reports: Immuno-allergic thrombocytopenia with thrombosis

Respiratory

Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Lung edema, pneumonia

Genitourinary

Uncommon (0.1% to 1%): Hematuria

Psychiatric

Common (1% to 10%): Confusion

Other

Common (1% to 10%): Fever

Nervous system

Uncommon (0.1% to 1%): Intracranial hemorrhage

Postmarketing reports: Headache, spinal hematoma

Musculoskeletal

Postmarketing reports: Osteoporosis following treatment longer than 3 months

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Lovenox (www.drugs.com/lovenox.html).