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Lotronex

Generic Name: alosetron (oral) (a LO ze tron)
Brand Names: Lotronex
Lotronex is used to treat severe, chronic irritable bowel syndrome (IBS) in women. Learn about side effects, interactions and indications.
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Drug Information:
Lotronex (alosetron) blocks the action of a chemical called serotonin in the intestines. This slows the movement of stools (bowel movements) through the intestines. Lotronex is used to treat severe, chronic irritable bowel syndrome (IBS) in women with diarrhea as the main symptom for at least 6 months. Alosetron should be used only by women who have tried other IBS treatments without success. Alosetron not been shown to be effective in men with IBS. Lotronex is not a cure for irritable bowel syndrome. After you stop taking this medicine, your symptoms may return within 1 week. Learn more

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Lotronex Side Effects

Note: This document contains side effect information about alosetron. Some of the dosage forms listed on this page may not apply to the brand name Lotronex.

In Summary

Common side effects of Lotronex include: constipation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to alosetron: oral tablet

Warning

Oral route (Tablet)

Infrequent but serious gastrointestinal adverse reactions have been reported with alosetron hydrochloride, including ischemic colitis and serious complications of constipation, that resulted in hospitalization, blood transfusion, surgery, and death. Alosetron hydrochloride is indicated only for women with severe diarrhea-predominant irritable bowel syndrome (IBS) who have not responded adequately to conventional therapy. Immediately discontinue alosetron hydrochloride in patients who develop constipation or symptoms of ischemic colitis. Do not resume in patients who develop ischemic colitis. If constipation resolves, resume alosetron hydrochloride only on the advice of treating prescriber.

Along with its needed effects, alosetron (the active ingredient contained in Lotronex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alosetron:

More common

  • Constipation

Rare

  • Bloody diarrhea
  • new or worsening stomach pain or discomfort
  • rectal bleeding

Incidence not known

  • Abdominal or stomach pain, cramping, or burning
  • black, tarry stools
  • diarrhea
  • fever
  • heartburn
  • indigestion
  • nausea
  • vomiting with or without blood or material that looks like coffee grounds

Get emergency help immediately if any of the following symptoms of overdose occur while taking alosetron:

Symptoms of overdose

  • Clumsiness, unsteadiness, trembling, or other problems with muscle control or coordination
  • convulsions (seizures)
  • difficulty breathing
  • shakiness and unsteady walk
  • withdrawn or socially detached behavior

Some side effects of alosetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Bleeding after bowel movement
  • full or bloated feeling
  • pressure in the stomach
  • swelling of abdominal or stomach area
  • uncomfortable swelling around rectal area

Incidence not known

  • Headache
  • skin rash

For Healthcare Professionals

Applies to alosetron: oral tablet

General

The most commonly reported side effects included constipation, abdominal discomfort/pain, diarrhea, and nausea.

Gastrointestinal

Very common (10% or more): Constipation (up to 75%)

Common (1% to 10%): Abdominal discomfort, abdominal distention, abdominal pain, abdominal pain upper, diarrhea, flatulence, gastrointestinal discomfort, gastrointestinal pain, hemorrhoid hemorrhage, hemorrhoids, nausea, reflux, regurgitation, viral gastroenteritis, vomiting

Uncommon (0.1% to 1%): Dyspeptic symptoms, gastrointestinal lesions, gastrointestinal spasms, hyposalivation, ischemic colitis

Rare (0.01% to 0.1%): Abnormal tenderness, colitis, decreased gastric motility, diverticulitis, gastritis, gastroduodenitis, gastroenteritis, gastrointestinal intussusception, gastrointestinal obstruction, gastrointestinal signs/symptoms, hyperacidity, ileus, oral symptoms, positive fecal occult blood, proctitis, ulcerative colitis

Frequency not reported: Complications of colitis

Postmarketing reports: Impaction, perforation, small bowel mesenteric ischemia, ulceration

Respiratory

Common (1% to 10%): Cough, nasopharyngitis, sinusitis, upper respiratory tract infection

Uncommon (0.1% to 1%): Breathing disorders

Rare (0.01% to 0.1%): Laryngitis, nose infection, throat infection, viral nose infection, viral throat infection

Genitourinary

Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Urinary frequency

Rare (0.01% to 0.1%): Bladder inflammation, diuresis, female reproductive tract bleeding/hemorrhage, polyuria, sexual function disorders, urinary tract hemorrhage

Hepatic

Common (1% to 10%): ALT elevation

Rare (0.01% to 0.1%): Abnormal bilirubin levels, cholecystitis

Frequency not reported: Elevated alkaline phosphatase, elevated AST, elevated bilirubin, hepatitis without jaundice

Other

Uncommon (0.1% to 1%): Fatigue, malaise, pain, temperature regulation disturbances

Rare (0.01% to 0.1%): Cold sensation, ear infections, hot and cold sensations, viral ear infections

Dermatologic

Uncommon (0.1% to 1%): Sweating, urticaria

Rare (0.01% to 0.1%): Acne, allergic skin reaction, alopecia, dermatitis, dermatosis, eczema, folliculitis, hair loss, nail disorders, sebum disorders, skin infections, sweat disorders

Postmarketing reports: Rash

Nervous system

Uncommon (0.1% to 1%): Hypnagogic effects

Rare (0.01% to 0.1%): Burning sensations, cognitive function disorder, equilibrium disorders, hypoesthesia, memory effects, sedation, taste disturbance, tremors

Frequency not reported: Headache

Musculoskeletal

Uncommon (0.1% to 1%): Cramps

Rare (0.01% to 0.1%): Bone pain, muscle pain, muscle stiffness, rigidity, skeletal pain, tightness

Frequency not reported: Muscle spasms

Cardiovascular

Uncommon (0.1% to 1%): Tachyarrhythmias

Rare (0.01% to 0.1%): Arrhythmias, contusions, extrasystoles, hematoma, hemorrhage, increased blood pressure

Psychiatric

Uncommon (0.1% to 1%): Anxiety

Rare (0.01% to 0.1%): Confusion, depressive moods, dreams

Metabolic

Rare (0.01% to 0.1%): Disorder of calcium metabolism, disorder of phosphate metabolism, fluid disturbances, hyperglycemia, hypofunction

Immunologic

Rare (0.01% to 0.1%): Fungal infections, fungal reproductive infections, reproductive infections

Hematologic

Rare (0.01% to 0.1%): Quantitative hemoglobin defects, quantitative red cell defects

Ocular

Rare (0.01% to 0.1%): Light sensitivity of eyes

Endocrine

Rare (0.01% to 0.1%): Hypothalamus/pituitary hypofunction

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Lotronex (www.drugs.com/lotronex.html).